A5112861037- Digital Holography and Microscopy
- Image Processing Techniques and Applications
- Advanced Fluorescence Microscopy Techniques
- CCD and CMOS Imaging Sensors
- Advanced Vision and Imaging
- Respiratory viral infections research
- SARS-CoV-2 detection and testing
- Photoacoustic and Ultrasonic Imaging
- Advanced Semiconductor Detectors and Materials
- Infection Control and Ventilation
- Advanced Electron Microscopy Techniques and Applications
- Advanced Chemical Sensor Technologies
- Microfluidic and Bio-sensing Technologies
- Advanced Biosensing Techniques and Applications
- Random lasers and scattering media
- Magnetic and Electromagnetic Effects
- Advanced X-ray Imaging Techniques
Imec the Netherlands
2024
IMEC
2017-2022
Imperial College London
2011
Oblique Plane Microscopy (OPM) is a light sheet microscopy technique that combines oblique illumination with correction optics tilt the focal plane of collection system. OPM can be used to image conventionally mounted specimens on coverslips or tissue culture dishes and has low out-of-plane photobleaching phototoxicity. No moving parts are required achieve an optically sectioned so high speed imaging possible. The first results obtained using NA water immersion lens commercially available...
The SARS-CoV-2 pandemic has highlighted the need for improved technologies to help control spread of contagious pathogens. While rapid point-of-need testing plays a key role in strategies rapidly identify and isolate infectious patients, current test approaches have significant shortcomings related assay limitations sample type. Direct quantification viral shedding exhaled particles may offer better approach, since is believed mainly by aerosols. It assesses contagiousness directly, easy...
A high pixel density image sensor for the Short Wave Infrared (SWIR) range is presented. PbS quantum dot (QD) photodiode array monolithically integrated on a silicon custom readout IC. Imaging in VIS and SWIR demonstrated using focal plane arrays with pitch down to record 1.82 μm. Through-silicon vision lens-free imaging (LFI) microscopy are shown as applications that can benefit from resolution/small dimensions. In LFI demonstration, captured hologram computationally reconstructed acquire...
Lens-free holographic microscopy (LHM) is a promising imaging technique for life science and industrial applications, yet system miniaturization cost reduction without compromising performance remain challenging field applications in low-resource settings. We demonstrate cost-effective LHM needs precision optical mechanical parts (such as lenses, beam-splitters, or kinematic stages) relies solely on robust optoelectronic hardware software co-design high imaging. The compact lightweight...
In this paper, we consider the task of detecting platelets in images diluted whole blood taken with a lens-free microscope. Despite having several advantages over traditional microscopes, imaging systems have significant challenge that resolution system is typically limited by pixel dimensions image sensor. As result resolution, very difficult even manual inspection due to fact occupy just few pixels reconstructed image. To address challenge, develop an optical model generate physically...
Abstract This study addresses the variations observed in electrorotation measurements due to cell positioning and movement. Electrorotation provides a non-disruptive method for inferring electrical properties of individual cells. However, its widespread adoption is hindered by significant variation speed. By mitigating impact positional dependencies other influencing factors, our methodology opens avenues broader applications single-cell analysis without need complex setups trap retain...
Lens-free imaging (LFI) has become an important microscopy tool in many life science and industrial applications. Due to the absence of optical lenses (such as objectives) accompanying lens aberrations chromatic aberrations), LFI modality is well suited for inspection microscopic objects a wide spectral range. However, relatively restricted sensitivity CMOS imagers, i.e. from visible (~400 nm) up near-infrared range (~900 nm), limits use technique. Many samples contain valuable information...
Abstract The SARS-CoV-2 pandemic has highlighted the need for improved technologies to help control spread of contagious pathogens. While rapid point-of-need testing plays a key role in strategies rapidly identify and isolate infectious patients, cornerstone any disease-control strategy, current test approaches have significant shortcomings related assay limitations sample type. Direct quantification viral shedding exhaled particles may offer better approach, since is believed mainly by...