A5047109861- Animal Genetics and Reproduction
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Sperm and Testicular Function
The Francis Crick Institute
2025
The mammalian Y chromosome is essential for male fertility, but which genes regulate spermatogenesis unresolved. We addressed this by generating 13 Y-deletant mouse models. In Eif2s3y , Uty and Zfy2 deletants, was impaired. found that regulates spermatogonial proliferation, revealed a role in promoting meiotic sex pairing, uncovered unexpected effects of on the somatic testis transcriptome. remaining single Y-gene appeared unperturbed, transcription still altered. Multigene deletions,...
The mammalian Y chromosome is essential for male fertility, but how individual genes regulate spermatogenesis poorly understood. To resolve this question, we generate a deletion series of the mouse chromosome, creating thirteen Y-deletant models and conducting exhaustive reproductive phenotyping. Eight genes, including several that are deeply conserved exhibit testis-specific expression, dispensable spermatogenesis. For others, uncover novel functions, role Uty in establishment...