A5034526151- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Genomics and Chromatin Dynamics
- Intraperitoneal and Appendiceal Malignancies
- Molecular Biology Techniques and Applications
- TGF-β signaling in diseases
- Cancer, Lipids, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Intestinal and Peritoneal Adhesions
- Cancer Immunotherapy and Biomarkers
- Prostate Cancer Treatment and Research
- Wnt/β-catenin signaling in development and cancer
- Cell Adhesion Molecules Research
- Gene expression and cancer classification
- Cancer-related Molecular Pathways
- Nanoplatforms for cancer theranostics
- Connective tissue disorders research
- Occupational and environmental lung diseases
- Uterine Myomas and Treatments
- Thyroid and Parathyroid Surgery
- Hemostasis and retained surgical items
- Cancer Genomics and Diagnostics
- Lymphatic System and Diseases
- RNA Research and Splicing
The University of Texas MD Anderson Cancer Center
2017-2021
Centro de Biología Molecular Severo Ochoa
2013-2020
Universidad Autónoma de Madrid
2013-2020
Consejo Superior de Investigaciones Científicas
2013-2020
University of Houston
2020
Abstract Peritoneal dissemination is a frequent metastatic route for cancers of the ovary and gastrointestinal tract. Tumour cells metastasize by attaching to invading through mesothelial cell ( MC ) monolayer that lines peritoneal cavity. Metastases are influenced carcinoma‐associated fibroblasts CAFs ), population derives from different sources. Hence, we investigated whether MCs , mesothelial–mesenchymal transition MMT were source during carcinomatosis affected adhesion invasion tumour...
Peritoneal adhesions (PAs) are fibrotic bands formed between bowel loops, solid organs, and the parietal peritoneum, which may appear following surgery, infection or endometriosis. They represent an important health problem with no effective treatment. Mesothelial cells (MCs) line peritoneal cavity undergo a mesothelial-to-mesenchymal transition (MMT) under pathological conditions, transforming into myofibroblasts, abundant in tissue. The aim of this study was to investigate if MCs MMT...
Abstract Peritoneal dissemination is the primary metastatic route of ovarian cancer ( OvCa ), and often accompanied by accumulation ascitic fluid. The peritoneal cavity lined mesothelial cells MCs which can be converted into carcinoma‐associated fibroblasts CAFs ) through mesothelial‐to‐mesenchymal transition MMT ). Here, we demonstrate that isolated from fluid AFMCs patients with implants also undergo promote subcutaneous tumour growth in mice. RNA sequencing revealed ‐related pathways –...
Abstract Advanced ovarian cancer usually spreads to the omentum. However, omental cell-derived molecular determinants modulating its progression have not been thoroughly characterized. Here, we show that circulating ITLN1 has prognostic significance in patients with advanced cancer. Further studies demonstrate suppresses lactotransferrin’s effect on cell invasion potential and proliferation by decreasing MMP1 expression inducing a metabolic shift metastatic cells. Additionally,...
Abstract Matrix metalloproteinases (MMPs) contribute to the breakdown of tissue structures such as basement membrane, promoting fibrosis. Here we developed an electrospun membrane biofunctionalized with a fragment laminin β1-chain modulate expression MMP2 in this context. We demonstrate that interfacing β1-fragment mesothelium peritoneal via biomaterial abrogates release active response transforming growth factor β1 and rescues integrity ex vivo mouse model Importantly, our data inhibits...
Vascular endothelial growth factor (VEGF) is up-regulated during mesothelial to mesenchymal transition (MMT) and has been associated with peritoneal membrane dysfunction in dialysis (PD) patients. It shown that normal malignant cells (MCs) express VEGF receptors (VEGFRs) co-receptors an autocrine for mesothelioma. Hence, we evaluated the expression patterns functional relevance of VEGF/VEGFRs/co-receptors axis conversion MCs induced by dialysis. Omentum-derived treated TGF-β1 plus IL-1β (in...
