Green synthesis, characterization and evaluation of nanoscale zinc sulfide (ZnS) by precipitation chemical method. The nanoparticles were prepared method using heterocyclic polyvinyl alcohol, PVA as a sensitizer. compounds system ZnS nanoparticles, PVA, EG used anti-bacterial corrosion towards sulfate-reducing bacteria (SRB) anti-corrosion for carbon steel substrate in sulfuric acid hydrogen bacterial corrosive environment chemical, analytical, electrochemical techniques. Effect adding...

Abstract 6‐Amino‐3‐methyl‐4‐(4‐nitrophenyl)‐2,4‐dihydropyrano[2,3‐ c ]pyrazole‐5‐carbonitrile ( 1 ) was used as a precursor for preparation of some novel 3,7‐dimethyl‐4‐(4‐nitrophenyl)‐2,4‐dihydropyrazolo[4′,3′:5,6]pyrano[2,3‐ d ]pyrimidine derivatives 3 – 6 , and their corresponding N 2 ‐ C 5 S ‐acyclic nucleosides 7 8 . Furthermore, the 5‐amino‐1‐[3,7‐dimethyl‐4‐(4‐nitrophenyl)‐2,4‐dihydropyrazolo[4′,3′:5,6]pyrano[2,3‐ ]pyrimidin‐5‐yl]‐1 H ‐pyrazole 10 16 were described. Some prepared...

Five new sulfur containing heterocyclic derivatives of sulfanyl pyridazine type compounds (1-5) were synthesized, characterized by FT-IR and 1 H NMR, evaluated as corrosion inhibitors for carbon steel in 1.0 M HCl at various concentration temperatures.Five different analytical techniques used this study, namely, gravimetrical, gasometrical, atomic absorption spectroscopy, AAS, thermometric, acidimetric techniques.The inhibition efficiency increases with increasing inhibitor but decreases...

This study aims to synthesize a novel series of nicotinonitriles incorporating pyrazole, oxadiazole, isoindoline, thiadiazole, and thiazolidinone moieties (compounds 4–11). The synthesis utilizes 2‐((3‐cyano‐4‐(4‐fluorophenyl)‐6‐(naphthalen‐2‐yl)pyridin‐2‐yloxy)acetohydrazide (3) as key starting material enhance potential anticancer activity. molecular structures compounds 4–11 were elucidated using various spectroscopic techniques elemental analysis. synthesized screened for cytotoxic...

Abstract 6‐Amino‐5‐imino‐pyrazolo[4′,3′:5,6]pyrano[2,3‐ d ]pyrimidine derivative 4 and pyrazolo‐[4′,3′:5,6]pyrano[2,3‐ ]pyrimidin‐5‐ylhydrazine 5 were prepared starting from 6‐amino‐3‐methyl‐4‐( p ‐nitrophenyl)‐2,4‐dihydropyrano[2,3‐ c ]pyrazole‐5‐carbonitrile 1 . The synthesis structure characterization of 9,11‐dihydropyrazolo[4′,3′:5,6]pyrano[3,2‐ e ][1,2,4]triazolo[4,3‐ derivatives 7 9 their isomerization to ] [1,2,4]triazolo[1,5‐ 6 8, respectively, under different suitable reaction...

Abstract A novel β -enaminonitrile of 1-(6-p-tolyl-pyridazin-3-yl)-pyrazole derivative 2 was formed using (6-p-tolyl-pyridazin-3-yl)-hydrazine ( 1 ) and 2-ethoxymethylenemalononitrile. The β-enaminonitrile in turn used as a precursor for the preparation pyrazoles 4 , 6 ), pyrazolo[3, 4-d]-pyrimidines 3 7–12 pyrazolo[4, 3-e][1,2,4]triazolo[4,3-c]pyrimidine 13 ). Also, N- S-acyclic nucleosides 14 15 were prepared. Some prepared products showed potent antimicrobial activity.

