A5101630084- Cancer Immunotherapy and Biomarkers
- Prostate Cancer Treatment and Research
- Immunotherapy and Immune Responses
- Heart Failure Treatment and Management
- IL-33, ST2, and ILC Pathways
- Prostate Cancer Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Diet and metabolism studies
- RNA modifications and cancer
- Hormonal Regulation and Hypertension
- Birth, Development, and Health
- Asthma and respiratory diseases
- Cytokine Signaling Pathways and Interactions
- Muscle metabolism and nutrition
- Cancer-related molecular mechanisms research
Fourth Affiliated Hospital of Harbin Medical University
2021-2023
Harbin Medical University
2021-2023
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
2022
Fred Hutch Cancer Center
2022
Mayo Clinic
2008
Hebei Medical University
2006
Foundation for Human Potential
2006
Advanced prostate malignancies are a leading cause of cancer-related deaths in men, large part due to our incomplete understanding cellular drivers disease progression. We investigate cancer cell dynamics at single-cell resolution from onset the development androgen independence an vivo murine model. observe expansion castration-resistant intermediate luminal type that correlates with treatment resistance and poor prognosis human patients. Moreover, transformed epithelial cells associated...
Animal studies showed glucocorticoids could specifically dilate renal vasculature, regulate synthesis and release of atrial natriuretic peptide (ANP), upregulate ANP receptors on vascular endothelial cells, thus have potent potentiating diuresis natriuresis effects in animal studies; however, their diuretic efficacy humans is yet to be known. Therefore, we designed this randomized, double- blind, placebo-controlled, clinical study determine the prednisone, a glucocorticoid, patients with...
It has been reported that airway epithelial cells and ferroptosis have certain effect on asthma. However, the action mechanism of ferroptosis-related genes in asthmatic patients is still unclear. Firstly, study downloaded GSE43696 training set, GSE63142 validation set GSE164119 (miRNA) dataset from gene expression omnibus database. 342 were Moreover, differentially expressed (DEGs) between asthma control samples screened by differential analysis. Consensus clustering analysis was performed...
Rationale: Severe asthma is a heterogeneous disease with multiple molecular mechanisms. Gene expression studies of asthmatic bronchial epithelial cells have provided biological insights and underscored possible pathological mechanisms; however, the basis in severe still poorly understood. Objective: The objective this study was to identify features uncover distinct phenotype. Methods: k-means clustering differentially expressed genes (DEGs) were performed 129 individuals Asthma Research...