A5040251106- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Gender Studies in Language
- Epigenetics and DNA Methylation
- Sexual Differentiation and Disorders
- Animal Genetics and Reproduction
- Immune Cell Function and Interaction
- Microtubule and mitosis dynamics
- T-cell and B-cell Immunology
- RNA modifications and cancer
- Sperm and Testicular Function
- Acute Myeloid Leukemia Research
- Hormonal and reproductive studies
- Cancer Cells and Metastasis
- Genomics and Chromatin Dynamics
- T-cell and Retrovirus Studies
- Cancer-related Molecular Pathways
- Acute Lymphoblastic Leukemia research
Linköping University
2024-2025
The Francis Crick Institute
2025
Linköping University Hospital
2020-2025
Institute of Molecular Biology
2015
Technical errors have resulted in the false discovery of DNA modification N 6 -methyladenine mammals.
// Verena Rohnalter 1 , Katrin Roth 2 Florian Finkernagel Till Adhikary Julia Obert Kristina Dorzweiler Maike Bensberg Sabine Müller-Brüsselbach Rolf Müller Institute of Molecular Biology and Tumor Research (IMT), Center for Immunology, Philipps University, Marburg 35043, Germany Cell Imaging Core Facility, Correspondence to: Müller, e-mail: rmueller@imt.uni-marburg.de Keywords: chemoresistance, giant cancer cells, polyploidy, senescence-associated secretory phenotype (SASP),...
Pediatric T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy resulting from overproduction of immature T-cells in the thymus and typified by widespread alterations DNA methylation. As survival rates for relapsed T-ALL remain dismal (10 to 25%), development targeted therapies prevent relapse key improving prognosis. Whereas mutations demethylating enzyme TET2 are frequent adult malignancies, rare. Here, we analyzed RNA-sequencing data 321 primary T-ALLs, 20 cell lines, 25...
As females are mosaic for X-inactivation, direct determination of X-linked allelic expression in bulk tissues is typically unfeasible. Using that non-mosaic X-inactivation (nmXCI) has proven a powerful and natural genetic system profiling humans. By combining allele-resolution data one previously reported two newly identified nmXCI females, we directly determined status 380 genes across 30 normal tissues, including 198 which XCI the first time. Our findings represent substantial advance our...
As females are mosaic for X-inactivation, direct determination of X-linked allelic expression in bulk tissues is typically unfeasible. Using that non-mosaic X-inactivation (nmXCI) has proven a powerful and natural genetic system profiling humans. By combining allele-resolution data one previously reported two newly identified nmXCI females, we directly determined status 380 genes across 30 normal tissues, including 198 which XCI the first time. Our findings represent substantial advance our...
The mammalian Y chromosome is essential for male fertility, but which genes regulate spermatogenesis unresolved. We addressed this by generating 13 Y-deletant mouse models. In Eif2s3y , Uty and Zfy2 deletants, was impaired. found that regulates spermatogonial proliferation, revealed a role in promoting meiotic sex pairing, uncovered unexpected effects of on the somatic testis transcriptome. remaining single Y-gene appeared unperturbed, transcription still altered. Multigene deletions,...
The mammalian Y chromosome is essential for male fertility, but how individual genes regulate spermatogenesis poorly understood. To resolve this question, we generate a deletion series of the mouse chromosome, creating thirteen Y-deletant models and conducting exhaustive reproductive phenotyping. Eight genes, including several that are deeply conserved exhibit testis-specific expression, dispensable spermatogenesis. For others, uncover novel functions, role Uty in establishment...
Abstract As females are mosaic for X-inactivation, direct determination of X-linked allelic expression in bulk tissues is typically unfeasible. Using that non-mosaic X-inactivation (nmXCI) has proven a powerful and natural genetic system profiling humans. By combining allele-resolution data one previously reported two newly identified nmXCI females, we directly determined status 380 genes across 30 normal tissues, including 198 which XCI the first time. Our findings represent substantial...
Abstract Females exhibit a more robust immune response to both self-antigens and non-self-antigens than males, resulting in higher prevalence of autoimmune diseases but effective responses against infection. Increased expression X-linked genes female T cells is thought underlie this enhanced response. Here we isolate thymocytes from pediatric thymi healthy males (46, XY), females XX), with completely skewed X-chromosome inactivation XX, cXCI) Turner syndrome (45, X0). Using whole exome...