Tescalcin (TESC; also known as calcineurin B homologous protein 3, CHP3) has recently reported a regulator of cancer progression. Here, we showed that the elevation TESC in non-small cell lung (NSCLC) intensifies epithelial-mesenchymal transition (EMT) and stem (CSC) properties, consequently enhancing cellular resistance to γ-radiation. expression phosphorylation (consequent activation) signal transducer activator transcription 3 (STAT3) were upregulated CSC-like ALDH1high cells than...

Transmembrane 4 L6 family proteins have been known to promote cancer. In this study, we demonstrated that transmembrane member (TM4SF4), which is induced by γ-radiation in non-small cell lung cancer (NSCLC) cells, involved epithelial-to-mesenchymal transition (EMT) and stem (CSC) properties of NSCLC through the regulation osteopontin (OPN). Forced TM4SF4 overexpression A549 cells increased secretion OPN, activates CD44 or integrin signaling thus maintains EMT-associated CSC-like properties....

ABSTRACT— Intrahepatic distribution of Lipiodol and I‐131 infused via the hepatic arteries was evaluated in six patients with HCC who had undergone lobectomy or segmentectomy. CT scan gamma camera radiograph confirmed that oily contrast material radioactivity accumulated selectively tumor over a long period. One to two thirds mass appeared necrotic, although extent tended be larger case radioactive infusion. The cells contained numerous lipid globules within cytoplasm. Also, oil red 0 stain...

As a part of an ongoing search for bioactive constituents from Korean medicinal plants, the phytochemical investigations twigs Salix glandulosa afforded 12 new phenolic glycosides (1–12) and known analogue (13). The structures 1–13 were characterized by combination NMR methods (1H 13C NMR, 1H–1H COSY, HMQC, HMBC), chemical hydrolysis, GC/MS. absolute configuration 13 [(1R,2S)-2-hydroxycyclohexyl-2′-O-trans-p-coumaroyl-β-d-glucopyranoside] was determined first time. Compounds 1–3, 6, 7...

Bone remodeling and homeostasis are largely the result of coordinated action osteoblasts osteoclasts. Osteoblasts responsible for bone formation. The differentiation is regulated by transcription factors, Runx2 Osterix. Natural products plant origin still a major part traditional medicinal systems in Korea. root Lithospermum erythrorhizon Sieb. et Zucc. (LR), purple gromwell, an herbal medicine used inflammatory infectious diseases. LR anti-inflammatory exerts anticancer effects inducing...

This study has been conducted to establish the optimal extraction process and HPLC analysis method for determination of marker compounds as a part materials standardization development health functional food from Astragali radix. Five conditions including shaking at room temperature reflux 85℃ with 30%, 50% 95% ethanol were evaluated. Reflux showed highest yield 27.27 ± 2.27%, while under significantly lowest 10.55 0.24%. The quantitative methods calycosin-7-O-β-D-glucoside calycosin radix...

This study investigates the effect of supercritical fluid extract (CMPB803-C) Lithospermum erythrorhizon,shikonin and acetylshikonin isolated from erythrorhizon on IL-1β-induced chondrocytes monosodium iodoacetate (MIA)-induced osteoarthritis in rat. Shikonin (50 μM) (3 treatment reduced significantly mRNA expression enzyme activity matrix metalloproteinase (MMP)-1, -3 -13 SW1353 chondrosarcoma cells. The chondro-protective effects CMPB803-C were than analyzed a rat OA model using single...

Background: Astragali radix (A) and Lithospermi (L) have long been used as traditional medicines due to their known anti-inflammatory effects. This study aimed at evaluating, optimal mixing ratio functional compounds by investigating the inhibitory effects of mixed extracts A L active on matrix metalloproteinases (MMPs).BRMethods Results: were obtained extraction 80℃ using 50% 70% fermented alcohol, respectively, then a 5 : 5, 6 4, 7 3 8 2 (w/w). The activities MMP-1, MMP-3, MMP-13 evaluated...

We report a case of nevus spilus with neurotized studied by immunohistochemical methods using S-100, leu-7, glial fibrillary acid protein (GFAP), and myelin basic (MBP). Histologic findings the speckled lesion showed irregular rete ridge elongation, increased epidermal melanocytes melanin in epidermis, scattered cell nests upper dermis, but deep which has many features neurofibroma. Diffuse expression S-100 MBP, focal staining GFAP, lack leu-7 were observed. Leu-7, positive only...

Lymphoepithelial cyst of the oral cavity is an uncommon cystic lesion lined with stratified squamous epithelium surrounded by lymphoid tissue. We report a case lymphoepithelial associated two large epithelial inclusion cysts.

This study was carried out to investigate the effects of Salvia plebeia R. Br. ethanolic extract with different aspects (stem/leaf and whole plant) on differentiation lipid accumulation in 3T3-L1 preadipocytes. The morphological changes degrees cells were measured by Oil Red O staining intra-cellular triglyceride (TG) assay. mRNA expressions special peroxisome proliferation activated receptor- genes (PPAR), CCAAT/ enhancer-binding protein (C/EBPα), fatty acid synthase (FAS) lipoprotein...

Background: In the present study, we established an HPLC (high performance liquid chromatography)-analysis method for determination of marker compounds as a part material standardization development health-functional foods from Salvia plebeia R. Br. extract. Methods and Results: The quantitative hispidulin compound was optimized by analysis using YMC hydrosphere C18 column with gradient elution system. This validated specificity, linearity, accuracy, precision tests. It showed high linearity...

As advancements in display technology persist, ongoing research endeavors into Thin-Film Transistors (TFTs) to move forwards evolution endure. Among the various semiconductors TFT technologies, oxide TFTs have garnered considerable attention due their manifold advantages, including heightened electron mobility comparison a-Si, superior transmittance, and suitability for medium large-scale applications. Recent developments engineering suggest that Augmented Reality (AR), Virtual (VR),...

Abstract We report a 20‐year‐old‐Korean woman with congenital giant pigmented nevus and angiolipoma. She was admitted our department large, dark, lesion on the right flank abdomen slowly growing mass area since birth. On biopsy, specimen taken from patch showed typical findings of compound nevus. The surgically removed. composed mature fat cells an increased vascular component. These are compatible

This work was carried out to evaluate the effects of extract from radix Astragalus membranaceus (AR) and natural product AR on SW1353 Hyman chondrocytes monosodium iodoacetate (MIA)-induced osteoarthritis (OA) model in rat. Ethanolic (ARE, 100, 200, 400 mg/kg) were orally administered once a day for 14 days after MIA injection. Administration ARE MIA-induced OA rats decreased significantly knee arthritis scoring. The histopathological analyses showed remarkably that treatment alleviated...

BACKGROUNDColumnar cell lesions (CCLs) are characterized by the presence of columnar epithelial cells lining terminal duct lobular units breast and frequently found in biopsies for microcalcifications. Their incidence relationship with other locations microcalcifications have not been established. METHODS: We reviewed 1,038 cases fibrocystic change (FCC) degrees CCLs ductal proliferative (PC) RESULTS: Among FCC cases, were 18.9%, (CCC) 12.5%, hyperplasia (CCH) 5.3% flat atypia (FEA) 1.1%....

Introduction Bipolar Disorder (BD) is a disorder in which cognitive function relatively preserved but social functioning markedly impaired. Interestingly, studies on BD show that the patients have strong desire for rewards. Hypersensitivity to rewards has not yet been sufficiently examined through experimental methods, although recent pointed out their reward hypersensitivity cause of symptoms and dysfunction. Objectives The purpose this study was investigate whether with are hypersensitive...