A5019716413- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Gender Studies in Language
- Animal Genetics and Reproduction
- Sexual Differentiation and Disorders
- RNA modifications and cancer
- Sperm and Testicular Function
- Immune Cell Function and Interaction
- Genomics and Chromatin Dynamics
- T-cell and B-cell Immunology
- Epigenetics and DNA Methylation
- Hormonal and reproductive studies
Linköping University Hospital
2020-2025
Linköping University
2023-2025
The Francis Crick Institute
2025
Technical errors have resulted in the false discovery of DNA modification N 6 -methyladenine mammals.
As females are mosaic for X-inactivation, direct determination of X-linked allelic expression in bulk tissues is typically unfeasible. Using that non-mosaic X-inactivation (nmXCI) has proven a powerful and natural genetic system profiling humans. By combining allele-resolution data one previously reported two newly identified nmXCI females, we directly determined status 380 genes across 30 normal tissues, including 198 which XCI the first time. Our findings represent substantial advance our...
As females are mosaic for X-inactivation, direct determination of X-linked allelic expression in bulk tissues is typically unfeasible. Using that non-mosaic X-inactivation (nmXCI) has proven a powerful and natural genetic system profiling humans. By combining allele-resolution data one previously reported two newly identified nmXCI females, we directly determined status 380 genes across 30 normal tissues, including 198 which XCI the first time. Our findings represent substantial advance our...
The mammalian Y chromosome is essential for male fertility, but which genes regulate spermatogenesis unresolved. We addressed this by generating 13 Y-deletant mouse models. In Eif2s3y , Uty and Zfy2 deletants, was impaired. found that regulates spermatogonial proliferation, revealed a role in promoting meiotic sex pairing, uncovered unexpected effects of on the somatic testis transcriptome. remaining single Y-gene appeared unperturbed, transcription still altered. Multigene deletions,...
The mammalian Y chromosome is essential for male fertility, but how individual genes regulate spermatogenesis poorly understood. To resolve this question, we generate a deletion series of the mouse chromosome, creating thirteen Y-deletant models and conducting exhaustive reproductive phenotyping. Eight genes, including several that are deeply conserved exhibit testis-specific expression, dispensable spermatogenesis. For others, uncover novel functions, role Uty in establishment...
Abstract As females are mosaic for X-inactivation, direct determination of X-linked allelic expression in bulk tissues is typically unfeasible. Using that non-mosaic X-inactivation (nmXCI) has proven a powerful and natural genetic system profiling humans. By combining allele-resolution data one previously reported two newly identified nmXCI females, we directly determined status 380 genes across 30 normal tissues, including 198 which XCI the first time. Our findings represent substantial...
Abstract Females exhibit a more robust immune response to both self-antigens and non-self-antigens than males, resulting in higher prevalence of autoimmune diseases but effective responses against infection. Increased expression X-linked genes female T cells is thought underlie this enhanced response. Here we isolate thymocytes from pediatric thymi healthy males (46, XY), females XX), with completely skewed X-chromosome inactivation XX, cXCI) Turner syndrome (45, X0). Using whole exome...