A5026428280- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Glycogen Storage Diseases and Myoclonus
- Botulinum Toxin and Related Neurological Disorders
- Neurological diseases and metabolism
- Telemedicine and Telehealth Implementation
- Obsessive-Compulsive Spectrum Disorders
- Neurogenetic and Muscular Disorders Research
- Hereditary Neurological Disorders
- Parkinson's Disease and Spinal Disorders
- Amyotrophic Lateral Sclerosis Research
- Mitochondrial Function and Pathology
- Muscle Physiology and Disorders
- Multiple Sclerosis Research Studies
- Neurology and Historical Studies
- Neurological and metabolic disorders
- Nuclear Receptors and Signaling
- Dysphagia Assessment and Management
- Body Image and Dysmorphia Studies
- Metabolism and Genetic Disorders
- Autism Spectrum Disorder Research
- Restless Legs Syndrome Research
- Psychosomatic Disorders and Their Treatments
- Balance, Gait, and Falls Prevention
Mayo Clinic
2014-2023
WinnMed
2011-2023
Beacon College
2023
Trinity College Dublin
2023
Mayo Clinic in Arizona
2013-2022
Justus-Liebig-Universität Gießen
2022
University of Duisburg-Essen
2022
Essen University Hospital
2022
University of Cologne
2022
Emory University
2021
To determine whether providing remote neurologic care into the homes of people with Parkinson disease (PD) is feasible, beneficial, and valuable.
Patients with corticobasal degeneration can present several different clinical syndromes, making ante-mortem diagnosis a challenge. Corticobasal syndrome is the phenotype originally described for degeneration, characterized by asymmetric rigidity and apraxia, cortical sensory deficits, dystonia myoclonus. Some patients do not develop these features, but instead have features consistent Richardson presentation of progressive supranuclear palsy, postural instability, early unexplained falls,...
Abstract Background In 2017, the International Parkinson and Movement Disorder Society put forward new clinical criteria for diagnosis of PSP, recognizing diverse PSP phenotypes. this study, we compared sensitivity specificity with National Institutes Neurological Disease Progressive Supranuclear Palsy at different times. Methods Patients parkinsonism, and/or neuropathological were identified from brain bank. All patients had neuropathologic diagnoses detailed examination performed by a...
To evaluate the clinical, electrophysiologic, and treatment outcome features of orthostatic tremor (OT) in a large case series.We performed medical record review 184 patients who met clinical electrodiagnostic criteria for OT from 1976 to 2013 at Mayo Clinic. Demographic, data were extracted.The majority cases female (63.6%) mean age onset was 59.3 years (range 13-85 years). Diagnosis delayed by 7.2 0-44 The average frequency 15.7 Hz 12.5-20 Hz), transmitted arms on weight-bearing (95.5%)....
This phase I/II study sought to explore intrathecal administration of mesenchymal stem cells (MSCs) as therapeutic approach multiple system atrophy (MSA).
The COVID-19 pandemic restricted usual healthcare management for movement-disorders patients, with a consequent upsurge in telemedicine to bridge the gap.To assess global usage context of pandemic.The Movement Disorder Society (MDS) Telemedicine Study Group surveyed experts from 40 countries across all continents March-April 2020. Four domains were assessed: legal regulations, reimbursement, clinical use, and barriers; comparing emerging responses versus baseline scenario.All forms movement...
Glycine receptor alpha-1 subunit (GlyRα1)-immunoglobulin G (IgG) is diagnostic of stiff-person syndrome (SPS) spectrum but has been reported detectable in other neurologic diseases for which significance less certain.To assess GlyRα1-IgGs as biomarkers SPS among patients and controls, specimens were tested using cell-based assays (binding [4°C] modulating [antigen endocytosing, 37°C]). Medical records seropositive reviewed.GlyRα1-IgG antibody) was detected 21 247 with suspected (8.5%) 8 190...
To describe a novel antibody biomarker of neurologic paraneoplastic autoimmunity specific for phosphodiesterase 10A (PDE10A), striatum-enriched phosphodiesterase, and to characterize the clinical phenotype patients with PDE10A immunoglobulin G (IgG).We 7 autoantibodies identified in Mayo Clinic Neuroimmunology Laboratory. Patient specimens (sera, 7; CSF, 4) produced identical basal ganglia-predominant synaptic staining murine brain tissue by indirect immunofluorescence. The autoantigen was...
To investigate the safety and efficacy of N-acetyl-L-leucine (NALL) on symptoms, functioning, quality life in pediatric (≥ 6 years) adult Niemann-Pick disease type C (NPC) patients.In this multi-national, open-label, rater-blinded Phase II study, patients were assessed during a baseline period, 6-week treatment period (orally administered NALL 4 g/day ≥ 13 years, weight-tiered doses for 6-12 years), post-treatment washout period. The primary Clinical Impression Change Severity (CI-CS)...
Progressive supranuclear palsy (PSP) is a neurodegenerative disorder pathologically characterized by neuronal loss, gliosis and tau-positive neurofibrillary tangles in basal ganglia, brainstem cerebellar nuclei. Five presenting clinical syndromes of PSP are well-described: (i) the classic Richardson's syndrome; (ii) asymmetric parkinsonism with tremor; (iii) freezing gait; (iv) limb apraxia, (v) apraxia speech.To determine whether autopsy-proven cases may present another phenotype.Medical...
Neurological illness brings pathos and shock but also an element of humanism. Thus, neurological disorders their vicissitudes—in particular, the more disabling afflictions—speak to imagination book screen writers. We wish describe our experience these art forms within Neurology Book Film Club at Mayo Clinic, Rochester, USA. Our ‘club’ was initiated in 2010 by neurology residents is supported attended residents, fellows consultant staff. hold a monthly event discuss or movie with theme,...
Background:Delivering specialty care remotely directly into people's homes can enhance access for and improve the healthcare of individuals with chronic conditions. However, evidence supporting this approach is limited.Materials Methods:Connect.Parkinson a randomized comparative effectiveness study that compares usual Parkinson's disease in community augmented by virtual house calls specialist from 1 18 centers nationally. Individuals intervention arm receive four visits over year via...
Background Patients with Parkinson disease (PD) are at high risk of hospital encounters increasing morbidity and mortality. This study aimed to determine the rate in a cohort followed over 5 years identify associated factors. Methods We queried data from International Multicenter National Foundation Quality Improvement study. Multivariate logistic regression backward selection was performed factors encounter prior baseline visit. Kaplan-Meier estimates were obtained Cox on time after Results...