Gavin Baker
A5062277456- Organ Donation and Transplantation
- Xenotransplantation and immune response
- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Dialysis and Renal Disease Management
- Trauma and Emergency Care Studies
- CRISPR and Genetic Engineering
- Virus-based gene therapy research
- Renal and Vascular Pathologies
- Tissue Engineering and Regenerative Medicine
- Nursing Roles and Practices
- Biomedical Ethics and Regulation
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer Genomics and Diagnostics
- Clinical practice guidelines implementation
- Hip and Femur Fractures
University of Alabama at Birmingham
2019-2024
University of Alabama
2024
Miami Transplant Institute
2022
A radical solution is needed for the organ supply crisis, and domestic pig a promising source. In preparation clinical trial of xenotransplantation, we developed an in vivo pre-clinical human model to test safety feasibility tenets established animal models. After performance novel, prospective compatible crossmatch, performed bilateral native nephrectomies brain-dead decedent subsequently transplanted two kidneys from genetically engineered xenotransplantation. The was hemodynamically...
Abstract Pig-to-human xenotransplantation is rapidly approaching the clinical arena; however, it unclear which immunomodulatory regimens will effectively control human immune responses to pig xenografts. Here, we transplant a gene-edited kidney into brain-dead recipient on pharmacologic immunosuppression and study response xenograft using spatial transcriptomics single-cell RNA sequencing. Human cells are uncommon in porcine cortex early after consist of primarily myeloid cells. Both...
Objective: To examine whether body mass index (BMI) changes modify the association between kidney donation and incident hypertension. Background: Obesity increases hypertension risk in both general living donor (LKD) populations. Donation-attributable context of obesity, weight change modifies that risk, is unknown. Methods: Nested case-control study among 1558 adult LKDs (1976–2020) with obesity (median follow-up: 3.6 years; interquartile range: 2.0–9.4) 3783 adults Coronary Artery Risk...
Abstract Pig-to-human xenotransplantation is rapidly approaching the clinical arena; however, it unclear which immunomodulatory regimens will effectively control human immune responses to pig xenografts. We transplanted a gene-edited kidney into brain-dead recipient on pharmacologic immunosuppression and studied response xenograft using spatial transcriptomics single-cell RNA sequencing. Human cells were uncommon in porcine cortex early after consisted of primarily myeloid cells. Both...
Current practice following injury within the United Kingdom is to receive surgery, at institution of first contact regardless ability provide timely intervention and inconsiderate neighbouring hospital resource capacity. This can lead a mismatch demand capacity, delayed surgery stress systems, particularly with regards elective services. We demonstrate through multicentre, multinational study, impact this scale.ORTHOPOD data collection period was between 22/08/2022 16/10/2022 consisted two...
Key Points Among obese living kidney donors, year of donation, preoperative body mass index, hypertension, and center percent donor transplants were associated with required predonation weight loss. There no significant differences in the likelihood loss requirement by race, sex, or age markers metabolic dysfunction. Background The proportion overweight/mildly donors (OLKDs) has increased past few decades, variation index (BMI) LKDs. purpose this study was to examine factors among OLKDs...
Approval of living kidney donors (LKD) with end-stage disease (ESKD) risk factors, such as obesity, has increased. While lifetime ESKD development data are lacking, the study intermediate outcomes diabetes is critical for LKD safety. Donation-attributable among persons obesity remains unknown. The purpose this was to evaluate 10-year diabetes-free survival LKDs and non-donors obesity.
Cell Transplantation - The Regenerative Medicine Journal converted to OA, according an announcement today by the journal's editors.