A5020232159- Osteoarthritis Treatment and Mechanisms
- Bone fractures and treatments
- Periodontal Regeneration and Treatments
- Orthopaedic implants and arthroplasty
- Knee injuries and reconstruction techniques
- Wound Healing and Treatments
- Bone health and osteoporosis research
- Mesenchymal stem cell research
- Shoulder Injury and Treatment
- E-commerce and Technology Innovations
- Shoulder and Clavicle Injuries
- Spine and Intervertebral Disc Pathology
- Orthopedic Infections and Treatments
- Tendon Structure and Treatment
- Textile materials and evaluations
- Lower Extremity Biomechanics and Pathologies
- Dental Implant Techniques and Outcomes
- Electrospun Nanofibers in Biomedical Applications
- Total Knee Arthroplasty Outcomes
- Medical Imaging and Analysis
- Neonatal Respiratory Health Research
- Genetics and Physical Performance
- Trauma Management and Diagnosis
- Planarian Biology and Electrostimulation
- Magnesium Alloys: Properties and Applications
University of Zurich
2020-2025
Lehigh University
2023
École Polytechnique Fédérale de Lausanne
2011-2013
University Hospital of Lausanne
2009-2013
Center for Pediatric Endocrinology Zurich
2009
Aims The “2 to 10% strain rule” for fracture healing has been widely interpreted mean that interfragmentary greater than predisposes a nonunion. This interpretation focuses on the gap-closing (axial micromotion divided by gap size), ignoring region around where osteogenesis typically initiates. aim of this study was measure and 3D strains in plated ovine osteotomies associate local conditions with callus mineralization. Methods MicroCT scans eight female sheep mid-shaft tibial were used...
Osteoarthritis (OA) is the most prevalent joint disorder, causing pain and disability predominantly in aging population but also affecting young individuals. Current treatments are limited to use of anti-inflammatory drugs alleviate symptoms or degenerated replacement by a prosthetic implant at end stage disease. We hypothesized that degenerative cartilage defects can be treated using nasal chondrocyte–based tissue-engineered (N-TEC). demonstrate N-TEC maintained cartilaginous properties...
Bone fractures commonly repair by forming a bridging structure called callus, which begins as soft tissue and gradually ossifies to restore rigidity the bone. Virtual mechanical testing is promising technique for image-based assessment of structural bone healing in both preclinical clinical settings, but its accuracy depends on validity material model used assign properties. The goal this study was develop constitutive callus that captures heterogeneity biomechanical duality contains woven...
Articular cartilage regeneration poses particularly tough challenges for implementing cell-based therapies. Many cell types have been investigated looking a balanced combination of responsiveness and stability, yet techniques are still far from defining gold standard. The work presented focuses on the reliable expansion characterization clinical grade human epiphyseal chondroprogenitor (ECP) bank single tissue donation. A parental ECP was established, which provides seed material master...
Wound healing involves complex mechanisms, which, if properly chaperoned, can enhance patient recovery. The abilities of platelets and keratinocytes may be harnessed in order to stimulate wound through the formation platelet clots, release several growth factors cytokines, cell proliferation. aim study was test whether autologous keratinocyte suspensions concentrate would improve healing. conducted at Lausanne University Hospital, Switzerland 45 patients, randomized three different topical...
Finite element analysis with models derived from computed tomography (CT) scans is potentially powerful as a translational research tool because it can achieve what animal studies and cadaver biomechanics cannot-low-risk, noninvasive, objective assessment of outcomes in living humans who have actually experienced the injury, or treatment being studied. The purpose this study was to assess validity CT-based virtual mechanical testing respect physical biomechanical tests large model. Three...
Objective Hyaluronic acid–transglutaminase (HA-TG) is an enzymatically crosslinkable adhesive hydrogel with chondrogenic properties demonstrated in vitro and ectopic mouse model. In this study, we investigated the feasibility of using HA-TG a collagen scaffold to treat chondral lesions ovine model, evaluate cartilage regeneration mechanically biologically challenging joint environment, influence surgical procedure on repair process. Design Chondral defects 6-mm diameter were created stifle...
Abstract Background Therapies using electromagnetic field technology show evidence of enhanced bone regeneration at the fracture site, potentially preventing delayed or nonunions. Methods Combined electric and magnetic (CEMF) treatment was evaluated in two standardized sheep tibia osteotomy models: a 3-mm non-critical size gap model 17-mm critical defect augmented with autologous grafts, both stabilized locking compression plates. CEMF delivered across twice daily for 90 min, starting 4 days...
