Recent studies have shown that thyroglobulin (Tg) concentration is a useful tumor marker in follow-up of differentiated thyroid cancer (DTC) patients after thyroidectomy and subsequent radioiodine (I-131) therapy. However, its role controversial total or near-total before the first I-131 ablative treatment. So, we used thyroid-stimulating hormone (TSH) levels to normalize predictive values Tg for DTC.The study was retrospective analysis. A 244 with DTC who had undergone therapy were...

Studies suggested a potential value of preablative stimulated thyroglobulin (ps-Tg) on predicting the recurrent and persistent diseases differentiated thyroid cancer, whereas its correlations with therapeutic response remain uncertain.To establish correlation between ps-Tg proposed in 2015 American Thyroid Association guidelines, calculate cutoff threshold for poor response.Patients who underwent total thyroidectomy radioactive iodine therapy university hospital participated this...

Postoperative preablative stimulated thyroglobulin (ps-Tg) has been evaluated in predicting prognosis and success of ablation regarding differentiated thyroid cancer (DTC); however, its relationship with recurrence risk radioiodine decision-making remains uncertain, especially Chinese DTC patients. We aimed to evaluate the association between ps-Tg stratification DTC, provide incremental values for postoperative assessment management.Seven hundred seven patients were included; low-risk (L; n...

// Na Zhou 1 , Congmin Liu 2 Helei Hou Chuantao Zhang Dong Guanqun Wang 3 Kewei Jingjuan Zhu Hongying Lv Tianjun Li and Xiaochun Department of Oncology, The Affiliated Hospital Qingdao University, Qingdao, China Municipal Hospital, Pathology, Correspondence to: Zhang, email: Keywords : spindle cell carcinoma; Apatinib; VEGFR; targeted therapy Received July 04, 2016 Accepted October 03, Published 11, Abstract Spindle carcinoma the breast is a rare subtype metaplastic carcinoma, no effective...

The optimal preablative level of thyrotropin (TSH) for patients with differentiated thyroid cancer (DTC) to achieve better response after I ablation remains unknown. objective this study was assess whether a higher TSH above 30 μIU/mL is associated therapy in low- intermediate-risk DTC and explore the potential factors that may impact their responses.A total 204 consecutive non-high-risk were retrospectively reviewed. Serum thyroglobulin (Tg) levels measured right before treatment thyroxine...

Abstract Our study aimed to explore the efficacy and safety of anlotinib–toripalimab combination therapy as a second-line treatment for advanced relapsed gastric or gastroesophageal junction carcinoma (GC/GEJC). In this single arm, single-center extension clinical trial, patients with GC/GEJC received toripalimab (240 mg, intravenously over 60 minutes, once every 2 weeks) plus anlotinib (12 mg/day, orally, weeks on 1 week off, 3 therapy. There were 29 who achieved partial response, ORR was...

Intratypic variations of HPV-18 are known to differ in the persistence infection, frequency carcinogenesis and progression precursor lesions advanced cervical cancer. This study was designed analyze sequence isolates order discover novel variants evaluate among infected women southwest China. Cervical biopsies from 56 HPV-18-positive with neoplasia were assayed by PCR amplification sequencing all eight genes (E1, E2, E4, E5, E6, E7, L1, L2) genome. The most frequently observed variation a C...

Abstract Objective: Preablative stimulated thyroglobulin (ps-Tg) has the potential to be used in identifying distant metastatic differentiated thyroid carcinoma (DM-DTC), but its single level can affected by remnant tissue and thyrotropin (TSH). The objective of this retrospective study was evaluate value serial ps-Tg measurements DM-DTC specifically. Methods: A total 317 DTC patients with ps-Tg, TSH anti-Tg antibody were divided into M1 (n=72) M0 (n=245) according presence metastasis (DM)...

Camrelizumab, a programmed death 1 (PD-1) inhibiting antibody, has demonstrated efficacy in various malignancies and received approval multiple countries. Despite its therapeutic benefits, camrelizumab is associated with unique spectrum of immune-related adverse effects (irAEs), predominantly reactive cutaneous capillary endothelial proliferation (RCCEP). However, visceral manifestations such proliferations, particularly hepatic cavernous hemangiomas, have not been extensively documented....

