A5070805074- Diatoms and Algae Research
- Advanced biosensing and bioanalysis techniques
- Supramolecular Self-Assembly in Materials
- Gold and Silver Nanoparticles Synthesis and Applications
- Quantum Dots Synthesis And Properties
- Molecular Junctions and Nanostructures
- Nanocluster Synthesis and Applications
- Graphene and Nanomaterials Applications
- Biosensors and Analytical Detection
- Calcium Carbonate Crystallization and Inhibition
- Graphene research and applications
- Polymer Surface Interaction Studies
- Advanced Chemical Sensor Technologies
- Force Microscopy Techniques and Applications
- Chemical Synthesis and Analysis
- Copper-based nanomaterials and applications
- Bacteriophages and microbial interactions
- Analytical Chemistry and Sensors
- Mass Spectrometry Techniques and Applications
- Advanced Nanomaterials in Catalysis
- Silk-based biomaterials and applications
- Advanced Photocatalysis Techniques
- Marine Biology and Environmental Chemistry
- Energetic Materials and Combustion
- Biochemical and Structural Characterization
United States Air Force Research Laboratory
2009-2024
Wright-Patterson Air Force Base
2012-2024
UES (United States)
2019-2020
Georgia Institute of Technology
2008-2010
Rice University
2007
Vanderbilt University
2001-2006
University of Pittsburgh
2000-2004
Our calculations show that a nonchiral nanocrystal is able to dramatically change the circular dichroism (CD) of chiral molecule when and form complex couple via dipole multipole Coulomb interactions. Plasmon resonances metal nanocrystals in nanocrystal−molecule result both resonant enhancement CD signals molecules appearance new spectral structures. Two mechanisms, which can influence effect, have been identified. The first mechanism plasmon-induced electromagnetic field inside molecule....
Nature is remarkable at tailoring the chirality of different biomolecules to suit specific functions. Chiral molecules can impart optical activity achiral materials in form particle's electronic transition frequency. Herein, we used peptides differing secondary structures (random coil and α-helix) artificially create optically active chiral gold nanoparticles through peptide-nanoparticle interactions as observed by circular dichroism (CD) spectroscopy. This interaction produces a CD signal...
The paper reviews recent progress on chiral nanocrystal assemblies with induced optical chirality and related circular dichroism. Many natural molecules biomolecules are exhibit remarkably strong (circular dichroism) due to their amazingly uniform atomic composition in a large ensemble. It is challenging realize artificial nanoscale systems since the structure of nanostructures may not be always controlled or even known. Nevertheless, has been accomplished it main scope this review. In...
A simple, one-pot process for synthesizing monodisperse gold nanoparticles in aqueous solution using multifunctional peptides is reported (see Figure). The peptide contains a synthesizing/binding domain and biomolecular recognition domain. binding reduces choloroaurate ions coats the while can be recognized by specific antibodies. Supporting information this article available on WWW under http://www.wiley-vch.de/contents/jc_2421/2005/z500172_s.pdf or from author. Please note: publisher not...
Viruses present a confined environment and unique protein surface topology (i.e. polarity, residue charge, relief) for nanoparticle synthesis are amenable to molecular biology manipulations. Consequently, we have examined the cowpea chlorotic mottle viruses of unmodified SubE (yeast), (HRE)-SubE engineered with interior HRE peptide epitopes (AHHAHHAAD), wild-type as viral templates potentiated reduction symmetry directed gold nanoparticles. In first approach, capsid actively AuCl4− by...
Peptides identified from combinatorial peptide libraries have been shown to bind a variety of abiotic surfaces. Biotic-abiotic interactions can be exploited create hybrid materials with interesting electronic, optical, or catalytic properties. Here we show that peptides phage display library assemble preferentially the edge planar surface graphene and affect electronic properties graphene. Molecular dynamics simulations experiments provide insight into mechanism binding edge.
We report a plasmonic paper-based analytical platform with functional versatility and subattomolar (<10–18 M) detection limit using surface-enhanced Raman scattering as transduction method. The microfluidic device (μPAD) is made lithography-free process by simple cut drop Complex samples are separated surface chemical gradient created differential polyelectrolyte coating of the paper. μPAD starlike shape designed to enable liquid handling lateral flow without microchannel patterning. This...
Peptide-enabled synthesis of inorganic nanostructures represents an avenue to access catalytic materials with tunable and optimized properties. This is achieved via peptide complexity programmability that missing in traditional ligands for nanomaterials. Unfortunately, there limited information available correlate sequence particle structure activity date. As such, the application peptide-enabled nanocatalysts remains trial error approaches. In this paper, a hybrid experimental computational...
Catalytic bimetallic nanoparticles are synthesized by exploiting the interaction between peptides and inorganic materials to program peptide sequence such that it can serve as a template in synthesis of gold well direct binding Pd ions surface Au (see figure).
