A5005693943- Parkinson's Disease Mechanisms and Treatments
- Cleft Lip and Palate Research
- Craniofacial Disorders and Treatments
- Prostate Cancer Treatment and Research
- Neurological disorders and treatments
- Telemedicine and Telehealth Implementation
- Advanced Proteomics Techniques and Applications
- Assistive Technology in Communication and Mobility
- Genomic variations and chromosomal abnormalities
- Genetic Neurodegenerative Diseases
- Mass Spectrometry Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- CRISPR and Genetic Engineering
- Cancer Cells and Metastasis
- Mobile Health and mHealth Applications
- Reconstructive Surgery and Microvascular Techniques
- Nerve injury and regeneration
- Cancer survivorship and care
- Alzheimer's disease research and treatments
- Genetic Associations and Epidemiology
- Community Health and Development
- Patient Dignity and Privacy
- Vascular Procedures and Complications
- Chronic Disease Management Strategies
- Healthcare Systems and Technology
Georgetown University Medical Center
2024
Georgetown University
2024
Washington University Medical Center
2023
University of California, San Diego
2017-2022
Washington University in St. Louis
2022
National Institute of Neurological Disorders and Stroke
2021
National Institutes of Health
2021
La Jolla Alcohol Research
2017-2019
Creative Commons
2019
Uniformed Services University of the Health Sciences
2018
<b><i>Background:</i></b> Clinician rating scales and patient-reported outcomes are the principal means of assessing motor symptoms in Parkinson disease Huntington disease. However, these assessments subjective generally limited to episodic in-person visits. Wearable sensors can objectively continuously measure features could be valuable clinical research care. <b><i>Methods:</i></b> We recruited participants with disease, prodromal...
To determine whether providing remote neurologic care into the homes of people with Parkinson disease (PD) is feasible, beneficial, and valuable.
Abstract PRKN mutations are the most common recessive cause of Parkinson’s disease and a promising target for gene cell replacement therapies. Identification biallelic patients at population scale, however, remains challenge, as roughly half copy number variants many single nucleotide polymorphisms unclear significance. Additionally, true prevalence risk associated with heterozygous is unclear, comprehensive assessment has not been performed scale. To address these challenges, we evaluated...
Background:Delivering specialty care remotely directly into people's homes can enhance access for and improve the healthcare of individuals with chronic conditions. However, evidence supporting this approach is limited.Materials Methods:Connect.Parkinson a randomized comparative effectiveness study that compares usual Parkinson's disease in community augmented by virtual house calls specialist from 1 18 centers nationally. Individuals intervention arm receive four visits over year via...
Previous small-scale studies have demonstrated the feasibility of providing remote specialty care via virtual visits. We assessed and benefits a one-time consultation between Parkinson Disease (PD) specialist an individual with PD at home on larger scale.We conducted multicenter noncontrolled cohort visits administered over videoconferencing specialists individuals in their home. Specialists performed patient history PD-specific physical examination provided recommendations to patients local...
Severe early life stressors increase the probability of developing psychiatric disorders later in through modifications neuronal circuits controlling brain monoaminergic signaling. Our previous work demonstrated that 24 h maternal deprivation (MD) male Sprague Dawley rats modifies dopamine (DA) signaling from ventral tegmental area (VTA) changes at GABAergic synapses were reversible by vitro histone deacetylase (HDAC) inhibition which led to restoration scaffold A-kinase anchoring protein...
Abstract Background Cytoplasmic inclusions of α‐synuclein (α‐syn) in brainstem neurons are characteristic idiopathic Parkinson's disease (PD). PD also entails α‐syn buildup sympathetic nerves. Among genetic forms PD, the relative extents intraneuronal accumulation have not been reported. Objective This cross‐sectional observational study compared magnitudes deposition common and rare PD. Methods α‐Syn was quantified by α‐syn‐tyrosine hydroxylase colocalization index C2 cervical skin biopsies...
For many types of surgical cases, there is an increase in length with the participation a resident physician. The lost operative time productivity not necessarily mitigated any fashion other than to benefit experience trainee. Moreover, increasing pressures maximize productivity, coupled diminishing reimbursements serve disincentive involvement. aim this study was examine opportunity cost academic setting for intraoperative during specific hand surgery cases.Retrospective analysis performed...
