A5053069254- Venous Thromboembolism Diagnosis and Management
- Peripheral Artery Disease Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Angiogenesis and VEGF in Cancer
- Lipoproteins and Cardiovascular Health
- Coronary Interventions and Diagnostics
- Inflammatory mediators and NSAID effects
- Atherosclerosis and Cardiovascular Diseases
- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Atrial Fibrillation Management and Outcomes
- Smart Grid Energy Management
- Blockchain Technology Applications and Security
- Cardiac, Anesthesia and Surgical Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Peroxisome Proliferator-Activated Receptors
- Congenital heart defects research
- Cardiovascular Health and Disease Prevention
- Long-Term Effects of COVID-19
- Cardiac Fibrosis and Remodeling
- Diagnosis and Treatment of Venous Diseases
- Cell Adhesion Molecules Research
- Sensor Technology and Measurement Systems
- Infectious Aortic and Vascular Conditions
- Protease and Inhibitor Mechanisms
St. Michael's Hospital
2020-2025
Unity Health Toronto
2023-2025
University of Toronto
2018-2024
University of Cambridge
2021-2022
Tesla (United States)
2022
Background: Peripheral arterial disease (PAD) is a chronic atherosclerotic characterized by atheromatous plaque buildup within arteries of the lower limbs. It can lead to claudication, skin ulcerations, and, in severe cases, limb-threatening ischemia, requiring amputation. There are several plasma protein biomarkers that have been suggested as prognostic markers for adverse events, including major cardiovascular and limb events. However, clinical benefit ability clinically adapt these...
Peripheral arterial disease (PAD) affects more than 150 million people worldwide and is associated with high rates of lower extremity amputation, myocardial infarction, stroke death. Fatty acid binding protein 3 (FABP3) released into circulation in patients skeletal muscle injury. In this pilot study, we investigated a possible association between PAD blood levels FABP3. Blood samples were collected from clinical symptoms diagnostic findings indicative (PAD group; ankle-brachial index [ABI]...
Energy systems are transforming due to the incorporation of multiple distributed energy resources, such as renewable and battery storage systems. This transformation has triggered a need shift power distribution from low efficiency centralized model with high coordination costs decentralized system comprising smart grids. Researchers have discovered number uses for blockchain technology in sector because its structure possibility safe transactions. In order pinpoint current trends important...
Abdominal aortic aneurysm (AAA) is a progressive dilatation of the aorta that can lead to rupture. The pathophysiology disease not well characterized but known be caused by general breakdown extracellular matrix within wall. In this comprehensive literature review, all current research on proteins have been investigated for their potential prognostic capabilities in patients with AAA was included. A total 45 were found biomarkers AAA, predicting incidence rupture, growth, endoleak, and...
Objective Peripheral artery disease patients have been shown to be more susceptible thrombotic events compared non-peripheral patients. Therefore, the aim of this study was investigate coagulation profile in peripheral with chronic limb threatening ischemia, moderate claudication, and controls. Methods Chronic ischemia were matched claudication controls a 1:1:1 ratio. Each patient had their cytokines, markers thrombin generation, factors, natural anti-coagulants, fibrinolysis, endothelial...
Chronic limb-threatening ischemia (CLTI) results in devastating complications such as lower-limb amputations. In this study, a genome-wide plasma microRNAs (miRNA) sequencing was performed to identify miRNA(s) associated with CLTI. Blood samples were collected from early stage CLTI patients (ABI < 0.9) and non-PAD controls ≥ for 3 experiments: discovery phase (n = 23), confirmatory 52) validation 20). the phase, next generation (NGS) used miRNA circulating 13) patients, compared 10). Two...
Diabetic patients with peripheral arterial disease (PAD) often suffer from poor clinical outcomes such as limb-loss. Fatty acid binding protein 4 (FABP4) is mainly expressed by adipocytes and known to play a significant role in the development of atherosclerosis. In this study, we sought investigate whether FABP4 associated PAD type 2 diabetes mellitus (DM). plasma levels were studied 119 diabetic (DM-PAD) 49 without (DM-noPAD) presenting St. Michael’s Hospital between October 2017 September...
Blood-based biomarkers for abdominal aortic aneurysm (AAA) have been studied individually; however, we considered a panel of proteins to investigate AAA prognosis and its potential improve predictive accuracy.
Background: Carotid stenosis (CS) is an atherosclerotic disease of the carotid artery that can lead to devastating cardiovascular outcomes such as stroke, disability, and death. The currently available treatment for CS medical management through risk reduction, including control hypertension, diabetes, and/or hypercholesterolemia. Surgical interventions are suggested patients with symptomatic >50%, where have suffered from a carotid-related event cerebrovascular accident, or asymptomatic...
Acetylsalicylic acid (ASA), also known as aspirin, appears to be ineffective in inhibiting platelet aggregation 20–30% of patients. Light transmission aggregometry (LTA) is a gold standard function assay. In this pilot study, we used LTA personalize ASA therapy ex vivo atherosclerotic Patients were recruited who on 81 mg ASA, presenting ambulatory clinics at St. Michael’s Hospital (n = 64), with evidence disease defined clinical symptoms and diagnostic findings indicative symptomatic...
Approximately 20% of vascular patients treated with acetyl salicylic acid (i.e., aspirin) demonstrate less than expected platelet inhibition - putting them at a four-fold increased risk adverse cardiovascular events. Low-dose rivaroxaban (2.5 mg twice daily) in combination low-dose aspirin has been shown to reduce and limb events when compared alone. In this study, light transmission aggregometry was used measure arachidonic acid-induced aggregation evaluate the potential combining...
Background and Objectives: Aspirin (acetylsalicylic acid—ASA) is a first-line antiplatelet therapy provided to patients with coronary artery disease (CAD). However, it has been demonstrated that 20–30% of these are non-sensitive their ASA therapy. non-sensitivity phenomenon where low-dose (81–325 mg) does not completely inhibit arachidonic-acid-induced platelet aggregation, putting at risk adverse cardio-thrombotic events. Ticagrelor P2Y12 receptor inhibitor alternative approved reduce the...
Chronic limb-threatening ischemia (CLTI) is the most severe form of peripheral arterial disease (PAD) and affects up to 5% total PAD population. Patients with CLTI experience high rates ulcers, rest pain, other devastating morbidities such as lower limb amputations. However, despite known burden disease, microRNA (miRNA) profile patients has been insufficiently studied. Therefore, we sought conduct a genome-wide plasma miRNA sequencing study in order identify miRNAs associated CLTI. Plasma...
Aspirin (ASA) therapy is proven to be effective in preventing adverse cardiovascular events; however, up 30% of patients are non-sensitive their prescribed ASA dosage. In this pilot study, we demonstrated, for the first time, how non-sensitivity can diagnosed using Plateletworks
As the energy systems transform and power distribution moves towards smart grids comprised of multiple distributed resources (DERs) such as renewable battery storage, there is a major need to develop platforms that can decentralise due shortcomings centralised system high coordination costs low efficiency. Since its inception in 2008, blockchain technology has found application every field from finance healthcare decentralised nature potential for secure transactions, researchers have also...