A5040707099- Insect and Pesticide Research
- Insect and Arachnid Ecology and Behavior
- Plant and animal studies
- Geological Modeling and Analysis
- Retinal Imaging and Analysis
- Microbial Metabolic Engineering and Bioproduction
- Geographic Information Systems Studies
- Geological formations and processes
- Geochemistry and Geologic Mapping
- Glaucoma and retinal disorders
- Digital Imaging for Blood Diseases
- Retinal Diseases and Treatments
- Bioinformatics and Genomic Networks
- Geology and Paleoclimatology Research
- Medical Image Segmentation Techniques
- Cellular Mechanics and Interactions
- Soil and Land Suitability Analysis
- Protein Structure and Dynamics
- Paleontology and Stratigraphy of Fossils
- Geological Studies and Exploration
- Methane Hydrates and Related Phenomena
- Gene Regulatory Network Analysis
- Metabolomics and Mass Spectrometry Studies
- Computational Drug Discovery Methods
- CO2 Sequestration and Geologic Interactions
Institute for Bee Research
2018-2024
Kingston University
2012-2022
Kingston University
2021
Landesanstalt für Umwelt Baden-Württemberg
2019
Technical University of Darmstadt
2005-2017
Charité - Universitätsmedizin Berlin
2003-2015
University of Freiburg
1980-2015
Heidelberg University
2011-2012
Instituto de Geociencias
2010
Humboldt-Universität zu Berlin
2003-2008
This paper presents a new supervised method for segmentation of blood vessels in retinal photographs. uses an ensemble system bagged and boosted decision trees utilizes feature vector based on the orientation analysis gradient field, morphological transformation, line strength measures, Gabor filter responses. The encodes information to handle healthy as well pathological image. is evaluated publicly available DRIVE STARE databases, frequently used this purpose also public vessel reference...
In recent years, constrained optimization – usually referred to as flux balance analysis (FBA) has become a widely applied method for the computation of stationary fluxes in large-scale metabolic networks. The striking advantage FBA compared kinetic modeling is that it basically requires only knowledge stoichiometry network. On other hand, results are large degree hypothetical because relies on plausible but hardly provable optimality principles thought govern distributions. To augment...
Epithelia grow and undergo extensive rearrangements to achieve their final size shape. Imaging the dynamics of tissue growth morphogenesis is now possible with advances in time-lapse microscopy, but a true understanding complexities limited by automated image analysis tools extract quantitative data. To overcome such limitations, we have designed new open-source toolkit called EpiTools. It provides user-friendly graphical user interfaces for accurately segmenting tracking contours cell...
Epithelial tissues can elongate in two dimensions by polarized cell intercalation, oriented division, or shape change, owing to local global actomyosin contractile forces acting the plane of tissue. In addition, epithelia undergo morphogenetic change three dimensions. We show that elongation wings and legs Drosophila involves a columnar-to-cuboidal reduces height expands width. Remodeling apical extracellular matrix Stubble protease basal MMP1/2 proteases induces wing leg elongation. Matrix...
Here, we cover a wide range of methods currently in use and recommended modern queen rearing, selection, breeding. The recommendations are meant to serve as standards for scientific practical beekeeping purposes. basic conditions different management techniques rearing described, including suitable technical equipment. As the success breeding programmes strongly depends on selective mating queens, subsection is dedicated quality control stations. Recommendations handling queens complete...
Despite enormous efforts to combat malaria the disease still afflicts up half a billion people each year of which more than one million die. Currently no approved vaccine is available and resistances antimalarials are widely spread. Hence, new antimalarial drugs urgently needed. Here, we present computational analysis metabolism Plasmodium falciparum, deadliest pathogen. We assembled compartmentalized metabolic model predicted life cycle stage specific with help flux balance approach that...
This paper introduces, and reports on the performance of, a novel combination of algorithms for automated microaneurysm (MA) detection in retinal images. The presence MAs images is pathognomonic sign Diabetic Retinopathy (DR) which one leading causes blindness amongst working age population. An extensive survey literature presented current techniques field are summarised. proposed technique first detects an initial set candidates using Gaussian Matched Filter then classifies this to reduce...
Flux-balance analysis based on linear optimization is widely used to compute metabolic fluxes in large networks and gains increasingly importance network curation structural analysis. Thus, a computational tool flexible enough realize wide variety of FBA algorithms able handle batch series flux-balance optimizations great benefit.We present FASIMU, command line oriented software for the computation flux distributions using most common algorithms, including first available implementation (i)...
Disrupted bile secretion leads to liver damage characterized by inflammation, fibrosis, eventually cirrhosis, and hepatocellular cancer. As obstructive cholestasis often progresses insidiously, markers for the diagnosis staging of disease are urgently needed. To this end, we compiled a comprehensive data set serum markers, histological parameters transcript profiles at 8 time points progression after duct ligation (BDL) in mice, aiming identifying that could be used as robust biomarkers...
Controlled mating procedures are widely accepted as a key aspect of successful breeding in almost all animal species. In honeybees, however, controlled is hard to achieve. Therefore, there have been several attempts breed honeybees using free-mated queens. such schemes, selection occurs only on the maternal path since drone sires random samples population. The success rates approaches without so far not investigated theoretical or simulation-based level.Stochastic simulation studies were...
The Apis mellifera carnica subspecies of the honeybee has long been praised for its gentleness and good honey yield before systematic breeding efforts began in early 20th century. However, introduction modern techniques genetic evaluation (best linear unbiased prediction, BLUP) a computerized data management mid 1990s, progress was slow. Here, results official value estimation BeeBreed.eu are analyzed to characterize inbreeding. From about year 2000 onward, progression accelerated resulted...
Abstract Genomic selection has increased genetic gain in several livestock species, but due to the complicated genetics and reproduction biology not yet honey bees. Recently, 2970 queens were genotyped gather a reference population. For application of genomic bees, this study analyzes accuracy bias pedigree-based breeding values for yield, three workability traits, two traits resistance against parasite Varroa destructor . value estimation, we use bee-specific model with maternal direct...
This article presents the use of digital image processing using hue, saturation, and intensity measurements as a technique for color analysis chronic wounds on skin. An adaptive spline was used to segment wound boundary in images venous leg ulcers. further approximate position The amount slough within site quantified software developed compared with grading system based visual inspection by an experienced clinician, results were deriving Kappa (K) statistic. There moderate agreement over all...
Infestation with Varroa destructor is a serious cause of bee colony (Apis mellifera) losses on global level. However, the presence untreated survivor populations in many different regions supports idea that selection for resistance can be successful. As survival difficult or impossible to measure, differences mite infestation levels and tests specific behavioral traits are used selective breeding resistance. In this paper we looked into definitions linked these brood hygiene (pin test),...
During development, multicellular organisms undergo stereotypical patterns of tissue growth in space and time. How developmental is orchestrated remains unclear, largely due to the difficulty observing quantitating this process a living organism. Drosophila histoblast nests are small clusters progenitor epithelial cells that extensive give rise adult abdominal epidermis amenable live imaging. Our quantitative analysis proliferation mechanics reveals driven by cell divisions initiated through...