Uterine serous carcinoma (USC) is the most aggressive form of endometrial cancer, with poor survival rates and high recurrence risk. Therefore, purpose this study was to identify therapeutic targets that could aid in management USC. By analyzing cancer samples from The Cancer Genome Atlas (TCGA), we found Ubiquitin Carboxyl-Terminal Hydrolase L1 (UCHL1) be highly expressed USC correlate poorer overall survival. UCHL1 silencing reduced cell proliferation vitro vivo, cyclin B1 protein levels...
Chromatin accessibility data can elucidate the developmental origin of cancer cells and reveal enhancer landscape key oncogenic transcriptional regulators. We develop a computational strategy called PSIONIC (patient-specific inference networks informed by chromatin) to combine chromatin with large tumor expression model effect enhancers on programs in multiple cancers. generate new ATAC-seq profiling gynecologic basal breast cell lines apply 723 patient 96 line RNA-seq profiles from ovarian,...
The role of prostaglandin (PG) F2α has been scarcely studied in cancer. We have identified a new function for PGF2α ovarian cancer, stimulating the production Prostate Transmembrane Protein, Androgen Induced 1 (PMEPA1). show that this induction increases cell plasticity and proliferation, enhancing tumor growth through PMEPA1. Thus, PMEPA1 overexpression carcinoma cells, significantly increased proliferation rates, whereas silencing decreased proliferation. In addition, buffered TGFβ...
ABSTRACT Epigenomic data on transcription factor occupancy and chromatin accessibility can elucidate the developmental origin of cancer cells reveal enhancer landscape key oncogenic transcriptional regulators. However, in many cancers, epigenomic analyses have been limited, computational methods to infer regulatory networks tumors typically use expression alone, or rely (TF) motifs annotated promoter regions. Here, we develop a novel machine learning strategy called PSIONIC (patient-specific...
ABSTRACT Prostaglandin (PG) F 2α has been scarcely studied in cancer. We have identified a new role for PGF ovarian cancer, stimulating the production of TGFβ and consequent induction PMEPA1. show that this increases cell plasticity proliferation, enhancing tumor growth through Thus, PMEPA1 overexpression carcinoma cells, significantly increased proliferation rates, whereas silencing decreased proliferation. In addition, buffered signaling, via reduction SMAD-dependent signaling....
Epigenomic data on transcription factor occupancy and chromatin accessibility can elucidate the developmental origin of cancer cells reveal enhancer landscape key oncogenic transcriptional regulators. We develop a computational strategy called PSIONIC (patient-specific inference networks informed by chromatin) to combine cell line with large tumor expression sets model effect enhancers programs in multiple cancers. generated new ATAC-seq set profiling gynecologic basal breast lines applied...
Abstract Epigenomic data on transcription factor occupancy and chromatin accessibility can elucidate the developmental origin of cancer cells reveal enhancer landscape key oncogenic transcriptional regulators. We develop a computational strategy called PSIONIC (patient-specific inference networks informed by chromatin) to combine cell line with large tumor expression sets model effect enhancers programs in multiple cancers. generated new ATAC-seq set profiling gynecologic basal breast lines...
Abstract Uterine serous carcinoma (USC) is the most aggressive and lethal subtype of endometrial cancer with a low overall patient survival rate 18%-27%. Extra-uterine metastasis frequently found in lymph nodes omentum. The high lethality poor understanding underneath mechanisms that drives USC progression lead to an urgency develop novel therapeutic tools for treatment patients. Metastasis proven be leading cause death from immune system plays vital role this process. However, differential...
Abstract Uterine serous carcinoma (USC) is a rare but the most aggressive subtype of endometrial cancer (EC) that represents less than 10% all cases contributes to more 40% EC related deaths. The low 5-year overall survival (OS) rate and high lethality USC patients are mainly caused by extra-uterine metastasis frequently lymph nodes omentum. Deeply understanding underneath mechanism leads progression essential for development therapeutic strategies patients. communication between tumor...