A5055298288- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Extracellular vesicles in disease
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
Consejo Nacional de Investigaciones Científicas y Técnicas
2018-2021
Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia
2018-2021
Abstract Epithelial to mesenchymal transition (EMT) is a critical cellular process that has been well characterized during embryonic development and cancer metastasis it also implicated in several physiological pathological events including stem cell differentiation. During early stages of differentiation, human cells pass through EMT where deeper morphological, molecular biochemical changes occur. Though initially considered as decision between two states, now regarded fluid exist on...
Mesenchymal stem/stromal cells (MSCs) obtained from pluripotent stem (PSCs) constitute an interesting alternative to classical MSCs in regenerative medicine. Among their many mechanisms of action, MSC extracellular vesicles (EVs) are a potential suitable substitute for future cell-free-based therapeutic approaches. Unlike cells, EVs do not elicit acute immune rejection, and they can be produced large quantities stored until ready use. Although the has already been proven, thorough...
Epithelial to mesenchymal transition (EMT) is a critical cellular process that has been well characterized during embryonic development and cancer metastasis it also implicated in several physiological pathological events including stem cell differentiation. During early stages of differentiation, human cells pass through EMT where deeper morphological, molecular biochemical changes occur. Though initially considered as decision between two states, now regarded fluid exist on spectrum...
Mesenchymal Stem Cells derived from induced Pluripotent cells (iPSC-MSC) have become a promising alternative to classical in regenerative medicine. Their properties -as immunomodulatory and capacities-are part due the secretion of Extracellular Vesicles (EVs). Small EVs (sEVs) with sizes that range 50 120 nm contain proteins, lipids, nucleic acids exert role cellular communication. content will depend on cell origin its physiological state, thus message they convey might change response...