A5049751911- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pulmonary Hypertension Research and Treatments
- Angiogenesis and VEGF in Cancer
- Blood Coagulation and Thrombosis Mechanisms
- Neonatal Respiratory Health Research
- Cell Adhesion Molecules Research
- SARS-CoV-2 and COVID-19 Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Diabetes and associated disorders
- Hemophilia Treatment and Research
- Cardiac Valve Diseases and Treatments
- Platelet Disorders and Treatments
- Aortic Disease and Treatment Approaches
- COVID-19 Clinical Research Studies
- Pluripotent Stem Cells Research
- Immune cells in cancer
- Vitamin K Research Studies
- Congenital heart defects research
- Blood groups and transfusion
- Lymphatic System and Diseases
- Blood disorders and treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Venous Thromboembolism Diagnosis and Management
- interferon and immune responses
- Zebrafish Biomedical Research Applications
Inserm
2014-2025
Hôpital Européen Georges-Pompidou
2018-2025
Université Paris-Saclay
2023-2025
Bicêtre Hospital
2023-2025
Assistance Publique – Hôpitaux de Paris
2013-2025
Université Paris Cité
2013-2024
Hôpital Européen
2014-2024
Sorbonne Paris Cité
2013-2023
Innovations Thérapeutiques en Hémostase
2020
Délégation Paris 5
2014-2019
ABSTRACT Valve interstitial cells (VICs) play a critical role in aortic valve calcification and angiogenic processes associated with calcific stenosis (CAVS). Within the same valve, VICs from differently calcified regions can exhibit diverse phenotypic functional properties. We hypothesised that isolated noncalcified (NC‐VICs) (C‐VICs) areas of human valves possess distinct characteristics. In this study, we C‐VICs NC‐VICs 23 obtained after replacement due to CAVS. Both VIC types exhibited...
The study's aim was to analyze the capacity of human valve interstitial cells (VICs) participate in aortic angiogenesis. Approach and Results: VICs were isolated from valves obtained after surgery for calcific disease normal unsuitable grafting (control VICs). We examined VIC vitro vivo potential differentiate endothelial perivascular lineages. paracrine effect also on colony-forming cells. A pathological (VIC
Summary Pulmonary vasodilators and prostacyclin therapy in particular, have markedly improved the outcome of patients with pulmonary hypertension (PH). Endothelial dysfunction is a key feature PH, we previously reported that treprostinil increases number proliferative potential endothelial colony forming cells (ECFC) isolated from PH patients’ blood. In present study, objective was to determine how contributes proangiogenic functions ECFC. We examined effect on ECFC obtained cord blood terms...
Les thrombopénies constitutionnelles sont des affections rares d'origine génétique, caractérisées par une diminution du nombre plaquettes sanguines. Ces pathologies fréquemment diagnostiquées chez les enfants et peuvent être associées à saignements atteintes syndromiques. L'identification de nouvelles causes génétiques a été facilitée techniques séquençage haut débit. Au cours la dernière décennie, ont vu le gènes impliqués augmenter significativement. anomalies touchent principalement...
Abstract Therapeutic management of acquired von Willebrand syndrome (AVWS) can be challenging, particularly in cases AVWS associated with monoclonal IgM such as Waldenström macroglobulinemia (WM) where several therapeutic options may ineffective. Here, we describe the case an 88-year-old patient who developed during follow-up for WM. The presence a severe bleeding symptomatology not controlled by therapies (plasma-derived factor, plasmapheresis) led us to introduce supplementation...
This work confirms the previously reported impairment in functional response to exercise training of patients with COPD compared SHS. Moreover, it shows for first time that pericyte coverage skeletal capillaries is drastically reduced SHS during training-induced angiogenesis. Finally, provides experimental evidence circulating factors are involved impaired COPD.
diagnosis and monitoring of iron deficiency associated thrombocytopenia: about two cases