Background: Arthroscopic repair of large rotator cuff tendon tears is associated with high rates retear. Construct failure often occurs at the suture-tendon interface. Patch augmentation can improve mechanical strength and healing this Purpose: To introduce a novel technique for suture-free attachment an overlaid patch evaluate its biomechanical biological performance. Study Design: Descriptive controlled laboratory studies. Methods: An established ovine model partial infraspinatus resection...
Tendon defects require multimodal therapeutic management over extensive periods and incur high collateral burden with frequent functional losses. Specific cell therapies have recently been developed in parallel to surgical techniques for managing acute degenerative tendon tissue affections, optimally stimulate resurgence of structure function. Cultured primary human fetal progenitor tenocytes (hFPT) preliminarily considered allogeneic homologous therapies, characterized as stable,...
Abstract In large animal studies, the mechanical reintegration of bone fragments is measured using postmortem physical testing, but these assessments can only be performed once, after sacrifice. Image‐based virtual testing an attractive alternative because it could used to monitor healing longitudinally. However, procedures and software required perform finite element analysis (FEA) on subject‐specific models for time consuming costly. Accordingly, goal this study was determine whether a...
Diverse cell therapy approaches constitute prime developmental prospects for managing acute or degenerative cartilaginous tissue affections, synergistically complementing specific surgical solutions. Bone marrow stimulation (i.e., microfracture) remains a standard technique cartilage repair promotion, despite incurring the adverse generation of fibrocartilagenous scar tissue, while matrix-induced autologous chondrocyte implantation (MACI) and alternative cell-based may partly circumvent this...
Cytotherapies are often necessary for the management of symptomatic large knee (osteo)-chondral defects. While autologous chondrocyte implantation (ACI) has been clinically used 30 years, allogeneic cells (clinical-grade FE002 primary chondroprogenitors) have investigated in translational settings (Swiss progenitor cell transplantation program). The aim this study was to comparatively assess and approaches (quality, safety, functional attributes) cell-based chondrotherapies developed...
The goal of this study was to develop an image analysis algorithm for quantifying the effects remodelling on cortical bone during early fracture healing. An adaptive thresholding technique with boundary curvature and tortuosity control developed automatically identify endocortical pericortical boundaries in presence high-gradient mineral density (BMD) near healing zone. successfully detected more than 47,000 microCT images from 12 pairs ovine osteotomies intact contralateral tibiae....
Significance: The highest absorption peaks of the main components bone are in mid-infrared region, making Er:YAG and CO2 lasers most efficient for cutting bone. Yet, studies deep ablation minimally invasive settings very limited, as finding suitable materials coupling high-power laser light with low attenuation beyond 2 μm is not trivial. Aim: first aim this study was to compare performance different optical fibers terms transmitting a 2.94-μm wavelength at high pulse energy close 1 J....
Abstract Background and Aims Autologous keratinocyte sheets constitute an important component of the burn wound treatment toolbox available to a surgeon can be considered life‐saving procedure for patients with severe burns over 50% their total body surface area. Large‐scale sheet cultivation still fundamentally relies on use animal components such as inactivated murine 3T3 fibroblasts feeders, animal‐derived enzymes trypsin, well media fetal bovine serum (FBS). This study was therefore...
The cause, extent, and role of muscle edema for degeneration are unknown not considered in the current literature. In vivo experiments were designed to prove formation early period a sheep model acute rotator cuff tears.Muscle occurs after tendon release with or without additional stretching trauma may be associated retraction subsequent degeneration.Controlled laboratory study.A infraspinatus was used. An osteotomy greater tuberosity, including insertion tendon, performed 14 sheep. To...
Abstract Orthopedic implant-associated bacterial infections with Staphylococcus aureus constitute a major clinical problem, and large pre-clinical animal models remain scarce. The aim of this study was to establish standardized method localized, acute S. bone infection in the presence complex implanted devices sheep model. Four underwent surgery receiving metallic device component stabilizing defect created left tibial metaphysis, an attached placed adjacent soft tissue. inoculated strain...
Background: Muscle edema formation and inflammatory processes are early manifestations of acute rotator cuff lesions in sheep. Histological analysis affected muscles revealed formation, changes, muscle tissue disruption MRs. Hypothesis: Edema contributes to reactions fiber degeneration before the onset fatty infiltration. Study Design: Controlled laboratory study. Methods: Osteotomy greater tuberosity, including insertion infraspinatus tendon, was performed on 14 These experimental animal...