A5032710816- Plant Molecular Biology Research
- Plant nutrient uptake and metabolism
- RNA modifications and cancer
- Plant and animal studies
- Plant Reproductive Biology
- Ecology and Vegetation Dynamics Studies
- Plant Pathogens and Fungal Diseases
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Genetic Mapping and Diversity in Plants and Animals
- Heavy Metal Exposure and Toxicity
- Plant Stress Responses and Tolerance
- Pregnancy and Medication Impact
- Single-cell and spatial transcriptomics
- Blood properties and coagulation
- Epigenetics and DNA Methylation
- Trace Elements in Health
- Legume Nitrogen Fixing Symbiosis
- Mobile Agent-Based Network Management
- Law, logistics, and international trade
- Virtual Reality Applications and Impacts
- Maternal and fetal healthcare
- Radiomics and Machine Learning in Medical Imaging
- RFID technology advancements
- Plant Gene Expression Analysis
Peking University
2010-2024
Peking University Third Hospital
2022-2024
Max Planck Institute for Biology
2022-2024
Chang'an University
2024
King University
2023
China Three Gorges University
2023
Harbin Medical University
2023
Fujian Agriculture and Forestry University
2023
Shanghai Sixth People's Hospital
2023
Hubei University
2023
The BRCA1 tumor suppressor forms a heterodimer with the BARD1 protein, and resulting complex functions as an E3 ubiquitin ligase that catalyzes synthesis of polyubiquitin chains. In theory, polyubiquitination can occur by isopeptide bond formation at any seven lysine residues ubiquitin. linkage chain is particularly important determinant its cellular function, such K48-linked chains commonly target proteins for proteasomal degradation, while K63 serve non-proteolytic roles in various...
Abstract R-loops, which consist of a DNA/RNA hybrid and displaced single-stranded DNA (ssDNA), are increasingly recognized as critical regulators chromatin biology. R-loops particularly enriched at gene promoters, where they play important roles in regulating expression. However, the molecular mechanisms that control promoter-associated remain unclear. The epigenetic ‘reader’ Tudor domain-containing protein 3 (TDRD3), recognizes methylarginine marks on histones C-terminal domain RNA...
Cardiac fibrosis is a common pathological manifestation in multiple cardiovascular diseases and often results myocardial stiffness cardiac dysfunctions. LncRNA (long noncoding RNA) participates number of pathophysiological processes. However, its role remains unclear. The purpose this study was to investigate the molecular mechanism MetBil regulating fibrosis. Our data showed that METTL3 binding lncRNA (MetBil) significantly increased both fibrotic tissue following infarction (MI) mice...
Abstract DNA methylation patterns in plants are dynamically regulated by and active demethylation response to both environmental changes development of plant. Beginning with the removal methylated cytosine ROS1/DME family 5-methylcytosine glycosylases, occurs through base excision repair. So far, many components involved remain undiscovered. Through a forward genetic screening Arabidopsis mutants showing hypermethylation at EPF2 promoter region, we identified conserved iron-sulfur cluster...
Idiopathic Pulmonary Fibrosis (IPF) is a progressive interstitial lung disease characterized by unknown etiology and limited therapeutic options. Recent studies implicate exosomal non-coding RNAs (ncRNAs) as crucial regulators in IPF. These ncRNAs, including long (lncRNAs), microRNAs (miRNAs), circular (circRNAs), are involved cellular processes through various mechanisms of selective packaging, intercellular communication, signaling pathway integration. LncRNAs such LINC00470 PVT1 exhibit...
Understanding the mechanisms that underlie plant invasions is critical for management and conservation of biodiversity. At same time, invasive species also provide a unique opportunity to study rapid adaptation complex environmental conditions. Using four replicate reciprocal transplant experiments across three habitats, we described patterns phenotypic response assessed degree local in knotweed populations. We found plants from beach habitats were generally smaller than marsh roadside when...
Methylation is one of the common forms RNA modification, which mainly include N6-methyladenosine (m6A), C5-methylcytidine (m5C), and N1-methyladenosine (m1A). Numerous studies have shown that methylation associated with tumor development. We aim to construct prognostic models gastric cancer based on regulators.The transcriptome clinical data normal samples were obtained from National Cancer Institute Genome Data Commons (NCI-GDC). Use Least Absolute Shrinkage Selection Operator (LASSO) Cox...
Climate change has already caused noticeable changes in species-wide traits, such as the well-documented acceleration of spring flowering. Because evolutionary past favored certain combinations some strategies like fast growth with early flowering that are adaptive today at odds other plant resilience elevated water use efficiency. We know evolution trait is shaped by genomic constraints, but it unclear whether and how this affected natural selection from climate change. Growing hundreds...
