A5065548271- Virus-based gene therapy research
- Immune cells in cancer
- CRISPR and Genetic Engineering
- CAR-T cell therapy research
- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Xenotransplantation and immune response
- Glioma Diagnosis and Treatment
- Renal Diseases and Glomerulopathies
- Single-cell and spatial transcriptomics
- Lymphatic System and Diseases
- Herpesvirus Infections and Treatments
- Kruppel-like factors research
- Intracerebral and Subarachnoid Hemorrhage Research
- Immune Cell Function and Interaction
- Genetic Syndromes and Imprinting
- Neuroinflammation and Neurodegeneration Mechanisms
- COVID-19 and healthcare impacts
- Cannabis and Cannabinoid Research
- Systemic Sclerosis and Related Diseases
- Brain Metastases and Treatment
- Neonatal Health and Biochemistry
- Adenosine and Purinergic Signaling
- Heme Oxygenase-1 and Carbon Monoxide
- Phagocytosis and Immune Regulation
University of Alabama
2025
University of Alabama at Birmingham
2021-2024
Pediatric Nephrology of Alabama
2021-2022
The kidney contains a population of resident macrophages from birth that expands as it grows and forms contiguous network throughout the tissue. Kidney-resident (KRMs) are important in homeostasis response to acute injury. While many microenvironments, is unknown whether KRMs heterogeneous differentiated by function location. We combined single-cell RNA-Seq (scRNA-Seq), spatial transcriptomics, flow cytometry, immunofluorescence imaging localize, characterize, validate KRM populations during...
Abstract Pig-to-human xenotransplantation is rapidly approaching the clinical arena; however, it unclear which immunomodulatory regimens will effectively control human immune responses to pig xenografts. Here, we transplant a gene-edited kidney into brain-dead recipient on pharmacologic immunosuppression and study response xenograft using spatial transcriptomics single-cell RNA sequencing. Human cells are uncommon in porcine cortex early after consist of primarily myeloid cells. Both...
AKI is a common sequela of infection with SARS-CoV-2 and contributes to the severity mortality from COVID-19. Here, we tested hypothesis that kidney alterations induced by COVID-19-associated could be detected in cells collected urine.
Abstract Pig-to-human xenotransplantation is rapidly approaching the clinical arena; however, it unclear which immunomodulatory regimens will effectively control human immune responses to pig xenografts. We transplanted a gene-edited kidney into brain-dead recipient on pharmacologic immunosuppression and studied response xenograft using spatial transcriptomics single-cell RNA sequencing. Human cells were uncommon in porcine cortex early after consisted of primarily myeloid cells. Both...
Acute kidney injury (AKI) is a major public health concern with significant morbidity and mortality no current treatments beyond supportive care dialysis. Preclinical studies have suggested that heme-oxygenase-1 (HO-1), an enzyme catalyzes the breakdown of heme, has promise as potential therapeutic target for AKI. Clinical trials involving HO-1 products (biliverdin, carbon monoxide, iron), however, not progressed Phase ½ level. We identified small-molecule inducers enable us to exploit full...
The long-term effects of a single episode acute kidney injury (AKI) induced by bilateral ischemia-reperfusion (BIRI) on lymphatic dynamics are not known. purpose this study was to determine if alterations in lymphatics sustained the long term and how they relate inflammation injury. Mice underwent BIRI as model AKI were followed up 9 mo. Although function markers normalized following initial injury, histological analysis revealed tissue damage for Transcriptional showed both late-stage...
Cheung, Matthew D.; Erman, Elise; Moore, Kyle H.; Ghajar-Rahimi, Gelare; Agarwal, Anupam; George, James F. Author Information
Abstract Leptomeningeal metastatic disease (LMD) occurs in 30–50% of newly diagnosed and recurrent pediatric malignant cerebellar tumors 20–45% supratentorial tumors. Radiation chemotherapy often cause substantial long-term neurotoxicity outcomes remain poor for patients with LMD. At recurrence, LMD is generally minimally responsive to conventional therapies. Immunovirotherapy engineered oncolytic HSV-1 G207 has emerged as a promising treatment children high-grade brain infects kills tumor...