A5103256120- Systemic Sclerosis and Related Diseases
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Skin Diseases and Diabetes
- Male Reproductive Health Studies
- Dietary Effects on Health
- Sperm and Testicular Function
- Telomeres, Telomerase, and Senescence
- Inflammatory Myopathies and Dermatomyositis
Instituto de Parasitología y Biomedicina "López - Neyra"
2022-2025
Systemic Risk Centre
2023
Universidad de Granada
2022
COVID-19 and systemic sclerosis (SSc) share multiple similarities in their clinical manifestations, alterations immune response, therapeutic options. These resemblances have also been identified other immune-mediated inflammatory diseases where a common genetic component has found. Thus, we decided to evaluate for the first time this shared architecture with SSc. For study, retrieved genomic data from two European-ancestry cohorts: 2,597 856 individuals The Host Genetics Initiative...
Although previous studies have suggested a relationship between telomere shortening and systemic sclerosis (SSc), the association these two traits remains poorly understood. The objective of this study was to assess causal length in leukocytes (LTL) SSc using two-sample Mendelian randomization approach, with genome-wide data for both LTL SSc. results inverse-variance weighted regression (OR = 0.716 [95% CI 0.528-0.970], p 0.031) pleiotropy residual sum outlier method 0.563-0.911], 0.035)...
<h3>Background:</h3> Systemic sclerosis (SSc) is a complex immune-mediated disease characterized by immune dysregulation, vascular damage and fibrosis. Its onset influenced many factors, including genetics. Notably, sex plays pivotal role with higher prevalence in females than males (8:1 ratio) different clinical manifestations between sexes. However, the underlying mechanisms of such differences have been unexplored remain poorly understood, contributing to health care disparities for women...
We aimed to analyze the role of common genetic variants located in PIN1 locus, a relevant prolyl isomerase required control proliferation spermatogonial stem cells and integrity blood-testis barrier, risk developing male infertility due severe spermatogenic failure (SPGF). Genotyping was performed using TaqMan genotyping assays for three taggers (rs2287839, rs2233678 rs62105751). The study cohort included 715 males diagnosed with SPGF classified as suffering from non-obstructive azoospermia...