A5010246396- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Animal Genetics and Reproduction
- Sperm and Testicular Function
- Circadian rhythm and melatonin
- Genetics, Aging, and Longevity in Model Organisms
The Francis Crick Institute
2021-2025
University College London
2019
The mammalian Y chromosome is essential for male fertility, but which genes regulate spermatogenesis unresolved. We addressed this by generating 13 Y-deletant mouse models. In Eif2s3y , Uty and Zfy2 deletants, was impaired. found that regulates spermatogonial proliferation, revealed a role in promoting meiotic sex pairing, uncovered unexpected effects of on the somatic testis transcriptome. remaining single Y-gene appeared unperturbed, transcription still altered. Multigene deletions,...
Ageing populations pose one of the main public health crises our time. Reprogramming gene expression by altering activities sequence-specific transcription factors (TFs) can ameliorate deleterious effects age. Here we explore how a circuit TFs coordinates pro-longevity transcriptional outcomes, which reveals multi-tissue and multi-species role for an entire protein family: E-twenty-six (ETS) TFs. In Drosophila, reduced insulin/IGF signalling (IIS) extends lifespan coordinating activation...
The mammalian Y chromosome is essential for male fertility, but how individual genes regulate spermatogenesis poorly understood. To resolve this question, we generate a deletion series of the mouse chromosome, creating thirteen Y-deletant models and conducting exhaustive reproductive phenotyping. Eight genes, including several that are deeply conserved exhibit testis-specific expression, dispensable spermatogenesis. For others, uncover novel functions, role Uty in establishment...