A5030137276- TGF-β signaling in diseases
- Estrogen and related hormone effects
- Cancer Cells and Metastasis
- Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Bone health and treatments
- Cancer, Hypoxia, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Cell Adhesion Molecules Research
- Glaucoma and retinal disorders
- Connective Tissue Growth Factor Research
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Cancer Research and Treatments
- Liver physiology and pathology
- Dermatologic Treatments and Research
- Systemic Sclerosis and Related Diseases
- Immune Cell Function and Interaction
- Nitric Oxide and Endothelin Effects
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Retinal Diseases and Treatments
- Radiopharmaceutical Chemistry and Applications
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Intestinal and Peritoneal Adhesions
- Osteoarthritis Treatment and Mechanisms
SOM Biotech (Spain)
2010-2023
Hospital Universitario de Fuenlabrada
2022
Universidad Francisco de Vitoria
2019
Etna Biotech (Italy)
2009-2014
Universidad de Navarra
2002-2013
Cyprus Institute of Marketing
2008
Gene Therapy Laboratory
2007
Abstract CD25+ regulatory T (T reg) cells suppress the activation/proliferation of other CD4+ or CD8+ in vitro. Also, down-regulation reg enhance antitumor immune responses. In this study, we show that depletion allows host to induce both and antitumoral responses following tumor challenge. Simultaneous cells, as well adoptive transfer experiments, revealed tumor-specific which emerged absence were able reject CT26 colon cancer a MHC class II-negative tumor. The effect mediated by was...
During peritoneal dialysis (PD), mesothelial cells undergo mesothelial-to-mesenchymal transition (MMT), a process associated with peritoneal-membrane dysfunction. Because TGF-β1 can induce MMT, we evaluated the efficacy of TGF-β1-blocking peptides in modulating MMT and ameliorating damage mouse model PD. Exposure peritoneum to PD fluid induced fibrosis, angiogenesis, functional impairment, accumulation fibroblasts. In addition expressing fibroblast-specific protein-1 (FSP-1), some...
Abstract Peritoneal dissemination is a frequent metastatic route for cancers of the ovary and gastrointestinal tract. Tumour cells metastasize by attaching to invading through mesothelial cell ( MC ) monolayer that lines peritoneal cavity. Metastases are influenced carcinoma‐associated fibroblasts CAFs ), population derives from different sources. Hence, we investigated whether MCs , mesothelial–mesenchymal transition MMT were source during carcinomatosis affected adhesion invasion tumour...
Peritoneal adhesions (PAs) are fibrotic bands formed between bowel loops, solid organs, and the parietal peritoneum, which may appear following surgery, infection or endometriosis. They represent an important health problem with no effective treatment. Mesothelial cells (MCs) line peritoneal cavity undergo a mesothelial-to-mesenchymal transition (MMT) under pathological conditions, transforming into myofibroblasts, abundant in tissue. The aim of this study was to investigate if MCs MMT...
Abstract Bone is a frequent target of lung cancer metastasis, which associated with significant morbidity and dismal prognosis. To identify functionally characterize genes involved in the mechanisms osseous we developed murine model. Comparative transcriptomic analysis identified encoding signaling molecules (such as TCF4 PRKD3) cell anchorage–related proteins (MCAM SUSD5), some were basally modulated by transforming growth factor-β (TGF-β) tumor cells conditions mimicking tumor-stromal...
We investigated whether P144, a synthetic peptide from transforming growth factor-beta(1) (TGF-beta(1)) type III receptor betaglycan, exhibits cardiac antifibrotic properties.The study was carried out in one group of 10-week-old normotensive Wistar-Kyoto rats treated with vehicle (V-WKY), spontaneously hypertensive (V-SHR), and SHR P144 (P144-SHR) for 12 weeks. Two more groups untreated WKY were used to assess baseline values the parameters tested. In addition, effects on rat fibroblasts...
