A5055515301- Synthesis and biological activity
- Click Chemistry and Applications
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Biological Evaluation
- Antifungal resistance and susceptibility
- Cholinesterase and Neurodegenerative Diseases
- Estrogen and related hormone effects
- Nigella sativa pharmacological applications
- Nephrotoxicity and Medicinal Plants
- Liver Disease Diagnosis and Treatment
- HIV/AIDS drug development and treatment
- Drug-Induced Hepatotoxicity and Protection
- Carbohydrate Chemistry and Synthesis
- Synthesis and Reactions of Organic Compounds
- Fungal Infections and Studies
- Garlic and Onion Studies
- Quinazolinone synthesis and applications
- Pregnancy and Medication Impact
- Advanced Breast Cancer Therapies
Egyptian Atomic Energy Authority
2018-2024
Abstract A series of coumarin‐6‐sulfonamides derivatives bearing a thiazole and thiadiazole scaffold were synthesized, their chemical structures inferred from correct spectral microanalytical data. All the newly synthesized compounds have been screened for ability to prevent proliferation Mucor racemosus , Syncephalastrum racemosum in vitro. The most potent chosen determine MIC value compared standard antifungal agent (Posaconazole). Remarkably, an excellent anti‐mucormycosis was obtained by...
A new series of 1,3,4-thiadiazoles was synthesized by the reaction methyl 2-(4-hydroxy-3-methoxybenzylidene) hydrazine-1-carbodithioate (2) with selected derivatives hydrazonoyl halide grinding method at room temperature. The chemical structures newly were resolved from correct spectral and microanalytical data. Moreover, all compounds screened for their antimicrobial activities using Escherichia coli, Pseudomonas aeruginosa, Proteus vulgaris, Bacillus subtilis, Staphylococcus aureus,...
Aromatase inhibitors (AIs) show promising features as drugs to treat estrogen-responsive breast cancer they block aromatase activity, the key enzyme in estrogen synthesis. The current AIs approved by Food and Drug Administration for treatment present severe adverse effects. For these reasons, it is important develop of new that are more specific sensitive. In this paper, we report synthesis characterization nonsteroidal containing triazoles moieties hormone-dependent post-menopausal women. A...
In this study, a new synthetic 1,2,3-triazole-containing disulfone compound was derived from dapsone. Its chemical structure confirmed using microchemical and analytical data, it tested for its in vitro antibacterial potential. Six different pathogenic bacteria were selected. MICs values ATP levels determined. Further, toxicity performance measured MicroTox Analyzer. addition, molecular docking study performed against two vital enzymes: DNA gyrase Dihydropteroate synthase. The results of...
Novel 1,3,4-thiadiazole derivatives were synthesized through the reaction of methyl 2-(4-hydroxy-3-methoxybenzylidene) hydrazine-1-carbodithioate and appropriate hydrazonoyl halides in presence a few drops diisopropylethylamine. The chemical structure newly fabricated compounds was inferred from their microanalytical spectral data. With increase microbial diseases, fungi remain devastating threat to human health because resistance microorganisms antifungal drugs. COVID-19-associated...
In an attempt to improve the performance of biologically active anticancer agents, a novel series 1-substituent-4-(3,4-dimethoxyphenyl)-1H-1,2,3-triazole hybrids 10–16 were designed and efficiently synthesized via copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reactions 4-ethynyl-1,2-dimethoxybenzene 1 with substituted-azides 2–8. The structure new clicked 1,2,3-triazole was confirmed on basis their elemental analysis spectral data. Moreover, cytotoxicity in vitro activities newly...
Liver is the key organ (detoxifier) that gets injured by reactive oxygen species (ROS) which deplete body's stores of anti-oxidants. ROS present in all chronic liver diseases leading to oxidative stress. Consumption foods high anti-oxidants replenishes and supplies body with important break down lowering inflammatory responses preventing damage. In this work, clove honey, are known be rich extracts were evaluated for their potential breakdown ROS, Reactive nitrogen (RNS) lower stress rats....
Abstract (3‐(4‐Fluorophenyl)oxyran‐2‐yl)(naphthalene‐2‐yl)methanone 2 was prepared from the reaction of 3‐(4‐fluorophenyl)‐1‐(naphthalen‐2‐yl)prop‐2‐en‐1‐one ( 1 ) with hydrogen peroxide and reacted different nucleophiles such as hydrazine hydrate, phenyl hydrazine, thiosemicarbazide to give 4‐hydroxy‐1 H ‐pyrazole derivatives 3a,b‐4 . Also, compound treated hydroxylamine hydrochloride substituted 2,3‐dihydroisoxazole 5 Similarly, carbon disulfide, isothiocyanate, isocyanate corresponding...