A5047409415- Corneal surgery and disorders
- Retinal and Optic Conditions
- Corneal Surgery and Treatments
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Pregnancy and preeclampsia studies
- Retinal Diseases and Treatments
- Retinopathy of Prematurity Studies
- Renal and Vascular Pathologies
- Cell Adhesion Molecules Research
- Respiratory Support and Mechanisms
- Ophthalmology and Visual Health Research
- Retinal and Macular Surgery
- COVID-19 Clinical Research Studies
- Facial Trauma and Fracture Management
- Traumatic Ocular and Foreign Body Injuries
- Trauma and Emergency Care Studies
- Ocular Diseases and Behçet’s Syndrome
- Connective Tissue Growth Factor Research
- Ocular Surface and Contact Lens
- Problem and Project Based Learning
- Connective tissue disorders research
- Acute Kidney Injury Research
- Healthcare Systems and Technology
- Skin and Cellular Biology Research
The California Eye Institute
2016-2023
University of Miami
2022-2023
University of Alabama at Birmingham
2022
Society of Critical Care Medicine
2021
University of California, Los Angeles
2017-2020
Doheny Eye Institute
2015-2020
Geisinger Medical Center
2020
Southern California Eye Institute
2016-2019
Smith-Kettlewell Eye Research Institute
2015
University of California, Davis
2011-2014
Introduction: Central retinal artery occlusions (CRAOs) and branch (BRAOs) are ophthalmic emergencies that require workups for systemic risk factors. In the acute setting, BRAOs present with whitening in a sectoral pattern on exam as well hyperreflectivity thickening of inner layers optical coherence tomography (OCT). subacute to chronic phase, dissipates, which may confound diagnosis remote arterial if there is no clearly visible plaque. Case Presentations: A 66-year-old male presented...
Abstract Previous studies demonstrate that skin wounds generate epinephrine (EPI) can activate local adrenergic receptors (ARs), impairing healing. Bacterially derived activators of Toll-like (TLRs) within the wound initiate inflammatory responses and also impair In this study, we examined hypothesis these two pathways crosstalk to one another, using EPI macrophage-activating lipopeptide-2 (MALP2) ARs TLR2, respectively, in human bone marrow-derived mesenchymal stem cells (BM-MSCs) neonatal...
Purpose: To investigate the molecular basis of posterior polymorphous corneal dystrophy (PPCD) by examining PPCD transcriptome and effect decreased ZEB1 expression on endothelial cell (CEnC) gene expression. Methods: Next-generation RNA sequencing (RNA-seq) analyses endothelium from two PPCD-affected individuals (one with PPCD3 one unknown genetic cause) compared age-matched controls, primary human CEnC (pHCEnC) transfected siRNA-mediated knockdown. The selected differentially expressed...
To assess the feasibility of imaging extremely low birth weight infants, defined as infants born weighing less than 1000 g or before 27 weeks gestational age, with an arm-mounted optical coherence tomography angiography (OCTA) device.Cross-sectional case series conducted at a single site in-patient academic center. Subjects included who had been premature and met ROP screening criteria. Birth history such age were collected. imaged OCTA in supine position during treatment. Segmental errors...
To report identification of a COL17A1 mutation in family with corneal dystrophy previously mapped to chromosome 10q23-q24.Whole-exome sequencing was performed on DNA samples from five affected members and two unrelated, unaffected individuals. Identified variants were filtered for those that were: located the linked interval 10q23-q24; novel or rare (minor allele frequency ≤0.01); heterozygous; present all individuals not controls; genes encode proteins expressed human epithelial cells...
Purpose. To report the identification of first de novo UBIAD1 missense mutation in an individual with Schnyder corneal dystrophy (SCD). Methods. A slit lamp examination was performed on a 47-year-old woman without family history disorders. The proband’s parents, two sisters, and son were also examined genomic DNA from all six individuals collected. exons exon-intron boundaries screened using Sanger sequencing. Identified mutations for 200 control chromosomes. In silico analysis predicted...
Current practice following injury within the United Kingdom is to receive surgery, at institution of first contact regardless ability provide timely intervention and inconsiderate neighbouring hospital resource capacity. This can lead a mismatch demand capacity, delayed surgery stress systems, particularly with regards elective services. We demonstrate through multicentre, multinational study, impact this scale.ORTHOPOD data collection period was between 22/08/2022 16/10/2022 consisted two...
Purpose: To investigate the role of zinc finger e-box binding homeobox 1 (ZEB1) transcription factor in posterior polymorphous corneal dystrophy 3 by demonstrating its ability to regulate type IV collagen gene via putative E2 box motifs. Methods: Putative motifs were identified silico analysis within promoter region collagen, IV, alpha3 (COL4A3) and alpha4 (COL4A4). test ZEB1 bind each box, electrophoretic mobility shift assays performed incubating ZEB1-enriched nuclear extracts with...
Log in or Register Subscribe to journalSubscribe Get new issue alertsGet alerts Enter your Email address: Wolters Kluwer Health may email you for journal and information, but is committed maintaining privacy will not share personal information without express consent. For more please refer our Privacy Policy. eTOC Secondary Logo Journal All Articles Images Videos Podcasts Blogs Advanced Search Toggle navigation Login & Issues Current IssuePrevious IssuesPublished Ahead-of-PrintSpecial...
Purpose: To study maternal retinal changes in pregnancies that resulted a small for gestational age (SGA) infant. Methods: Pregnant women with SGA infants at birth and age-matched pregnant appropriate (AGA) (controls) were enrolled. All subjects underwent spectral domain optical coherent tomography angiography (OCTA) imaging using 10° × scan pattern centered on the fovea. Vessel density (VD) vessel length (VLD) of superficial capillary plexus (SCP), intermediate (ICP), deep (DCP) analyzed...
Abstract Objectives Human kidney injury molecule 1 (hKIM-1) is a sensitive and specific marker for detection of clear cell renal carcinoma (CRCC), papillary (PRCC), ovarian (OCCC). Its use was limited to few surgical pathology laboratories because this antibody hKIM-1 not commercially available. We investigated the diagnostic utility RNA in situ hybridization/RNAscope tumors from various organs. Methods RNAscope performed on 1,252 cases tissue microarray sections, including CRCC (n = 185),...
Purpose: To characterize changes in retinal perfusion during pregnancy and the postpartum period using optical coherence tomography angiography (OCTA). Methods: A nonmydriatic OCTA camera was used to image healthy women who were pregnant or along with nonpregnant controls. Perfusion density (PD) vessel length (VLD) superficial capillary plexus (SCP), intermediate (ICP), deep (DCP) evaluated. Results: total of 16, 15, 13 eyes from nonpregnant, pregnant, subjects, respectively, When compared...
The purpose of the current study is to report outcomes suprachoroidal hemorrhage (SCH) after anterior segment surgery at a single institution, and identify clinical features associated with visual prognosis.Retrospective consecutive case series patients SCH occurring surgery.The includes 112 eyes between 2014 2020. There were 76 cases non-appositional versus 36 appositional SCH. mean presenting acuity for was 2.03 logMAR (SD 0.78) 2.39 0.43), respectively. Visual generally remained poor last...
This report describes a unique case of Coats-like presentation familial exudative vitreoretinopathy in an 11-year-old girl. The patient was originally referred for evaluation presumed Coats disease and presented with telangiectatic vessels, perivascular exudates, diffuse peripheral exudation, intraretinal hemorrhages. Clinical angiographical findings were consistent vitreoretinopathy, while genetic testing identified variants uncertain significance two associated genes, LRP5 ZNF408 . In...