A5005250476- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Immune cells in cancer
- Eosinophilic Esophagitis
- Eosinophilic Disorders and Syndromes
- Long-Term Effects of COVID-19
- Inflammasome and immune disorders
- Viral Infections and Immunology Research
- COVID-19 Clinical Research Studies
- Mast cells and histamine
- Peptidase Inhibition and Analysis
- COVID-19 and healthcare impacts
- Autoimmune and Inflammatory Disorders Research
- Venous Thromboembolism Diagnosis and Management
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiac Fibrosis and Remodeling
- SARS-CoV-2 and COVID-19 Research
- Silicon Carbide Semiconductor Technologies
Johns Hopkins University
2019-2024
Immune checkpoint inhibitors (ICIs) are an effective therapy for various cancers; however, they can induce immune-related adverse events (irAEs) as a side effect. Myocarditis is uncommon, but fatal, irAE caused after ICI treatments. Currently, the mechanism of ICI-associated myocarditis unclear. Here, we show development in A/J mice induced by anti-PD-1 monoclonal antibody (mAb) administration alone without tumor cell inoculation, immunization, or viral infection. Mice with have increased...
Myocarditis and myopericarditis may occur after COVID-19 vaccination with an incidence of two to twenty cases per 100,000 individuals, but underlying mechanisms related disease onset progression remain unclear. Here, we report a case following the first dose mRNA-1273 vaccine in young man who had history mild three months before vaccination. The patient presented chest pain, elevated troponin I level, electrocardiogram abnormality. His endomyocardial biopsy revealed diffuse CD68+ cell...
Two types of monocytes, Ly6Chi and Ly6Clo, infiltrate the heart in murine experimental autoimmune myocarditis (EAM). We discovered a role for cardiac fibroblasts facilitating monocyte-to-macrophage differentiation both Ly6Clo cells, allowing these macrophages to perform divergent functions progression. During acute phase EAM, IL-17A is highly abundant. It signals through attenuate efferocytosis monocyte-derived (MDMs) simultaneously prevents differentiation. demonstrated an inverse clinical...
Objective Arthritis associated with immune checkpoint inhibitor therapies highlights the importance of expression for joint homeostasis. We investigated role programmed death ligand (PD‐L) 1 in synovium using a collagen‐induced arthritis (CIA) mouse model. Methods blocked PD‐L1 blocking antibodies during CIA and assessed severity by clinical histologic scoring. origin synovial macrophages were flow cytometry parabiosis. used Cre‐Lox mice to ascertain protective PD‐L1–expressing arthritis....
Hypereosinophilic syndrome is a progressive disease with extensive eosinophilia that results in organ damage. Cardiac pathologies are the main reason for its high mortality rate. A better understanding of mechanisms eosinophil-mediated tissue damage would benefit therapeutic development. Here, we describe cardiac developed mouse model hypereosinophilic syndrome. These IL-5 transgenic mice exhibited decreased left ventricular function at young age which worsened age. Mechanistically,...
Abstract Immune checkpoint blockade has revolutionized the field of cancer immunotherapy; however, it been also associated with immune-related adverse events (IRAE). inhibitor (ICI)-myocarditis occurs in approximately 1% patients, a high fatality rate up to 50%. To prevent life-threatening toxicities, is imperative understand what predisposes patients ICI-myocarditis. We examined if previous cardiac injury increases an individual’s susceptibility develop demonstrated that ischemic...
Abstract Immune checkpoint inhibitor (ICI) blocking PD-1 has been approved by the Food and Drug Administration for treatment of several types cancers. However, fulminant myocarditis occurred in ICI-treated cancer patients, with low incidence but 50 percent mortality. In this study, we investigated if blockade can induce mouse mimicking ICI-associated human. We found that anti-PD-1 mAb caused development A/J mice exhibiting enlarged heart increased cardiac infiltration. infiltration, CD8+ T...
Abstract Immune related adverse events linked to severe inflammatory arthritis have been identified in 10–43% of patients receiving immune checkpoint inhibitor therapy, aCTLA-4, aPD-1 and aPD-L1, indicating the importance inhibitory pathways maintaining homeostasis synovium. We found that checkpoint, PD-L1, is primarily expressed joint compared other checkpoints. Furthermore, blocking PD-L1 during collagen induced (CIA) resulted more arthritis. Mice synovial macrophages highest expression...
Abstract Hypereosinophilic syndrome is a progressive disease with extensive eosinophilia that results in organ damage. Cardiac pathologies are the main reason for its high mortality rate. A better understanding of mechanisms eosinophil-mediated tissue damage would benefit therapeutic development. Here, we describe cardiac developed mouse model hypereosinophilic syndrome. These IL-5 transgenic mice exhibited decreased left ventricular function at young age which worsened age. Mechanistically,...
Abstract In the Covid-19 patients, vascular thrombosis is observed in heart, lung, and other organs, leading to multiorgan morbidity mortality. We obtained heart lung tissues from autopsies of patients who died or unrelated causes as a control. found that endothelial cells hearts lungs were dysfunctional state during Covid-19. Cardiac pulmonary group showed decreased level thrombomodulin, an anticoagulant, increased von Willebrand factor, procoagulant, compared non-Covid-19 Endothelial...