A5088679247- Mass Spectrometry Techniques and Applications
- Analytical Chemistry and Chromatography
- Analytical chemistry methods development
- Metabolomics and Mass Spectrometry Studies
- Ion-surface interactions and analysis
- Advanced Chemical Sensor Technologies
- Microfluidic and Capillary Electrophoresis Applications
- Mosquito-borne diseases and control
- Indoor Air Quality and Microbial Exposure
- Insect and Arachnid Ecology and Behavior
- Olfactory and Sensory Function Studies
- Isotope Analysis in Ecology
- Advanced Proteomics Techniques and Applications
- Neurobiology and Insect Physiology Research
- Spectroscopy and Quantum Chemical Studies
- Insect and Pesticide Research
- Insect symbiosis and bacterial influences
- Forensic and Genetic Research
- Advanced Malware Detection Techniques
- Aerosol Filtration and Electrostatic Precipitation
- Enzyme Catalysis and Immobilization
- Integrated Circuits and Semiconductor Failure Analysis
- Electrohydrodynamics and Fluid Dynamics
- Energetic Materials and Combustion
- Cell Adhesion Molecules Research
University of Pittsburgh
2024-2025
Johns Hopkins University
2021-2024
University of Yamanashi
2019-2023
Takeda (Japan)
2019-2023
Loughborough University
2018-2021
Clean Energy (United States)
2019-2020
Insecticides have made great strides in reducing the global burden of vector-borne disease. Nonetheless, serious public health concerns remain because insecticide-resistant vector populations continue to spread globally. To circumvent insecticide resistance, it is essential understand all contributing mechanisms. Contact-based insecticides are absorbed through insect cuticle, which comprised mainly chitin polysaccharides, cuticular proteins, hydrocarbons, and phenolic biopolymers sclerotin...
ABSTRACT In our previous work, the sodiation of melittin, cytochrome c , and ubiquitin in a 1 mM NaOH water/methanol solution was studied by electrospray mass spectrometry. It suggested that α‐helix is more resistant to than β‐sheet. this study, enhanced green fluorescent protein (EGFP) composed β‐barrel 1% CH 3 COOH (AcOH) or Although EGFP denatured an acidic solution, it maintains near‐native structure basic solution. For AcOH protonated EGFP, [EGFP + nH − mH mNa] n+ with n = 14 36 m 0...
ABSTRACT Rationale The objective of the present study is to investigate ionization mechanisms for atmospheric pressure surface (APSI). Methods APSI carbaryl, papaverine, cocaine, morphine, and triethylamine using heated surface‐oxidized metal filaments W, Re, Pd, Mo, Ti, SUS304 were measured by mass spectrometry. Low‐volatility analytes dissolved in methanol desorbed Leidenfrost phenomenon‐assisted thermal desorption introduced filament used as an emitter. Alkylamine benzene solutions simply...
The human body secretes a complex blend of volatile organic compounds (VOCs) via the skin, breath and bodily fluids, study which can provide valuable insight into physiological metabolic state an individual. Methods to profile human-derived volatiles typically source VOCs from exhaled or skin isolated parts. To facilitate profiling whole volatilome, we have engineered sampling chamber that enables collection analysis headspace entire body. Whole were collected cohort 20 humans analyzed by...
Rationale The objective of the present study is to investigate desorption low‐volatility analytes in Leidenfrost phenomenon‐assisted thermal (LPTD). Methods LPTD was investigated for 5 μL solutions 0.03 ppm cocaine or morphine methanol (sample weight: 0.12 ng) by using heated metal surfaces (240°C) polished abrasives with grit numbers from #5000 (~3 μm) #100 (~200 μm). Results analyte signals were detected only after complete evaporation solvent and formed residues levitated on heater...
A new method utilising an <italic>in situ</italic> sampling probe coupled with mass spectrometry for rapid identification and age estimation of biofluids.
In 2007, probe electrospray ionization/mass spectrometry (PESI/MS) was developed. this technique, the needle is moved down along a vertical axis and tip of touched to sample. After capturing sample at tip, then up high voltage applied highest position generate electrospray. Due discontinuous sampling followed by generation spontaneous electrospray, sequential exhaustive takes place depending on surface activity analytes. As modified versions PESI, dipping PESI (dPESI), sheath-flow (sfPESI)...
In previous work, probe electrospray ionization/mass spectrometry (PESI/MS) and sheath-flow (sfPESI/MS) were reported for the rapid minimally invasive analysis of food. this a modified version sfPESI will be reported. The sample surface was pricked with an acupuncture needle inserted in that protruded from terminus tip by 5 mm. invasion depth into ∼1 After sampling, retracted solvent-preloaded capillary protrusion length 0.1–0.2 mm tip. A mass spectrum captured on obtained applying high...
For the thermal desorption of low-volatility compounds, rapid heating followed by instant cooling is desirable to suppress decomposition. In this work, a new method, heat pulse (HPD), was developed. A heated N2 gas (350 °C, 50 ms) directed solid sample surface, and desorbed analytes were ionized DC corona discharge mass analyzed an Orbitrap spectrometer. Because transfer from surface not very efficient, occurs at certain temperature before reaching 350 °C. short, there self-controlling...
A novel method for the rapid,<italic>in situ</italic>analysis of fresh and dried human biological materials using sfPESI mass spectrometry.