A5005890418- Autophagy in Disease and Therapy
- Ubiquitin and proteasome pathways
- Hippo pathway signaling and YAP/TAZ
- Signaling Pathways in Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer, Lipids, and Metabolism
- Fibroblast Growth Factor Research
- Cardiovascular Disease and Adiposity
- Adipose Tissue and Metabolism
- Cancer, Hypoxia, and Metabolism
- Cellular transport and secretion
- Viral Infections and Outbreaks Research
- Vector-Borne Animal Diseases
- Endoplasmic Reticulum Stress and Disease
- Immune cells in cancer
- Mitochondrial Function and Pathology
- Viral Infections and Vectors
Yonsei University
2020-2025
Obesity has emerged as a prominent risk factor for the development of malignant tumors. However, existing literature on role adipocytes in tumor microenvironment (TME) to elucidate correlation between obesity and cancer remains insufficient. Here, we aim investigate formation cancer-associated (CAAs) their contribution growth using mouse models harboring dysfunctional adipocytes. Specifically, employ adipocyte-specific BECN1 KO (BaKO) mice, which exhibit lipodystrophy due Our results reveal...
<title>Abstract</title> Brown adipocytes facilitate non-shivering thermogenesis, which is critical for maintaining energy balance and heat production in response to environmental stimuli. Here, we delineate the physiological biochemical role of etoposide-induced 2.4 (<italic>Ei24</italic>) adenosine triphosphate (ATP) thermogenesis brown adipocytes. We generated <italic>Ei24</italic> adipocyte-specific knockout (EiaKO) mice that exhibited adipose tissue hypertrophy, lipid accumulation,...
Becn1/Beclin-1 is a core component of the class III phosphatidylinositol 3-kinase required for autophagosome formation and vesicular trafficking. Although Becn1 has been implicated in numerous diseases such as cancer, aging, neurodegenerative disease, role white adipose tissue related metabolic remains elusive. In this study, we show that adipocyte-specific knockout mice develop severe lipodystrophy, leading to inflammation, hepatic steatosis, insulin resistance. Ablation adipocytes...
Abstract KRAS-mutant non-small cell lung cancer (NSCLC) is a major subtype that leads to many cancer-related deaths worldwide. Although numerous studies on type NSCLC have been conducted, new oncogenic or tumor suppressive genes need be detected because large proportion of patients does not respond currently used therapeutics. Here, we show the tumor-promoting function cycle-related protein, PIERCE1, in NSCLC. Mechanistically, PIERCE1 depletion inhibits growth and AKT phosphorylation (pAKT)...
Abstract Obesity has emerged as a prominent risk factor for the development of malignant tumors. However, existing literature on role adipocytes in tumor microenvironment (TME) to elucidate correlation between obesity and cancer remains insufficient. Here, we aim investigate formation cancer-associated (CAAs) their contribution growth using mouse models harboring dysfunctional adipocytes. Our results reveal that activation YAP/TAZ signaling CAAs induces adipocyte dedifferentiation TME. The...
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne human mortality rate of up to 30%, posing significant threat public health. However, the lack suitable research models has impeded development effective vaccines. In this study, we engineered transgenic mice (3xTg) using novel construct that simultaneously expresses three C-type Lectin receptors, identified as critical SFTSV entry receptors. While substantially enhanced viral binding and infection in BJAB cells, 3xTg...
Abstract Adipocytes are crucial components of the tumor microenvironment (TME) that play a prominent role in supporting growth. However, characteristics cancer-associated adipocytes (CAAs) contribute to pro-tumorigenic niche remain be fully established. Here, we used adipocyte-specific Beclin1 KO (BaKO) mice investigate maladaptive promoting progression. BECN1-deficient exhibited downregulation adipogenic markers and activation YAP/TAZ signaling, similar traits observed CAAs. Thus, generated...
<i>Becn1</i>/Beclin-1<i> </i>is a core component of the class III phosphatidylinositol 3-kinase required for autophagosome formation and vesicular trafficking. Although <i>Becn1</i> has been implicated in numerous diseases such as cancer, aging, neurodegenerative disease, role white adipose tissue related metabolic remains elusive. Here we show that adipocyte-specific knockout mice develop severe lipodystrophy, leading to inflammation, hepatic steatosis,...
<i>Becn1</i>/Beclin-1<i> </i>is a core component of the class III phosphatidylinositol 3-kinase required for autophagosome formation and vesicular trafficking. Although <i>Becn1</i> has been implicated in numerous diseases such as cancer, aging, neurodegenerative disease, role white adipose tissue related metabolic remains elusive. Here we show that adipocyte-specific knockout mice develop severe lipodystrophy, leading to inflammation, hepatic steatosis,...
<i>Becn1</i>/Beclin-1<i> </i>is a core component of the class III phosphatidylinositol 3-kinase required for autophagosome formation and vesicular trafficking. Although <i>Becn1</i> has been implicated in numerous diseases such as cancer, aging, neurodegenerative disease, role white adipose tissue related metabolic remains elusive. Here we show that adipocyte-specific knockout mice develop severe lipodystrophy, leading to inflammation, hepatic steatosis,...