A5100332816- Cell Adhesion Molecules Research
- Cytokine Signaling Pathways and Interactions
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Ferroptosis and cancer prognosis
- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Peptidase Inhibition and Analysis
- Immune cells in cancer
- Mechanisms of cancer metastasis
- Wnt/β-catenin signaling in development and cancer
- Lymphoma Diagnosis and Treatment
- Protein Tyrosine Phosphatases
- NF-κB Signaling Pathways
- Reproductive System and Pregnancy
- Hippo pathway signaling and YAP/TAZ
- Esophageal Cancer Research and Treatment
- CAR-T cell therapy research
- Monoclonal and Polyclonal Antibodies Research
- Epigenetics and DNA Methylation
- Nitric Oxide and Endothelin Effects
- Digestive system and related health
- Inflammatory Bowel Disease
- Flavonoids in Medical Research
- Vascular anomalies and interventions
Sir Run Run Shaw Hospital
2025
Zhejiang University
2025
Peking University Cancer Hospital
2018-2024
Peking University
2018-2024
Yan'an University
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2023
Peking University International Hospital
2022-2023
Soochow University
2023
Peking Union Medical College Hospital
2022
Urbana University
2022
Tumor cell dependence on activated oncogenes is considered a therapeutic target, but protumorigenic microenvironment-mediated cellular addiction to specific oncogenic signaling molecules remains be further defined. Here, we showed that tumor-associated macrophages (TAMs) produced an abundance of C-C motif chemokine 22 (CCL22), whose expression in the tumor stroma was positively associated with level intratumoral phospho-focal adhesion kinase (pFAK Tyr397), metastasis and reduced patient...
Shear stress generated by distinct blood flow patterns modulates endothelial cell phenotype to spatially restrict atherosclerotic plaque development. Signaling through p21-activated kinase (PAK) mediates several of the deleterious effects shear stress, including enhanced NF-κB activation and proinflammatory gene expression. Whereas activates PAK in cells on a fibronectin matrix, basement membrane proteins limit shear-induced inflammation protein A-dependent pathway; however, mechanisms...
Abstract Platelet-activating factor receptor (PAFR), a G-protein–coupled receptor, has been implicated in tumorigenesis, but its contributions to metastatic progression have not investigated. Here, we show that PAFR is overexpressed non–small cell lung cancer (NSCLC) as well breast, colorectal, and gastric carcinomas. Expression of correlates closely with clinical stages, survival time, distant metastasis. In human NSCLC cells, activation the PAF/PAFR signaling axis accentuated malignant...
The prognosis for esophageal squamous cell carcinoma (ESCC) patients with lymph node metastasis (LNM) is still dismal. Elucidation of the LNM associated genomic alteration and underlying molecular mechanisms may provide clinical therapeutic strategies ESCC treatment. Joint analysis sequencing data were conducted to comprehensively survey SCNAs identify driver genes which significantly LNM. roles miR-548k in lymphangiogensis lymphatic validated both vitro vivo. tissue blood samples analyzed...
Breast cancer susceptibility gene 1 (BRCA1) has been implicated in modulating metabolism via transcriptional regulation. However, direct metabolic targets of BRCA and the underlying regulatory mechanisms are still unknown. Here, we identified several genes, including which encodes glutamate‐oxaloacetate transaminase 2 ( GOT 2), a key enzyme for aspartate biosynthesis, repressed by 1. We report that forms co‐repressor complex with ZBRK coordinately represses expression recognition element...
Reactive oxygen species (ROS) localized at the precise subcellular compartments are essential for regulating activity of signaling proteins. Furthermore, ROS master regulators tumor malignant progression that respond to a diverse set environmental stress, especially hypoxia. NADPH oxidases (NOXs) appear be activated within discrete facilitate local production. However, function NOXs in hypoxic is still unclear. In this study, we demonstrated NOX5 was greatly upregulated clinical esophageal...
Abstract The clinical therapeutic efficacy toward esophageal squamous cell carcinoma (ESCC) is undesirable, due to the lack of targeted agents. Focal adhesion kinase (FAK), a nonreceptor tyrosine involved in multiple fields tumorigenesis, recently has been indicated as promising target ESCC treatment. Here, we revealed that defactinib, specific FAK inhibitor, effectively suppressed malignancy cells. Mechanistically, defactinib dose and time‐dependently induced dissociation...
This study aims to assess the prescribing patterns and combinations of endocrine therapy medications for breast cancer across six cities in China over a six-year period. Data on outpatient prescriptions were sourced from Hospital Prescription Analysis Cooperative Project database. The analyzed trends medications, focusing number prescriptions, total costs, defined daily doses (DDDs), costs (DDC). also examined use two-drug separately premenopausal postmenopausal women. increased by 49.6%...
