A5040686717- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Reactions of Organic Compounds
- Synthesis of heterocyclic compounds
- Synthesis of Organic Compounds
- Synthesis and Biological Evaluation
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Click Chemistry and Applications
- Organic Chemistry Cycloaddition Reactions
- Multicomponent Synthesis of Heterocycles
- Quinazolinone synthesis and applications
- Synthesis and Catalytic Reactions
- Synthesis and Reactivity of Heterocycles
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Chemical Synthesis and Reactions
- Chemical Reactions and Mechanisms
- Chemical Synthesis and Analysis
- Bioactive Compounds and Antitumor Agents
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Photochromic and Fluorescence Chemistry
- Oxidative Organic Chemistry Reactions
- Sulfur-Based Synthesis Techniques
- Fluorine in Organic Chemistry
- Porphyrin and Phthalocyanine Chemistry
National Research Centre
2009-2024
Shaqra University
2014
National Research Institute
1998
Abstract 6‐Amino‐3‐methyl‐4‐(4‐nitrophenyl)‐2,4‐dihydropyrano[2,3‐ c ]pyrazole‐5‐carbonitrile ( 1 ) was used as a precursor for preparation of some novel 3,7‐dimethyl‐4‐(4‐nitrophenyl)‐2,4‐dihydropyrazolo[4′,3′:5,6]pyrano[2,3‐ d ]pyrimidine derivatives 3 – 6 , and their corresponding N 2 ‐ C 5 S ‐acyclic nucleosides 7 8 . Furthermore, the 5‐amino‐1‐[3,7‐dimethyl‐4‐(4‐nitrophenyl)‐2,4‐dihydropyrazolo[4′,3′:5,6]pyrano[2,3‐ ]pyrimidin‐5‐yl]‐1 H ‐pyrazole 10 16 were described. Some prepared...
Abstract 6‐Amino‐5‐imino‐pyrazolo[4′,3′:5,6]pyrano[2,3‐ d ]pyrimidine derivative 4 and pyrazolo‐[4′,3′:5,6]pyrano[2,3‐ ]pyrimidin‐5‐ylhydrazine 5 were prepared starting from 6‐amino‐3‐methyl‐4‐( p ‐nitrophenyl)‐2,4‐dihydropyrano[2,3‐ c ]pyrazole‐5‐carbonitrile 1 . The synthesis structure characterization of 9,11‐dihydropyrazolo[4′,3′:5,6]pyrano[3,2‐ e ][1,2,4]triazolo[4,3‐ derivatives 7 9 their isomerization to ] [1,2,4]triazolo[1,5‐ 6 8, respectively, under different suitable reaction...
Click chemistry has been utilised for the preparation of new tris(triazolyl)triazines containing aliphatic and polar side chains through coupling 2,4,6-triethynyl-[1,3,5]triazines, which possess free terminal alkyne moieties with substituted aromatic azides. The cytotoxic activity in vitro anticancer potential newly synthesised compounds have evaluated against seven human cancer cell lines including liver HepG2, breast MCF-7, lung A549, acute myeloid leukemia HL-60, colon HCT116, prostate...
There is an urgent need to develop and synthesize new anti-influenza drugs with activity against different strains, resistance mutations, suitability for various populations. Herein, we tested in vitro vivo the antiviral of 1,2,3-triazole glycosides incorporating benzimidazole, benzooxazole, or benzotriazole cores synthesized by using a click approach. The Cu-catalyzation strategy consisted 1,3-dipolar cycloaddition azidoalkyl derivative respective heterocyclic glycosyl acetylenes five six...
Several derivatives containing the thieno[2,3-d]pyrimidine system were prepared starting from 2-amino-4,5-dihydronaphtho[2,1-b]thiophene-1-carbonitrile (1). In particular, synthesis and structure characterization of 8,9-dihydronaphtho- [1′,2′:4,5]thieno[3,2-e][1,2,4]triazolo[4,3-c]pyrimidine 13–16 their isomerization to 8,9-dihydronaphtho[1′,2′:4,5]thieno[3,2-e][1,2,4]-triazolo[1,5-c]pyrimidine 17–20 under different suitable reaction conditions reported verified with X-ray analysis....
A series of new substituted triazolo[4,5-d]pyrimidine derivatives linked to thienopyrimidine ring system were prepared as a hybrid heterocyclic systems, possible nucleobases analogs, starting from the key carboxamide derivative 2 and its azide precursor via heterocyclization reactions their structures characterized. Glycosylation triazolopyrimidine was performed afforded, regioselctively, corresponding thienopyrimidine-triazolopyrimidine N1-glycosides thioglycoside analogues in good yields....