Nasopharyngeal carriage of Streptococcus pneumoniae is a prerequisite for invasive disease, but the majority episodes are asymptomatic and self-resolving. Interactions determining development versus disease poorly understood will influence effectiveness vaccines or therapeutics that disrupt nasal colonization.We sought to elucidate immunological mechanisms underlying noninvasive pneumococcal nasopharyngeal carriage.Pneumococcal interactions with human bronchial fibroblasts epithelial cells...
Down-regulation of CD4+CD25+ regulatory T (Treg) cell function might be beneficial to enhance the immunogenicity viral and tumor vaccines or induce breakdown immunotolerance. Although mechanism suppression used by Treg cells remains controversial, it has been postulated that TGF-beta1 mediates their immunosuppressive activity. In this study, we show P17, a short synthetic peptide inhibits TGF-beta2 developed in our laboratory, is able inhibit activity vitro vivo. studies demonstrate P17...
Abstract Melanoma progression is associated with the expression of different growth factors, cytokines, and chemokines. Because TGFβ1 a pleiotropic cytokine involved not only in physiologic processes but also cancer development, we analyzed A375 human melanoma cells, effect on monocyte chemoattractant protein-1 (MCP-1) interleukin-10 (IL-10) expression, two known factors responsible for progression. increased MCP-1 IL-10 an mediated by cross-talk between Smad, PI3K (phosphoinositide...
Abstract Transforming growth factor‐β (TGF‐β) is a cytokine with potent immunosuppressive effects and overexpressed in many tumors. Therefore, development of molecules able to inhibit TGF‐β paramount importance improve the efficacy antitumor immunotherapy. inhibitor peptides P144 P17 were combined administration adjuvant poly(I:C) agonistic anti‐CD40 antibodies, their effect on E.G7‐OVA established tumors immune response was evaluated. Tumor rejection single adjuvants enhanced from 15 70 %...
Clinical evidence suggests that the vascular abnormalities of systemic sclerosis (SSc) precede onset fibrosis, but molecular cues accounting for a possible connection SSc fibrosis have been elusive, although they searched intensively. Since we had previously shown connective tissue growth factor (CCN2), endowed with fibroblast-oriented activities, was overexpressed by endothelial cells (ECs) from patients, undertook this study to investigate its role and mechanisms in fibroblast...
Transforming Growth Factor beta (TGF-β) acts as a tumor suppressor early in carcinogenesis but turns into promoter later disease stages. In fact, TGF-β is known inducer of integrin expression by cells which contributes to cancer metastatic spread and inhibition has been shown attenuate metastasis mouse models. However, carcinoma often become refractory TGF-β-mediated growth inhibition. Therefore identifying patients that may benefit from anti-TGF-β therapy requires careful selection. We...
Summary The aim of this study was to analyse the distribution regulatory and inhibitory mothers against decapentaplegic homologue (Smad) proteins as markers active transforming growth factor (TGF)-β signalling in rheumatoid arthritis (RA) synovial tissue investigate effect TGF-β blockade development progression collagen-induced arthritis. expression Smad tissues from RA, osteoarthritic healthy controls analysed by immunohistochemistry. Arthritis induced DBA/1 mice immunization with chicken...
Hypertrophic scars are one of the most important complications in surgery due to their cosmetic and functional impairments. Previous studies tissue fibrotic disorders have shown promising results by inhibiting biological activity effect Transforming Growth Factor-beta 1 (TGF-β1). The aim current study was determine clinical inhibition TGF-β1 signaling human hypertrophic implanted nude mice topical application an inhibitor (P144®).A total 30 were 60 mice. animals divided two groups, group A...
Abstract Endoglin is a membrane glycoprotein that acts as coreceptor for transforming growth factor-β. We and others have previously suggested function of endoglin tumor suppressor in epithelial cancer. Here, we study the expression during chemical mouse skin carcinogenesis. find shedding endoglin, allowing secretion soluble form, late event associated with progression from squamous to spindle cell carcinomas. Knockdown transformed keratinocytes activates Smad2/3 signaling pathway resulting...