Despite its conserved role on gene expression and transposable element (TE) silencing, genome-wide CG methylation differs substantially between wild Arabidopsis thaliana accessions.
Pregnant women of advanced maternal age (AMA) are vulnerable to exposure the surrounding environment. Assessment trace elements in pregnant living specific areas is important for biomonitoring. However, levels and variation patterns during pregnancy remains controversial attracts extensive public concern. Therefore, we aimed evaluate 18 toxic and/or essential plasma paired cord at AMA. A total 48 AMA were recruited Peking University Third Hospital from 2018 2021. Eighteen found 1st, 2nd, or...
Complex traits, such as growth and fitness, are typically controlled by a very large number of variants, which can interact in both additive non-additive fashion. In an attempt to gauge the relative importance types genetic interactions, we turn hybrids, provide facile means for creating many novel allele combinations.We focus on interaction between alleles same locus, i.e., dominance, perform transcriptomic study involving 141 random crosses different accessions plant model species...
As a homologue of the angiotensin-converting enzyme (ACE), 2 (ACE2) has been identified as main receptor for severe acute respiratory syndrome coronavirus (SARS-CoV-2) invasion. We aimed to investigate role serum ACE in predicting disease 2019 (COVID-19) progression and underlying mechanisms. retrospectively enrolled 120 patients with confirmed COVID-19 who underwent detection on admission. The clinical characteristics laboratory findings during hospitalization were evaluated dynamically...
Transesophageal echocardiography (TEE) is a well-established method for detecting and diagnosing heart tumors. In contrast, its role in assessing the presence, growth evidence of malignant tumors originating from mediastinal sites remains unclear. The aim this study was to compare diagnostic impact TEE transthoracic (TTE) determining localization, malignancy adult (MTs).In prospective investigator-blinded study, we evaluated 144 consecutive patients with MT lesions assess TTE presence...
The study of mutants is one the best tools for understanding genetic basis phenotypes that contribute to adaptation. Oddly, mutant analyses are almost always restricted single backgrounds and findings therefore can not be easily generalized. A case in point key regulator flowering, FLOWERING LOCUS C ( FLC ), which has been inferred explain much flowering time variation Arabidopsis thaliana , yet have examined very few backgrounds. We previously established a set panspecific flc 62 accessions...
Abstract When plants defend themselves from pathogens, this often comes with a trade-off: the same genes that protect plant disease can also reduce its growth and fecundity in absence of pathogens. One protein implicated major growth-defense trade-off Arabidopsis thaliana is ACCELERATED CELL DEATH 6 (ACD6), an ion channel modulates salicylic acid (SA) synthesis to potentiate wide range defenses. Wild populations maintain significant functional variation ACD6 gene, some alleles making...
ABSTRACT Introduction The increase in fibrinogen levels is vital for the formation of a prothrombotic state during gestation to counter‐bleeding challenges at delivery. However, pregnancy complications characterized by systemic inflammatory response syndrome may consume fibrinogen, resulting elevated D‐dimer levels. Methods Our study based on total 16 768 pregnant women who delivered between December 1, 2013, and 2018, changes under normal multiples pathogenic states. Result Compared with...
Abstract Understanding the mechanisms that underlie plant invasions is critical for management and conservation of biodiversity. At same time, invasive species also provide a unique opportunity to study rapid adaptation complex environmental conditions. Using four replicate reciprocal transplant experiments across three habitats, we described patterns phenotypic response assessed degree local in knotweed populations. We found plants from beach habitats were generally smaller than marsh...
ABSTRACT PREMISE Many plant invaders like the Japanese knotweeds are thought to colonize new habitats with low genetic diversity. Such species provide an opportunity study rapid adaptation complex environmental conditions. METHODS Using replicate reciprocal transplants of clones across three habitats, we described patterns phenotypic response and assessed degree local adaptation. KEY RESULTS We found plants from beach had decreased height, number leaves, leaf area, biomass allocation roots...
Objective:To investigate the accuracy of terahertz system in differentiating hypopharyngeal cancer from normal tissue and its role determining pathological incised margin cancer. Method:The transplantation model 5-week-old male BALB/c nude mice were established by subcutaneous injection. The obtained transplanted tumor specimens pathologically diagnosed to determine extent tissue. Tumor tissue, paracellular scanned time-domain spectroscopy. differential spectral data through detection frozen...