Gonzalo Borrego‐Yaniz
A5092097709- Atherosclerosis and Cardiovascular Diseases
- Cell Adhesion Molecules Research
- Vasculitis and related conditions
- Systemic Sclerosis and Related Diseases
- Skin Diseases and Diabetes
- Biochemical Analysis and Sensing Techniques
- Food Safety and Hygiene
- Gut microbiota and health
- Inflammatory Myopathies and Dermatomyositis
- Lymphoma Diagnosis and Treatment
- Agriculture Sustainability and Environmental Impact
- Galectins and Cancer Biology
- Otitis Media and Relapsing Polychondritis
- Genetic Associations and Epidemiology
- Agricultural safety and regulations
- Probiotics and Fermented Foods
- Pharmaceutical and Antibiotic Environmental Impacts
- Systemic Lupus Erythematosus Research
Instituto de Parasitología y Biomedicina "López - Neyra"
2023-2025
Consejo Superior de Investigaciones Científicas
2024
This report describes the work developed during execution of Review Impact MICrobiome In Assesment (RIMICIA) project. project has performed a comprehensive and critical assessment evidence-based research about: i) impact dietary compounds in human some domestic animals (i.e., poultry, ruminants pigs) gut microbiome; ii) most representative vitro vivo models microbiota currently used microbiome studies; iii) methodology to measure changes microbiota. also gathered appraised information about...
COVID-19 and systemic sclerosis (SSc) share multiple similarities in their clinical manifestations, alterations immune response, therapeutic options. These resemblances have also been identified other immune-mediated inflammatory diseases where a common genetic component has found. Thus, we decided to evaluate for the first time this shared architecture with SSc. For study, retrieved genomic data from two European-ancestry cohorts: 2,597 856 individuals The Host Genetics Initiative...
Objectives. Giant cell arteritis (GCA) is a large-vessel vasculitis, potentially causing complications such as blindness and strokes. This study aims to gain insights into the pathogenesis of GCA by identifying specific DNA methylation signatures in arterial tissue patients with this vasculitis. Methods. profiling was analyzed 79 temporal artery biopsy samples (69 10 controls) performing an epigenome-wide association (EWAS). Differential analysis performed identify differentially methylated...
The gut microbiome is indispensable for the host physiological functioning. Yet, impact of non-nutritious dietary compounds on human microbiota and role microbes in their metabolism potential adverse biological effects have been overlooked. Identifying hazards benefits would contribute to protecting harnessing microbiome’s supporting health. We discuss evidence detrimental certain food additives microplastics health endpoints, with a focus underlying mechanisms causality. provide...
<h3>Background:</h3> Giant cell arteritis (GCA) is a vasculitis characterised by persistent inflammation of medium and large-sized arteries, particularly the aorta its branches. This disease associated with significant morbidity mortality, including risk vision loss stroke. Despite need to unravel GCA pathogenesis, mechanisms underlying development remain incompletely elucidated. Epigenetic modifications, such as DNA methylation, play crucial role in regulating gene expression can be...
<h3>Background:</h3> Systemic sclerosis (SSc) is a complex immune-mediated disease characterized by immune dysregulation, vascular damage and fibrosis. Its onset influenced many factors, including genetics. Notably, sex plays pivotal role with higher prevalence in females than males (8:1 ratio) different clinical manifestations between sexes. However, the underlying mechanisms of such differences have been unexplored remain poorly understood, contributing to health care disparities for women...
<h3>Background</h3> Giant cell arteritis (GCA) is a chronic large-vessel vasculitis that affects mainly the aorta and its primary branches, in Western countries most common form of people older than 50 years. The severe manifestations GCA include blindness ischemic stroke caused by occlusion affected arteries. presents complex aetiology whose genetic component remains largely unknown. Currently, options for both diagnosis treatment this pathology are limited, highlighting need to better...