The design of active nanostructures whose form and properties can be modulated by remote means is an important challenge in nanoscience. Here we report two types nanoparticle complexes, with controlled near-infrared illumination, resulting from the assembly photothermally responsive plasmonic nanoparticles thermally labile biomolecular linkers. Au nanoshells (NS) quantum dots (QD) are assembled using coiled-coil peptides into NS−NS NS−QD complexes. Illumination complexes results reversible...
Abstract Self‐assembly and function of biologically modified metal nanostructures depend on surface‐selective adsorption; however, the influence shape surfaces peptide adsorption mechanisms has been poorly understood. The single molecules in aqueous solution (Tyr 12 , Ser A3, Flg‐Na 3 ) is investigated even {111} surfaces, stepped a 2 nm cuboctahedral nanoparticle gold using molecular dynamics simulation with CHARMM‐METAL force field. Strong selective found inner edges (–20 to –60 kcal/mol...
The ability to control the size, shape, composition, and activity of nanomaterials presents a formidable challenge. Peptide approaches represent new avenues achieve such at synthetic level; however, critical interactions bio/nano interface that direct precision remain poorly understood. Here we present evidence suggest materials-directing peptides bind specific time points during Pd nanoparticle (NP) growth, dictated by material crystallinity. As surfaces are presented, rapid peptide binding...
Monte Carlo simulations are performed to study adsorption and desorption of coarse-grained peptide chains on generic gold palladium surfaces in the presence solvent. The atomistic structural details ignored within amino acid residues; however, their specificity hydrophobicity incorporated via an interaction matrix guided by simulation. Adsorption probabilities peptides A3, Flg, Pd2, Pd4, Gly10, Pro10 studied analysis mobility each residue, energy with surface, profiles proximity radius...
Peptide-based methods represent new approaches to selectively produce nanostructures with potentially important functionality. Unfortunately, biocombinatorial can only select peptides target affinity and not for the properties of final material. In this work, we present evidence demonstrate that materials-directing be controllably modified substantially enhance particle functionality without significantly altering nanostructural morphology. To end, modification selected residues vary...
The ability to tune the size, shape, and composition of nanomaterials at length scales <10 nm remains a challenging task. Such capabilities are required fully realize application nanotechnology for catalysis, energy storage, biomedical technologies. Conversely, nature employs biomacromolecules such as proteins peptides highly specific nanoparticle ligands that demonstrate exacting precision over particle morphology through controlling biotic/abiotic interface. Here we finely surface...
The performance of aluminum nanomaterial based energetic formulations is dependent on the mass transport, diffusion distance, and stability reactive components. Here we use a biologically inspired approach to direct assembly oxidizer loaded protein cages onto surface nanoparticles improve reaction kinetics by reducing distance between reactants. Ferritin were with ammonium perchlorate (AP) or iron oxide assembled nAl create an oxidation-reduction first demonstration nanoscale biobased...
Sensors for human health and performance monitoring require biological recognition elements (BREs) at device interfaces the detection of key molecular biomarkers that are measurable state indicators. BREs, including peptides, antibodies, nucleic acids, bind to in vicinity sensor surface create a signal proportional biomarker concentration. The discovery BREs with required sensitivity selectivity low concentrations remains fundamental challenge. In this study, we describe an in-silico...
Nanoparticles (NPs) can be conjugated with diverse biomolecules and employed in biosensing to detect target analytes biological samples. This proven concept was primarily used during the COVID-19 pandemic gold-NP-based lateral flow assays (LFAs). Considering gold price its worldwide depletion, here we show that novel plasmonic NPs based on inexpensive metals, titanium nitride (TiN) copper covered a shell (Cu@Au), perform comparable or even better than nanoparticles. After conjugation, these...
Liquid-phase exfoliation using biomolecules in aqueous solution is a promising approach to obtain high quality 2D nanosheets. For example, the well-studied graphene-binding peptide, P1 (sequence HSSYWYAFNNKT), has been previously investigated and shown have good ability exfoliate graphene sheets conditions under sonication, maintaining colloidal stability. Building on this, biomolecular exfoliant assembly motif (BEAM) that features domain at one end hexagonal boron nitride (h-BN) binding...
A recombinant protein, silaffin rSilC, adsorbed on a tailored polyelectrolyte surface is capable of initiating the nucleation and growth 4 nm titania nanoparticles in dispersed manner under ambient conditions. The approach presented here may be readily applicable to other organic inorganic materials enable robust synthesis uniform organic–inorganic nanostructures with controllable dimensions distributions.
In this Article, we report the unusual behavior of two peptides (Ti-1 (QPYLFATDSLIK) and Ti-2 (GHTHYHAVRTQT)) with high affinity for titania that efficiently promote mineralization from an aqueous titanium bisammonium lactatodihydroxide (TiBALDH) solution, yielding small (ca. 4 nm) nanoparticles. As a result, were able to produce first time using biomimetic approach highly stable sub-10-nm sols. Both sequences show activity per unit peptide concentration capacity control particle size...