A5061251061- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Parasites and Host Interactions
- Galectins and Cancer Biology
- Plant Pathogenic Bacteria Studies
- Mycobacterium research and diagnosis
- Bacterial biofilms and quorum sensing
- Force Microscopy Techniques and Applications
- Heme Oxygenase-1 and Carbon Monoxide
- Viral Infections and Immunology Research
- Genomics and Phylogenetic Studies
- Legionella and Acanthamoeba research
- Extracellular vesicles in disease
Universidad de Panamá
2020-2025
Universidad de Granada
2020-2024
Extracellular vesicles (EVs) are small lipid released by either any prokaryotic or eukaryotic cell, both, with a biological role in cell-to-cell communication. In this work, we characterize the proteomes and nanomechanical properties of EVs tissue-culture cell-derived trypomastigotes (mammalian infective stage; (TCT)) epimastigotes (insect (E)) Trypanosoma cruzi, etiologic agent Chagas disease. each stage were isolated differential centrifugation analyzed using liquid chromatography tandem...
We report the whole genome sequence of Mycolicibacterium parafortuitum strain Panama NTM1, isolated from cattle feces at a dairy farm in (8°08'18.1″N and 80°54'00.1″W). DNA was extracted pure culture this isolate whole-genome sequencing performed using Illumina MiSeqⓇ platform. After de novo assembly, has total size 5.92 Mbp, GC content 68.4 %, 5545 annotated genes. The raw read files have been deposited NCBI database under BioProject number PRJNA1113557.
Background Trypanosoma cruzi , the hemoparasite that causes Chagas disease, is divided into six Discrete Typing Units or DTUs: TcI-TcVI plus Tcbat. This genetic diversity based on ecobiological and clinical characteristics associated with particular populations of parasite. The main objective this study was identification DTUs in patients chronic chagasic infections from a mountainous rural community eastern region Panama. Methods A total 106 were tested for disease three serological tests...
Acanthamoeba is a genus of free-living amoebae widely distributed in nature, associated with the development encephalitis and keratitis. Despite fact that it common to find genotype T5 environmental samples, only few cases have been clinical humans. The wide distribution Acanthamoeba, characteristic being amphizoic severity disease motivate researchers focus on isolation these organisms, but also demonstrating direct indirect factors could indicate possible pathogenic potential. Here, we...
Trans-sialidases (TS) are important constitutive macromolecules of the secretome present on surface Trypanosoma cruzi (T. cruzi) that play a central role as virulence factor in Chagas disease. These enzymes have been related to infectivity, escape from immune surveillance and pathogenesis exhibited by this protozoan parasite. In work, atomic force microscopy (AFM)-based single molecule-force spectroscopy is implemented suitable technique for detection location functional TS extracellular...
Background Chagas disease, once restricted mainly to the Americas, disease has become a global health problem due migration from endemic non-endemic areas. In regions, transmission is limited vertical infected mothers newborns or through blood and organ donations. A major challenge in management of lies diagnosis chronic cases, as blood-borne parasites are often absent antibodies persist for life, complicating evaluation treatment. Methodology main findings This study investigates whether...