Some novel indeno[2,1-b]thiophenes, indeno[1′,2′:4,5]thieno[2,3-d][1,2,3]triazines, indeno[1′,2′:4,5]thieno[2,3-d]pyrimidines, indeno[1′,2′:4,5]thieno[2,3-d][1,3]thiazolo[3,2-a]pyrimidines, and indeno[1′,2′:4,5]thieno[2,3-d][1,2,4]triazolo[4,3-a]pyrimidines 2–16 were prepared starting with 2-aminoindeno[2,1-b]thiophene-3-carboxylic acid amide ( 1 ). Furthermore, the antimicrobial evaluation of products showed that many them revealed promising activity.

: In terms of fused heterocyclic compounds, pyrrolopyrimidines, and their substituted analogs are among the most extensively explored scaffolds. Based on location nitrogen atom in pyrrole ring, pyrrolopyrimidines have different isomers. This study deals only with pyrrolo[2,3-d]pyrimidine isomer. Several techniques represented discussed this review for producing derivatives. The first one is cyclization pyrimidine ring through reaction β-enaminonitrile, β-enaminoester or β-enaminoamide...

Anticancer activity, a novel series of 6-((1 H -1,2,3-triazol-4-yl)methyl)-6 -indolo[2,3- b ]quinoxalines (22–29) were designed and synthesized via the copper( i )-catalyzed azide–alkyne cycloaddition (CuAAC) reactions.

Pyridine and fused pyridines derivatives are interesting compounds with diverse chemical properties pharmacological activities. Herein, the synthesis antiviral evaluation of some new described.

Compounds 2 and 9 were formed using 3-(4-chloro-phenyl)-1-pyridin-2-yl propenone ( 1 ) malononitrile or ethyl cyanoacetate, respectively. The pyridine derivative was in turn used as a precursor for the preparation of some pyridopyrimidine fused derivatives 3–8 On other hand, thienopyridine 11 12 Nitrozation compound afforded pyridothienotriazine 13 Some prepared products showed potent antimicrobial activity.

Abstract A series of novel substituted pyrimidinones and fused (compounds 3 – 18 ) were synthesized starting with oxiranylmethanone 2 . The in vitro cytotoxicity against a human breast adenocarcinoma (MCF‐7) cell line was investigated most the tested compounds showed potent cytotoxic activity MCF‐7 comparable to commonly used anticancer drug cisplatin. Treatment cells increasing doses (2, 5, 10, 20 µg/mL) revealed that superoxide dismutase level hydrogen peroxide significantly increased,...

5‐Amino‐1‐ p ‐tolyl‐1 H ‐pyrazole‐4‐carbonitrile ( 1 ) was used for the preparation of some novel pyrazoles and pyrazolo[3,4‐ d ]pyrimidines 2 – 10 . Moreover, cytotoxicity in vitro anticancer activities prepared compounds were also assessed against MCF‐7 breast cancer, HepG2 liver A549 lung carcinoma cell lines, along with investigation effect synthesized on expression urokinase plasminogen activator (uPA). The tested exhibited remarkable cytotoxic activity cells. Among compounds, 9...

Novel β-enaminonitrile of 1-(6-phenyl-pyridazin-3-yl)-pyrazole derivative 2 was formed using (6-phenyl-pyridazin-3-yl)-hydrazine (1) and 2-ethoxymethylene-malononitrile. The in turn used as precursors for the preparation 1-(6-phenyl-pyridazin-3-yl)-pyrazoles (3, 9, 11), 1-(6-phenyl -pyridazin-3-yl)-pyrazolo[3,4-d]pyrimidines (4, 5, 6, 7, 8, 13, 14, 15, 16) some their corresponding N-acyclic nucleosides (17, 18). All synthesized compounds were tested antimicrobial evaluation, 3, 17, 18 showed...

3-Methyl-1-phenyl-1,5-dihydro-pyrazolo [3,4-d]pyrimidine-4-thione was prepared and used as a key compound for the preparation of some S-acyclic nucleosides pyrazolo [3,4d]pyrimidine-thiones.Furthermore, corrosion inhibitions compounds towards carbon steel by 1.0 M hydrochloric acid were evaluated chemical electrochemical methods.The effect inhibitors concentrations temperatures studied.The inhibition efficiency increased with decreased temperature.Addition inhibitor molecules to aggressive...