The limitations of the soft-tissue envelope, devascularized bone grafts, and relapse deformity are important considerations in surgical treatment unicoronal craniosynostosis. authors report their technique evolution distraction osteogenesis for patients with craniosynostosis.Open anterior cranial vault reconstruction combined internal was used, aid virtual planning. Technique included maximizing flap perfusion by means limited rotational osteotomies, preservation dural attachments. Clinical...
Advanced prostate cancer (PCa) patients with bone metastases are treated androgen pathway directed therapy (APDT). However, this treatment invariably fails and the becomes castration resistant. To elucidate resistance mechanisms to provide a more predictive pre-clinical research platform reflecting tumor heterogeneity, we established organoids from patient-derived xenograft (PDX) model of metastatic cancer, PCSD1. APDT-resistant PDX-derived (PDOs) emerged when cultured without or...
Abstract Tau is a microtubule‐associated protein implicated in Alzheimer's disease (AD) and other neurodegenerative disorders termed tauopathies. Pathological, aggregated forms of tau form neurofibrillary tangles (NFTs), impairing its ability to stabilize microtubules promoting neurotoxicity. Indeed, NFTs correlate with neuronal loss cognitive impairment. Hyperphosphorylation seen all tauopathies mirrors progression, suggesting an essential role pathogenesis. However, hyperphosphorylation...
The landscape of surgical and medical management patient choices for breast cancer treatment changes as reconstruction oncoplastic approaches improve diversify. Increased access to reconstruction, in addition education, influences the patient. Therefore, examination possible impact reconstructive surgery on all stages per se seemed timely.Plastic consults were arranged 520 new patients diagnosed with (2012-2016) including noninvasive but at high risk further development. To test plastic...
Introduction Methods of reporting quantitative results for distraction osteogenesis (DO) craniosynostosis have been inconsistent. Therefore, the efficacy differing techniques and timing in regard to volume change is not well established, with no uniform metric comparisons. Given that cranial vault remodeling DO may be completed different approaches, analysis was made determine (1) relative efficiency approaches expanding intracranial (ICV) (2) impact adjusting ICV growth on measured...
PURPOSE: Management of patients with unilateral or bilateral complete cleft lip and palate using early soft closure at the time repair followed by hard 10–18 months old has been advocated for improving speech audiology outcomes, although this not previously investigated. This study performs a comparative review outcomes single-stage 2-stage repairs associated palate. MATERIALS AND METHODS: A retrospective chart identified diagnosis who underwent either single from 2006 to 2012. Data...
ABSTRACT PRKN mutations are the most common recessive cause of Parkinson’s disease (PD) and a promising target for gene cell replacement therapies. Identification biallelic patients (PRKN-PD) at population scale, however, remains challenge, as roughly half copy number variants (CNVs) many single nucleotide polymorphisms (SNPs) unclear significance. Additionally, true prevalence risk associated with heterozygous is unclear, comprehensive assessment SNPs CNVs has not been performed scale. To...
Summary: The reconstruction of distal extremity wounds poses a unique surgical challenge. In free tissue transfer, thin, pliable skin flap is the ideal. Obese patients have paucity thin donor sites. Herein we report discovery SHRIMP (Superthin Harvest Reliable Islanded Medial Pannus flap) based on SIEA vessels, harvested from thick abdominal pannus at time cosmetic abdominoplasty. A 61-year-old woman with chronic wound right Achilles tendon was evaluated for after failing conservative...
You have accessJournal of UrologyProstate Cancer: Basic Research & Pathophysiology III (MP81)1 Apr 2019MP81-19 MECHANISMS OF ANTI-ANDROGEN RESISTANCE IN A 3D PATIENT-DERIVED ORGANOID MODEL BONE METASTATIC PROSTATE CANCER Danielle Burner*, Theresa Mendoza, Michelle Muldong, Sanghee Lee, Catalina Arreola, Olga Miakicheva-Greenburg, William Zhu, Christina Wu, Nicholas Cacalano, Catriona Jamieson, Christopher Kane, Anna Kulidjian, and Jamieson Burner*Danielle Burner* More articles by this author...
Purpose: Although numerous publications have described distraction osteogenesis (DO) for craniosynostosis, methods of reporting quantitative results been inconsistent. Therefore, the efficacy anterior DO and posterior in regards to volume change is not well established. We report a metric that relates length our analysis ICV by osteogenesis. Methods: Patients with craniosynostosis were treated open cranial vault reconstruction combined internal distraction. Preoperative postoperative CT...