The Alphapapillomavirus 9 (α-9 HPV) is a member of the genus and Papillomaviridae family. These viruses are almost all carcinogenic HPV, which closely related to 75% invasive cervical cancer worldwide, has high prevalence in Sichuan. function mainly realized by its E6 oncoprotein.Cell samples were collected scraped for HPV detecting typing. HPV-16, HPV-31, HPV-33, HPV-52, HPV-58 5 α-9 subtype positive selected, their gene was sequenced analyzed. selection sites genes estimated PAML 4.8...

Objective To investigate the value of pre-ablation stimulated Tg in predicting distant metastasis papillary thyroid cancer (PTC).Methods The study included 231 patients with PTC who had undergone total thyroidectomy and subsequent 131I therapy.Patients were divided into two groups as M1(38 cases,15 males,23 females,average age (43.9 ± 16.3) y) M0(193 cases,60 males,133 (42.4 11.4) according to presence absence metastases,respectively.T-test x2 test used evaluate statistical differences...

Preablative stimulated thyroglobulin (ps-Tg) is somewhat nonspecific when used as a predictive marker for distant metastases (DM) from differentiated thyroid carcinoma because of the impact residual tissue postsurgery. The aim this study was to explore potential value serial ps-Tg measurements and assess clinical these in context remnants.A total 370 consecutive patients with ps-Tg, thyrotropin (TSH), anti-Tg antibody before radioactive iodine ablation were included study. Patients divided...

Distant metastasis of rare malignant struma ovarii (MSO) has been reported for cases associated with papillary thyroid cancer but few follicular cancer. A 38-yr-old woman that was initially diagnosed as "benign" presented pulmonary and coughing 17 yr later. The lungs lesions were confirmed to be by biopsy. Rereview the initial surgical ovary specimens condition MSO patient treated total thyroidectomy, which showed no malignancy, followed (131)I (iodine-131) treatments. Dramatic reduction...

Nucleophosmin (NPM) and human epidermal growth factor receptor-2 (Her-2) are abnormally expressed in various types of malignant tumors, including gastric cancer, have been closely associated with cancer chemoresistance. However, their interaction roles oxaliplatin resistance not fully understood. Therefore, the present study aimed to elucidate relationship between NPM Her-2 cell lines clinical samples, further investigated role oxaliplatin. Western blotting reverse transcription-quantitative...

Abstract Background Human papillomavirus type 39 associated with genital intraepithelial neoplasia and invasive cancers, has a high prevalence in Southwest China. HPV E6, E7 are two main oncoproteins, closely relate to the function of immortalization, cell transformation, carcinogenesis. L1 is major capsid protein, can reflect replication status virus cells progression cervical lesions. The purpose this study reveal genetic polymorphisms HPV39 based on gene southwest Methods Cell samples...

To investigate the relationship between dynamic variation of pre-ablation stimulated thyroglobulin(sTg)and distant metastasis in patietns with differentiated thyroid cancer(DTC).DTC patients after total or near thyroidectomy were divided into two groups as M1 group(n=38)and M0 group(n=130)according to presence metastases not. Clinical data including sTg and corresponding thyrotropin(TSH)values dynamically measured. The TSH collected at first time defined Tg1 TSH1,while Tg2 TSH2 last time....

To investigate the time to disappearance of thyroglobulin antibodies (TgAb) and its influencing factors in papillary thyroid carcinoma (PTC) patients with positive TgAb after radioiodine ((131)I) ablation.We retrospectively analyzed clinical data 64 PTC who had undergone a total thyroidectomy subsequent (131)I therapy. Patients were divided into two groups according presence concurrent Hashimoto thyroiditis (HD). TgAb1 (TgAb levels determined before therapy) above normal thresholds all...

Chengdu is one of the earliest pilot cities for urban-rural basic medical insurance integration in China. This study aimed to analyze influencing factors hospitalization costs senile cataract a tertiary hospital by robust method, especially considering influence type. A total 1310 discharged patients from January 2020 June 2021 who were mainly diagnosed with cataracts selected as research subjects. Kruskal-Wallis H test and Spearman correlation analysis are used conduct univariate...

Cervical cancer is the second most malignant tumor among women of childbearing age, almost all cervical cancers are associated with high-risk (HR) human papillomavirus (HPV) persistent infection. HPV infection and cell immortalization does not always cause cancer, but they increase risk can lead to formation carcinogenesis in cooperation other tumorigenic factors, HR-HPV E6 oncoprotein mainly factors. binds highly conserved sequence "LXXLL" E6AP form a heterodimer, which recruits induces...

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