A5046713019- Cancer Immunotherapy and Biomarkers
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Sarcoma Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Musculoskeletal pain and rehabilitation
- Colorectal Cancer Treatments and Studies
- Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Cleft Lip and Palate Research
- Craniofacial Disorders and Treatments
- Immune Cell Function and Interaction
- Colorectal and Anal Carcinomas
- Scoliosis diagnosis and treatment
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Opioid Use Disorder Treatment
- Diversity and Career in Medicine
- Nasal Surgery and Airway Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Spinal Cord Injury Research
- Medical Imaging and Analysis
- Management of metastatic bone disease
- Muscle activation and electromyography studies
Johns Hopkins Medicine
2014-2024
Johns Hopkins University
2014-2024
Thomas Jefferson University Hospital
2022-2024
Rothman Orthopaedics
2022-2024
Boston University
2024
Stryker (United States)
2022-2023
Medtronic (Ireland)
2022-2023
Rothman Institute
2022-2023
Thomas Jefferson University
2022-2023
Stryker (United Kingdom)
2023
Background Current therapy for osteosarcoma pulmonary metastases (PMs) is ineffective. The mechanisms that prevent successful immunotherapy in are incompletely understood. We investigated the tumor microenvironment of metastatic with goal harnessing immune system as a therapeutic strategy. Methods 66 tissue specimens were analyzed by immunohistochemistry (IHC) and markers digitally quantified. Tumor-infiltrating lymphocytes (TILs) from 25 profiled functional cytometry. Comparative...
Meeting abstracts We examined the immune microenvironment of primary colorectal cancer (CRC) using immunohistochemistry, laser capture microdissection/qRT-PCR, flow cytometry and functional analysis tumor infiltrating lymphocytes. A subset CRC displayed high infiltration with activated CD8+
Approximately 10% of patients with mismatch repair-proficient (MMRp) colorectal cancer showed clinical benefit to anti-PD-1 monotherapy (NCT01876511). We sought identify biomarkers that delineate immunoreactive and explore new combinatorial immunotherapy strategies can impact MMRp cancer.
Clinical trials with immune checkpoint inhibition in sarcomas have demonstrated minimal response. Here, we interrogated the tumor microenvironment (TME) of two contrasting soft-tissue (STS), rhabdomyosarcomas and undifferentiated pleomorphic (UPS), differing genetic underpinnings responses to understand mechanisms that lead response.Utilizing fresh formalin-fixed, paraffin-embedded tissue from patients diagnosed UPS rhabdomyosarcomas, dissected TME by using IHC, flow cytometry, comparative...
Significance In this study, we report the finding that a subpopulation of hypoxic cancer cells expressed genes involved in mitochondrial function, sustained oxidative metabolism, and were fully tumorigenic. These findings indicate that, whereas Warburg effect contributes to metabolism growing cells, tumorigenicity does not exclusively depend on it is diminished by continued respiration under hypoxia.
Several predictive biomarkers are currently approved or under investigation for the selection of patients checkpoint blockade. Tumor PD-L1 expression is used stratification non-small cell lung (NSCLC) patients, with tumor mutational burden (TMB) also being explored promising results, and mismatch-repair deficiency site-agnostic disease. While tumors high expression, TMB, mismatch repair respond well to blockade, lower burdens, proficiency much less frequently.We studied two unexpected...
Mismatch-repair deficiency in solid tumors predicts their response to PD-1 blockade. Based on this principle, pembrolizumab is approved as standard of care for patients with unresectable or metastatic microsatellite instability-high (MSI-H) cancer. Despite success, a large majority colorectal cancer are not MSI-H and do benefit from checkpoint blockade treatment. Predictive biomarkers develop personalized medicines guide clinical trials needed these patients. We, therefore, asked whether...
Background: Autologous cartilage grafts have a low risk of infection and extrusion in cleft rhinoplasty. However, harvesting autologous involves donor-site morbidity increased time under anesthesia. Irradiated homologous costal may be an effective alternative. Methods: A retrospective study was performed on patients with history lip who underwent rhinoplasty for nasal deformity at Johns Hopkins Hospital from 2009 to 2018. Patients were excluded if their did not involve graft. Results: One...
Highlights•RIC haploBMT with post-transplant cyclophosphamide use was investigated for high-risk solid tumors.•This platform is a safe and feasible treatment pediatric young adult patients.•Treatment provides excellent rates of engraftment low incidences NRM acute/chronic GVHD.•Treatment new, nontolerant immune system relapse therapies.AbstractHigh-risk, recurrent, or refractory tumors in pediatric, adolescent, (AYA) patients have an extremely poor prognosis despite current intensive...
Abstract Background The utilization of social media is growing among academic and private practice plastic surgeons. Objectives aim this study was to determine training backgrounds board certification medical professionals through the use surgery-related hashtags on a single platform, Instagram. Methods Instagram queried with 15 surgery–related hashtags. Only top 50 posts each hashtag were analyzed at time point international accounts excluded. Data collected included account owner, degree,...
Retrospective Cohort Study.
Background: Surgical site infection (SSI) after open cranial vault reconstruction (CVR), while relatively uncommon, has received little attention in the literature to date. Here, authors report our institution's experience with perioperative management of infectious complications following CVR for craniosynostosis and present first systematic review on this topic. Methods: The performed a retrospective chart patients syndromic nonsyndromic who underwent between 1990 2015 at single...
Study Design: Retrospective cohort study.Purpose: The primary objective of this study was to determine the incidence and risk factors for incidental durotomies during lumbar decompression surgeries. In addition, we aimed changes in patient-reported outcome measures (PROMs) based on durotomy status.Overview Literature: There is limited literature investigating affect patient reported measures. While majority research does not suggest differences complications, readmission, or revision rates,...
Study Design: This was a retrospective cohort study. Objective: The objective of this study to determine if the degree interbody cage lordosis and positioning are associated with changes in postoperative sagittal alignment after single-level transforaminal lumbar fusion (TLIF). Summary Background Data: Ideal lumbopelvic have been shown correlate clinical outcomes. TLIF is one technique that may improve these parameters, but whether amount improves either segmental or (LL) unknown. Methods: A...