A5015778816- Cardiac Imaging and Diagnostics
- Advanced X-ray and CT Imaging
- Pancreatic function and diabetes
- Radiation Dose and Imaging
- Genetic factors in colorectal cancer
- Coronary Interventions and Diagnostics
- Cell death mechanisms and regulation
- Colorectal Cancer Treatments and Studies
- Aortic Disease and Treatment Approaches
- Cardiac Valve Diseases and Treatments
- Advanced MRI Techniques and Applications
- ATP Synthase and ATPases Research
- Endoplasmic Reticulum Stress and Disease
- Glycosylation and Glycoproteins Research
- Protein Hydrolysis and Bioactive Peptides
- Pancreatitis Pathology and Treatment
- Colorectal and Anal Carcinomas
- Infective Endocarditis Diagnosis and Management
- MicroRNA in disease regulation
- Monoclonal and Polyclonal Antibodies Research
- PARP inhibition in cancer therapy
- Diabetes and associated disorders
- Lymphoma Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Corporate Management and Leadership
GALAB Laboratories (Germany)
2024
Friedrich-Alexander-Universität Erlangen-Nürnberg
2013-2017
University of Liechtenstein
2017
Royal College of Surgeons in Ireland
2009-2017
Universitätsklinikum Erlangen
2017
Siemens (Austria)
2014
Molecular Medicine Ireland
2012
Zug Cantonal Hospital
1984
ObjectiveTo evaluate the image quality and diagnostic accuracy of very low-dose computed tomography (CT) angiography (CTA) for evaluation coronary artery stenosis.
<h3>Objective</h3> Key to the clinical management of colorectal cancer is identifying tools which aid in assessing patient prognosis and determining more effective personalised treatment strategies. We evaluated whether an experimental systems biology strategy analyses susceptibility cells undergo caspase activation can be exploited predict responses 5-fluorouracil-based chemotherapy case-specifically identify potential alternative targeted treatments reactivate apoptosis. <h3>Design</h3>...
Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults. GBM cells are highly resistant to apoptosis induced by antitumor drugs radiotherapy resulting cancer progression. We assessed whether a systems medicine approach, analysing ability of execute could be utilized predict response patients treatment. Concentrations key proapoptotic proteins procaspase-3, procaspase-9, Smac Apaf-1 antiapopotic protein XIAP were determined panel cell lines patient resections. These...
Mutations in the transcription factor hepatocyte nuclear factor-1-alpha (HNF1A) result commonest type of maturity onset diabetes young (MODY). HNF1A-MODY carriers have reduced pancreatic beta cell mass, partially due to an increased rate apoptosis. To date, it has not been possible determine when apoptosis is occurring HNF1A-MODY.We recently demonstrated that stimulates expression stone protein/regenerating (PSP/reg) gene surviving neighbour cells, and PSP/reg1A protein subsequently secreted...
MicroRNA (miRNA) are a class of non-coding, 19-25 nucleotide RNA critical for network-level regulation gene expression. miRNA serve as paracrine signaling molecules. Using an unbiased array approach, we previously identified elevated levels miR-224 and miR-103 to be associated with monogenic form diabetes; HNF1A-MODY. is novel in the field diabetes. We sought explore role potential biomarker diabetes, whether such diabetes-associated-miRNA can also detected urine patients. Absolute were...
Complex repertoires of IgG autoantibodies have been detected against ocular antigens in patients with glaucoma. The goal was to identify and characterize the autoantibody sera pseudoexfoliation glaucoma (PXFG) protein macroarrays.Serum samples 21 PXFG 19 age- sex-matched control subjects were profiled on high-density colony macroarrays expressing His-tagged recombinant human proteins derived from a fetal brain cDNA library. Statistically prevalent expression clones group sequenced. mRNA...
Critical to successful execution of mitochondrial-mediated apoptosis is apoptosome formation and subsequent activation caspases. Defects in this pathway have an important role colorectal carcinogenesis chemoresistance; therefore, the expression apoptosome-associated proteins may be associated with clinical outcome response chemotherapy. Here we performed a systematic analysis immunohistochemical key involved apoptosome-dependent caspase (APAF1, Pro-caspases 9 3, SMAC, XIAP) cohort Stage II...
Abstract Background There is a significant clinical overlap between patients with hepatocyte nuclear factor (HNF)-1A and HNF4A maturity-onset diabetes of the young (MODY), two forms monogenic diabetes. HNF1A are transcription factors that control common partly overlapping sets target genes. We have previously shown elevated serum pancreatic stone protein / regenerating A (PSP/reg1A) levels can be detected in subjects HNF1A-MODY. In this study, we investigated whether PSP/reg differentially...
Cell death induced by excessive glutamate receptor overactivation, excitotoxicity, has been implicated in several acute and chronic neurological disorders. While numerous studies have demonstrated the contribution of biochemically genetically activated cell pathways excitotoxic injury, factors mediating passive, necrosis are less thoroughly investigated. To address this question, we developed a high content screening (HCS) based assay to collect volumes quantitative cellular imaging data...
Coopetition has received increasing attention in the academic literature. Prior research examined benefits and risks of coopetition as well its potential impact on innovation many different contexts, including large companies manufacturing industries. Surprisingly, despite omnipresence small- and- medium-sized enterprises (SMEs) growing relevance service industries, these contexts not yet been widely explored. This study seeks to broaden present understanding by finding an answer question...
Introduction Premature atherosclerosis is a significant cause of morbidity and mortality in type 2 diabetes mellitus. Maturity onset the young (MODY) accounts for approximately 2% all diabetes, with mutations transcription factor; hepatocyte nuclear factor 1 alpha (HNF1A) accounting majority MODY cases. There somewhat limited data available on prevalence macrovascular disease HNF1A-MODY carriers diabetes. Marked insulin resistance associated dyslipidaemia are not clinical features carriers....