There is an increasing interest in the synthesis of metal nanoparticles (NPs) from bulk metals using pulsed laser ablation liquids (PLAL), as it offers easy and simple route. In this work, zeolite NPs (molecular sieve 4A) were successfully synthesized by PLAL technique, characterized X‐ray diffraction, scanning electron microscopy, Fourier transform infrared spectroscopy, transmission field emission high‐resolution microscopy. Data obtained confirm formation crystalline phase zeolite. The...

Pyrazolo[1,5-a]pyrimidines 5a–c, 9a–c and 13a–i were synthesized for evaluation of their in vitro antimicrobial properties against some microorganisms immunomodulatory activity. The biological activities pyrazolo[1,5-a]pyrimidines showed that the (5c, 9a, 9c, 13a, 13c, 13d, 13e 13h) displayed promising activities. Studying silico predicted physicochemical, pharmacokinetic, ADMET drug-likeness confirmed most compounds (i) within range set by Lipinski’s rule five, (ii) show higher...

An efficient and facile approach for the synthesis of 5-aminopyrazoles from ketene S,N-acetal hydrazine hydrate via catalytic reaction under solvent free condition has been described. V2O5/SiO2 as a heterogeneous catalyst was prepared characterized using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) scanning electron microscope (SEM). KEY WORDS: One-pot synthesis, 5-Amino-1H-pyrazole, Hydrazine hydrate, Vanadium oxide, Silica Bull. Chem. Soc. Ethiop. 2019, 33(1),...

TCS/ZnCl2 is presented as a new catalyst for achieving the Michael addition adduct 5a-g by reaction of phenyl pyrazolone 4 donor and arylidene derivatives 3a-g acceptor. The one-pot multi-component same fragments' scaffolds aldehydes 1a-g, malononitrile (2), with gives pyrano[2,3-c]pyrazole 6a-g final products. prepared compounds undergo docking validation COVID-19 protease inhibitors are compared hydroxychloroquine reference drug. KEY WORDS: Pyranopyrazole, reactions, catalyst, COVID-19,...

Copper-Vit B3 MOF was successfully prepared by efficient and eco hydrothermal method. The characterized as a tetragonal crystal copper-MOF nanoparticles FTIR, SEM, TEM, EDX XRD. were used an effective, inexpensive low-toxic catalyst in the one-pot synthesis of some new benzoxanthenone derivatives. As example 4-(9,9-dimethyl-11-oxo-8,10,11,12-tetrahydro-9H-benzo[a]xanthen-12-yl)phenyl benzoate (4h) synthesized high yield 92%. catalyst's role is activating nucleophilic attack increasing...

Series of new thiosemicarbazones was prepared and molecular studied as inhibitors HCV 4WTG polymerase. Thus, the thiosemicarbazone derivatives (3a–k) were synthesized by two different ways, from reacting thiosemicarbazides with aldehydes one-pot three component reaction using ZnCl2/SiO2 a catalyst under solvent free conditions. Molecular docking analysis products predicted that 3c, 3g, 3k most promised highly for polymerase in comparison Sofosbuvir drug.

A competent new one‐pot synthesis for tetrahydrobenzo[f]chromeno[3,2‐c]tetrazolo[1,5‐a]azepines through the catalytic of related xanthenes. β‐naphthol, dimedone, aromatic aldehydes were stirred under solvent free condition in presence tetrachlorosilane (TCS), then azidochlorosilane (which prepared situ from sodium azide and TCS acetonitrile as solvent) was added reaction at 50‐60 oC. molecular docking synthesized compounds carried out order to investigate their binding pattern with...

SERIES of dihydropyrimidine(thi)one derivatives were prepared, in …..good yields at room temperature by using a modified Biginelli reaction. The products obtained through one-pot three-component coupling β-diketones, aldehydes and urea (or thiourea) the presence catalytic amount tetrachlorosilane (TCS). effect catalyst type, molar ratios reactants solvent type also investigated; best results when TCS was employed as CH

In this article, we presented a novel, efficient and facile approach for using strontium titanate supported catalyst in organic synthesis. Bis tetrakis of coumarin, indole xanthene derivatives can effortlessly have prepared V 2 O 5 /perovskite nanoparticles (NPs) under solvent‐free condition. was identified Fourier transform infrared spectroscopy (FTIR), X‐ray diffraction (XRD) scanning electron microscope with energy dispersive (SEM/EDAX). Calculated crystal size from the intense XRD peaks...

A simple and efficient catalytic synthesis of new 1H-pyrazole-1-carbothioamide derivatives through a one-pot reaction hydrazine hydrate, arylidene malononitrile isothiocyanates in the presence HAp/ZnCl2 nano-flakes at 60-70°C has been described. The protocol's main advantages include high yields products, wide range substrates, procedure, short time. Molecular docking studies designed compounds were accomplished as COX-2 inhibitors showed that 3d, 3e, 3h, 3n give promising results compared...

Copper-based oxide glass-ceramic was successfully synthesized through the single-step melt annealing technique. Synthesized glass-ceramics characterized using X-ray diffraction (XRD) and scanning electron microscopy (SEM) supported with energy dispersive (EDX) mapping. Pyrazolo[1,5-a]pyrimidines 5a-f were via reaction of 5-amino-1H-pyrazole-4-carboxamide (1) enaminones 2a-f in presence catalyst powder under solvent-free condition. The molecular docking study demonstrated that COVID-19 main...

An efficient, expeditious catalytic route for the synthesis of ethyl 6‐amino‐5‐cyano‐2‐methyl‐4‐aryl‐4 H ‐pyran‐3‐carboxylates 2 was achieved via a three‐component, one‐pot reaction malononitrile, acetoacetate, and various aromatic aldehydes in water as solvent at room temperature. The key advantages are excellent yield, time, inexpensive catalyst. Also, cyclization 4 ‐pyrans to corresponding ‐pyrano[2,3‐ d ]pyrimidines 3 using silica sulfuric acid presence acetic anhydride described. Some...

Synthesis of 2-substituted benzothiazole derivatives using ZnCl2 nano-flakes supported on nano-hydroxyapatite as a catalyst. Has been achieved by one-pot reaction 1 mole aromatic heterocyclic aldehydes with 2-aminothiophenol under solvent – free condition. The adopted has many characteristics: fast, efficacious, eco-friendly and short time ZnCl2/HAp catalyst was synthesized identified X-ray diffraction, Scanning Electron Microscopy, Fourier transforms infrared. obtained results explained the...

Abstract In reaction to the expanding predominance of diabetes mellitus, curcumin nanoparticles stacked on carboxymethyl cellulose (CMC) composite were effectively synthesized, characterized, and examined utilizing UV/Vis FTIR spectroscopy combined with transmission electron microscopy (TEM). The bioactivity (Cur), (CMC), (CUR-CMC) was tried through atomic docking approval as an α-amylase α-glucosidase inhibitor. conclusion illustrated that curcumin-supported CMC is more potent than CUR...