Six-transmembrane epithelial antigen of the prostate 1 (STEAP1), a member STEAP family, is general tumor antigen. However, no information has been available to date regarding function STEAP1 in progression endometrial carcinoma. In this study, we used vitro and vivo strategies prove that plays an important role Immunohistochemistry, immunocytochemistry, quantitative reverse transcription polymerase chain reaction (RT-qPCR), Western blot analysis were detect expression normal cells cancer...
Esophageal squamous cell carcinoma (ESCC) is one of the most common and deadly diseases. In our previous comprehensive genomics study, we found that family with sequence similarity 135 member B (FAM135B) was a novel cancer-related gene, yet its biological functions molecular mechanisms remain unclear. this demonstrate protein levels FAM135B are significantly higher in ESCC tissues than precancerous tissues, high expression correlates poorer clinical prognosis. Ectopic promoted proliferation...
Esophageal squamous cell carcinoma (ESCC) is a frequently seen esophageal tumor type in China. Activation of signaling proteins and relevant molecular mechanisms ESCC are partially explored, impairing the antitumor efficiency targeted therapy treatment. Tumor-associated macrophages (TAMs)-released C-C motif chemokine 22 (CCL22) can activate intratumoral focal adhesion kinase (FAK), thus promoting progression ESCC. Here, we demonstrated that highly secreted CCL22 by TAMs (CCL22-positive TAMs)...
TP53 gene mutations occur in more than 50% of human cancers and the vast majority these are missense mutations, which broadly DNA binding domain (DBD) (Amino acids 102–292) mainly reside six "hotspot" residues. G245C R273H point two most frequent tumors have been verified several different cancers. In previous study whole genome sequencing (WGS), we found some DBD esophageal squamous cell carcinoma (ESCC) clinical samples. We focused on high-frequent p.G245C p.R273H investigated their...
Considering the high metastatic potential of osteosarcoma, not only pro‑apoptosis, but also anti‑metastasis is important for anti‑osteosarcoma therapy. Previously, authors reported pro‑apoptotic and tumor‑inhibitory effects theabrownin (TB) on osteosarcoma cells; however, its metastasis‑related migration invasion cells remain unknown. The present study conducted RNA sequencing (RNA‑seq) xenograft zebrafish samples performed in vitro experiments, including RT‑qPCR, cell viability analysis,...
Among current novel druggable targets, protein–protein interactions (PPIs) are of considerable and growing interest. Diacylglycerol kinase α (DGKα) interacts with focal adhesion (FAK) band 4.1-ezrin-radixin-moesin (FERM) domain to induce the phosphorylation FAK Tyr397 site promotes malignant progression esophageal squamous cell carcinoma (ESCC) cells. Chrysin is a multi-functional bioactive flavonoid, possesses potential anticancer activity, whereas little known about activity exact...
Stroma surrounding the tumor cells plays crucial roles for progression. However, little is known about factors that maintain symbiosis between stroma and cells. In this study, we found transcriptional regulator-signal transducer activator of transcription 3 (Stat3) was frequently activated in cancer-associated fibroblasts (CAFs), which a potent facilitator malignancy, formed forward feedback loop with platelet-activating factor receptor (PAFR) both CAFs Importantly, PAFR/Stat3 axis connected...
Solute carrier family 38 (SLC38s) transporters play important roles in amino acid transportation and signaling transduction. However, their genetic alterations biological tumors are still largely unclear. This study aimed to elucidate the signatures of SLC38s implications esophageal squamous cell carcinoma (ESCC).Analyses on somatic mutation copy number (CNAs) SLC38A3 were performed as described. Immunohistochemistry (IHC) assay Western blot used detect protein expression level. MTS assay,...
Abstract Abnormal metabolism is regarded as an oncogenic hallmark related to tumor progression and therapeutic resistance. Present study employed multi-omics, including phosphoproteomics, untargeted metabolomics lipidomics, demonstrate that the pAKT2 Ser 128 pCCTα 315/319/323 -positive cancer-associated fibroblasts (CAFs) substantially release phosphatidylcholines (PCs), contributing resistance of focal adhesion kinase (FAK) inhibitors in esophageal squamous cell carcinoma (ESCC) treatment....
The majority of esophageal squamous dysplasia (ESD) patients progress slowly, while a subset can undergo recurrence rapidly or to invasive cancer even after proper treatment. However, the molecular mechanisms underlying these clinical observations are still largely unknown.
The present study aimed to investigate the expression of Nischarin protein in primary breast cancer (PBC), and evaluate its role tumor metastasis. Paired specimens tissues adjacent normal were surgically obtained from 60 patients with PBC at Zhejiang Cancer Hospital (Hangzhou, China). concentrations determined by an ELISA assay. Breast exhibited a significantly lower concentration (5.86±3.19 ng/ml) compared that noncancerous (9.25±3.65 ng/ml; P<0.001). Furthermore, tissue lymph node...