A5086009592- TGF-β signaling in diseases
- Prostate Cancer Treatment and Research
- Immune Cell Function and Interaction
- Cell Adhesion Molecules Research
- Trypanosoma species research and implications
- NF-κB Signaling Pathways
- Research on Leishmaniasis Studies
- Protease and Inhibitor Mechanisms
- Immune Response and Inflammation
- Cancer, Lipids, and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Estrogen and related hormone effects
- Inflammatory mediators and NSAID effects
- Wnt/β-catenin signaling in development and cancer
- Calcium signaling and nucleotide metabolism
Universidad Autónoma de Madrid
2015-2024
Consejo Superior de Investigaciones Científicas
2015-2024
Centro de Biología Molecular Severo Ochoa
2015-2024
// Konstantinos Stamatakis 1, 3 , Marta Jimenez-Martinez 1 Alba Jimenez-Segovia Isabel Chico-Calero Elisa Conde 2 Javier Galán-Martínez Julia Ruiz Alejandro Pascual Beatriz Barrocal Ricardo López-Pérez María Laura García-Bermejo Manuel Fresno Centro de Biología Molecular ''Severo Ochoa" (Consejo Superior Investigaciones Científicas-Universidad Autónoma Madrid), Universidad Madrid, Spain Instituto Ramón y Cajal Investigación Sanitaria (IRYCIS), Carretera Colmenar, Sanitario Princesa...
Understanding the signaling cascades that govern adipocyte metabolism and differentiation is necessary for development of therapies obesity. Toll-like receptors (TLRs) are key mediators in adipogenesis, but their specific role not completely understood. In this study, siRNA knockdown Tlr2 3T3-L1 cells allowed them to differentiate more efficiently into adipocytes, whereas opposite was observed Tlr4. At same time, we show TLR2 knock-out mice spontaneously developed mature-onset obesity...
The role of prostaglandin (PG) F2α has been scarcely studied in cancer. We have identified a new function for PGF2α ovarian cancer, stimulating the production Prostate Transmembrane Protein, Androgen Induced 1 (PMEPA1). show that this induction increases cell plasticity and proliferation, enhancing tumor growth through PMEPA1. Thus, PMEPA1 overexpression carcinoma cells, significantly increased proliferation rates, whereas silencing decreased proliferation. In addition, buffered TGFβ...
Chagas disease is caused by the intracellular protozoan parasite
ABSTRACT Prostaglandin (PG) F 2α has been scarcely studied in cancer. We have identified a new role for PGF ovarian cancer, stimulating the production of TGFβ and consequent induction PMEPA1. show that this increases cell plasticity proliferation, enhancing tumor growth through Thus, PMEPA1 overexpression carcinoma cells, significantly increased proliferation rates, whereas silencing decreased proliferation. In addition, buffered signaling, via reduction SMAD-dependent signaling....