A series of triazolo-pyridazinone derivatives were prepared through the standard click reactions 4,6-diphenyl-2-(prop-2-yn-1-yl)pyridazin-3(2H)-one 1, possessing a free terminal alkyne group with selection substituted aryl azides 2-9. The cytotoxicity and in vitro anticancer investigation new compounds conducted against four different human tumor cell lines, including breast adenocarcinoma MCF-7, hepatocellular carcinoma HepG2, lung cancer A549 colon HCT116 lines. results showed that exerted...
Article The Behaviour of Ethyl 1-acetyl-4-aryl-5-cyano-3-methyI-1,4-dihydropyrano[2,3-c]pyrazol-6-ylimidoformate Towards Nucleophiles was published on February 1, 2004 in the journal Heterocyclic Communications (volume 10, issue 1).
Novel β-enaminonitrile of 1-(6-phenyl-pyridazin-3-yl)-pyrazole derivative 2 was formed using (6-phenyl-pyridazin-3-yl)-hydrazine (1) and 2-ethoxymethylene-malononitrile. The in turn used as precursors for the preparation 1-(6-phenyl-pyridazin-3-yl)-pyrazoles (3, 9, 11), 1-(6-phenyl -pyridazin-3-yl)-pyrazolo[3,4-d]pyrimidines (4, 5, 6, 7, 8, 13, 14, 15, 16) some their corresponding N-acyclic nucleosides (17, 18). All synthesized compounds were tested antimicrobial evaluation, 3, 17, 18 showed...
Abstract magnified image Reaction of 6‐amino‐2‐methylthiouracil and 6‐amino‐1,3‐dimethyluracil with equimoler amounts cyclic ketones or 1,3‐diketones the appropriate aromatic aldehydes yielded regioselectivity a series polycyclic pyrimido[4,5‐ b ]quinoline pyrido[2,3‐ d ]pyrimidine derivatives in good yields.
Some new indeno[1′,2′ :4,5]thieno[2,3-d]pyrimidines were prepared from the reaction of 2-aminoindeno[2,1-b]thiophene-3-carbonitrile ( 1 ) with different reagents. Also, some :4,5]thieno[3,2-e]tetrazolo[1,5-c]pyrimidines and :4,5]thieno[3,2-e][1,2,4]triazolo[4,3-c]pyrimidines their isomeric [1,2,4]triazolo[1,5-c]pyrimidines prepared. The antimicrobial evaluation products showed that many them revealed promising activity.
The reaction of compounds 1, 2, 3, 4, or 13 with 2-chloroethyl methyl ether 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide, afforded some acyclic and cyclic nucleosides thieno[2,3-d]pyrimidine derivatives. Furthermore, C-nucleosides 24 25 were prepared from the 20, 21 26, 27 D-glucose. antimicrobial evaluation products showed promising activity.
New 1,2,3-triazole glycosides and 1,2,4-thioglycosides incorporating a substituted pyrimidinedione ring system were synthesized via click dipolar cycloaddition heterocyclization of hydrazine-1-carbodithioate derivatives, respectively. The sugar hydrazine derivatives linked aminodimethyluracil also prepared. In addition, the oxadiazoline with acyclic moieties to as nucleoside analogs synthesized. antiviral activity compounds against avian influenza H5N1 virus was investigated 18, 13 19 showed...
Abstract Hydrazones 12a–c and ketazines 13a–c were prepared by the reaction of ketones 11a–c with hydrazine hydrate depending on temperature time. Some ketone (aryl)hydrazone derivatives 14a,c,e reacted thionyl chloride to afford chlorothiadiazoline 15a–c . Surprisingly, chlorine atom in latter compounds was found undergo smooth nucleophilic substitution, boiling these absolute ethanol gave corresponding ethoxythiadiazoline 16a–c The structure 16b confirmed single crystal X‐ray...
AbstractA series of 3″,5″-diaryl-3″H-dispiropyran/thiopyran[4,2′-chroman-3′,2″-[1,3,4-thiadiazol]-4′-ones 5a-n were synthesized from the reaction trispiro[tetrahydropyran(tetrahydrothiopyran)-4,5′-2H-chromeno-[3,4-e][1,3,4]oxadithiin-2′,3″-chroman-2″4′″-tetrahydropyran-(tetrahydrothiopyran)]-4″-ones 3a,b with nitrilimines (generated in situ via triethylamine dehydrohalogenation corresponding hydrazonoyl chlorides). A single crystal diffraction compound 5a adds support for established...
α-Chloro β-oxo sulfenyl chlorides 2 were reduced by iodide ions to the corresponding α-oxo thioketones 3 which dimerized in situ a hetero-[4 + 2] cycloaddition give 1,3,4- oxadithiin derivatives 4. The 3, situ, cyclized also with 2,3-dimethyl-1,3- butadiene adducts 5 and only case of oxo thioketone intermediate 3d two products 4d 5d obtained. Also, 3a,c, underwent furan 6a,c together dimers 4a,c. When this reaction was carried out presence diethyl acetylenedicarboxylate or chalcone derivative 8, 4a-d