A5015391145- Foot and Ankle Surgery
- Tendon Structure and Treatment
- Orthopedic Surgery and Rehabilitation
- Sports injuries and prevention
- Shoulder Injury and Treatment
- Orthopedic Infections and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Lower Extremity Biomechanics and Pathologies
- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Shoulder and Clavicle Injuries
- Musculoskeletal synovial abnormalities and treatments
- Cell Adhesion Molecules Research
- Wound Healing and Treatments
- Elbow and Forearm Trauma Treatment
- Nerve Injury and Rehabilitation
- Sarcoma Diagnosis and Treatment
- Spine and Intervertebral Disc Pathology
- Caveolin-1 and cellular processes
- Power System Optimization and Stability
- Immunotherapy and Immune Responses
- Management of metastatic bone disease
- Advanced materials and composites
- Glioma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
University of California, Irvine
2016-2024
Palomar Health
2024
Medical University of South Carolina
2024
University of Washington
2023
Johns Hopkins University
2023
Synaptics (United States)
2017
Rex Medical (United States)
2017
Arthrex (United States)
2017
Ames Research Center
2017
UConn Health
2017
Hydroxy fatty acids are critical lipid mediators involved in various pathophysiologic functions. We cloned and identified GPR31, a plasma membrane orphan G protein-coupled receptor that displays high affinity for the human 12-lipoxygenase-derived product 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (HETE). Thus, GPR31 is named 12-(S)-HETE (12-HETER) this study. The 12-HETER demonstrated binding 12-(S)-[(3)H]HETE (K(d) = 4.8 ± 0.12 nm). Also, efficiently selectively stimulated GTPγS...
Background: Limited incision techniques for acute Achilles tendon ruptures have been developed in recent years to improve recovery and reduce postoperative complications compared with traditional open repair. The purpose of this retrospective cohort study was analyze the clinical outcomes between treated using a percutaneous repair system (PARS [Arthrex, Inc, Naples, FL]) versus evaluate overall operatively ruptures. Methods: Between 2005 2014, 270 consecutive cases were reviewed (101 PARS,...
We previously reported on the metal ion concentrations of cobalt, chromium, and titanium that were found in serum patients three years after they had undergone primary total hip arthroplasty as compared with control who did not have an implant. This study is a concise update levels cohort these ten time implantation. Of original seventy-five subjects, available for forty (53%). Ten (hybrid group) received hybrid replacement consisted modular cobalt-alloy femoral stem head been inserted...
Jones fractures commonly occur in professional athletes and operative treatment remains the standard of care this patient population. In our clinical experience, an aggressive postoperative rehabilitation protocol for National Football League (NFL) players with average return to play (RTP) between 8 10 weeks can have successful outcomes few complications. The purpose study was quantify RTP rate complications, including nonunion, refracture, reoperation among a cohort NFL operatively treated...
Background: Preoperative computer navigation and patient-specific instrumentation have had promising results in total knee arthroplasty a previous cadaveric ankle (TAA) study. Potential benefits of guides include improved implant alignment decreased surgical time. The purpose this retrospective case series was to evaluate the accuracy, reproducibility, limitations TAA tibia talar placement radiographic using preoperative computed tomography (CT) scan–derived clinical setting. Methods:...
Infolding and retraction of an avulsed deltoid complex after ankle fracture can be a source persistent increased medial clear space, malreduction, postoperative pain instability. The purpose this descriptive case series was to analyze the preliminary outcomes acute superficial avulsion repair during fixation in cohort National Football League (NFL) players. We found that there is often complete off proximal aspect malleolus high-energy fractures athletes.Between 2004 2014, cases 14 NFL...
Abstract Purpose: Abegrin is a monoclonal antibody to human integrin αVβ3, cell adhesion molecule highly expressed on actively angiogenic endothelium and glioblastoma multiforme tumor cells. The purpose of this study was evaluate the efficacy novel 90Y-Abegrin radioimmunotherapeutic agent in murine xenograft models with noninvasive vivo molecular imaging modalities. Experimental Design: A s.c. U87MG model used determine maximum tolerated dose (MTD), biodistribution, response, 90Y-Abegrin....
The present study evaluated the early clinical outcomes, radiographic parameters, and survivorship of first second-generation INBONE intramedullary-fixation total ankle arthroplasties.Fifty-nine primary arthroplasties utilizing I or II implants were performed in fifty-nine patients (thirty-one men twenty-eight women; mean age, 57.2 years) from 2008 to 2012. AOFAS (American Orthopaedic Foot & Ankle Society) ankle-hindfoot score VAS (visual analog scale) pain recorded preoperatively at time...
Sphingosine-1-phosphate (S1P) regulates a wide array of biological functions. However, the role S1P signaling in tumorigenesis remains to be elucidated. In this study, we show that receptor subtype 3 (S1P3) is markedly up-regulated subset lung adenocarcinoma cells compared normal epithelial cells. Specific knockdown S1P3 receptors inhibits proliferation and anchorage-independent growth Mechanistically, demonstrate increases epidermal factor (EGFR) expression via Rho kinase (ROCK) pathway...
The use of digital radiography and templating software in total knee arthroplasty (TKA) continues to become more prevalent as the number procedures performed increases every year. Template-directed instrumentation (TDI) is a novel approach surgical planning that combines with limited intraoperative instruments. purpose this study was evaluate financial implications radiographic outcomes using TDI direct during primary TKA. Over 1-year period, 82 consecutive TKAs were retrospectively...
The use of digital radiography and templating software continues to become more prevalent in orthopedics as the number total hip arthroplasty (THA) knee (TKA) procedures increases every year. purpose this study was evaluate effect training level on accuracy for primary THA TKA. Digital radiographs 97 patients undergoing (49 cases) TKA (48 were retrospectively templated using OrthoView planning (OrthoView LLC, Jacksonville, Florida). Anteroposterior lateral digitally compared with actual size...
Objective: This two-part study tested the hypotheses that use of a new cooling device, purported to extract heat from body core through palm hand, would (a) attenuate temperature rise during submaximal exercise in heat, thereby suppressing exercise-associated metabolic changes, and (b) facilitate higher sustained workload, thus shortening completion time time-trial performance test. Methods: In Study 1, 8 male triathletes (age 27.9 ± 2.0 yrs, mass 77.2 3.1 kg, [Formula: see text]Peak 59.0...
The diagnosis and treatment of symptomatic chondral lesions in young active middle-aged patients continues to be a challenging issue. Surgeons must differentiate between incidental from pathology that is responsible for the patient's pain. A thorough history, physical examination, imaging work up necessary often results exclusion verified on arthroscopy. Treatment glenohumeral depends several factors including age, occupation, comorbidities, activity level, degree injury concomitant shoulder...