A5031330901- Animal Nutrition and Physiology
- Salmonella and Campylobacter epidemiology
- Animal Virus Infections Studies
- Virology and Viral Diseases
- Microbial infections and disease research
- Escherichia coli research studies
- Antibiotic Resistance in Bacteria
- Animal Disease Management and Epidemiology
- Veterinary medicine and infectious diseases
- Viral gastroenteritis research and epidemiology
- Livestock and Poultry Management
- Animal Behavior and Welfare Studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Antibiotics Pharmacokinetics and Efficacy
- Vector-Borne Animal Diseases
- Mosquito-borne diseases and control
- Plant Virus Research Studies
- Odor and Emission Control Technologies
- Listeria monocytogenes in Food Safety
- Influenza Virus Research Studies
- Coccidia and coccidiosis research
- Insect and Pesticide Research
- Viral Infections and Immunology Research
- Agricultural safety and regulations
- Veterinary Pharmacology and Anesthesia
Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail
2015-2024
CEA Paris-Saclay
2022-2023
Physiologie Environnement et Génétique pour l'Animal et les Systèmes d'Elevage
2017
Université Européenne de Bretagne
2015-2016
Université Bretagne Loire
2015
Centre Technique de la Conservation des Produits Agricoles
2006
Poultry meat is the major source of human campylobacteriosis, most frequently reported zoonosis in EU. The prevalence Campylobacter colonization European broiler flocks 71%. Despite considerable efforts, there still no effective strategy available to prevent or reduce broilers. This study tested a wide variety feed additives shedding primary poultry production. Twelve containing organic fatty acids, monoglycerides, plant extracts, prebiotics, probiotics were tested. For each additive,...
This report describes the work developed during execution of Review Impact MICrobiome In Assesment (RIMICIA) project. project has performed a comprehensive and critical assessment evidence-based research about: i) impact dietary compounds in human some domestic animals (i.e., poultry, ruminants pigs) gut microbiome; ii) most representative vitro vivo models microbiota currently used microbiome studies; iii) methodology to measure changes microbiota. also gathered appraised information about...
In conventional rearing systems, fast-growing broiler chickens commonly experience welfare issues, such as contact dermatitis, walking difficulties or a lack of expression species-specific behaviours. Enriching their environment may be way to improve welfare. The objective this study was evaluate the benefits elevated platforms and straw bales on reared at two different stocking densities. A total 14,994 Ross 308 broilers were housed in 12 pens according 4 treatments: 31 kg/m2 with without...
Conventional broiler production needs to evolve towards more animal-friendly systems in order meet increasing consumer concerns regarding animal welfare. Genetics and stocking density are 2 of the most promising leads make this change possible. In study, 6 strains with different growth rates (42-61 g/d) were reared at contrasting densities: 37 kg/m² (HD) 29 (LD). At same body weight 1.80-1.95 kg, we evaluated how rate influenced behaviors (general activity, interactions enrichments), health...
Research was carried out to determine the effectiveness of 4 hatching eggs disinfection processes (i.e., disinfecting products and administration method) using a multi-pronged approach assessing reduction microbial eggshell contamination, effects on worker exposure, results broiler performance, and, finally, suitability for use in commercial hatcheries. The were: sodium dichlorocyanurate (DC) by thermonebulization, hydrogen peroxide 6% nebulization (HP6), electrolyzed oxidizing water (EOW)...
Infectious bursal disease virus (IBDV) is the causative agent of a highly contagious immunosuppressive affecting young chickens. The recently described "distinct IBDV" (dIBDV) genetic lineage encompasses group worldwide distributed strains that share conserved characteristics in both genome segments making them unique within IBDV strains. Phenotypic characterization these scarce and limited to Asiatic European collected more than 15 years ago. present study aimed assess complete...
Campylobacteriosis is reported to be the leading zoonosis in Europe, and poultry main reservoir of Campylobacter. Despite all efforts made, there still no efficient vaccine fight this bacterium directly poultry. Recent studies have interactions between chicken immune system gut microbiota response Campylobacter colonisation. The present study was designed analyse more depth responses caecal following vaccination with a DNA prime/protein boost flagellin-based that induces some protection...
Infectious bursal disease virus (IBDV) is a Birnaviridae family member of economic importance for poultry. This infects and destroys developing B lymphocytes in the cloacal bursa, resulting potentially fatal or immunosuppressive chickens. Naturally occurring viruses many vaccine strains are not able to grow vitro systems without prior adaptation, which often affects viral properties such as virulence. Primary cells, main target cells lymphotropic IBDV vivo, may represent an attractive system...
Immunosuppression in poultry production is a recurrent problem worldwide, and one of the major viral immunosuppressive agents Infectious Bursal Disease Virus (IBDV). IBDV infections are mostly controlled by using live-attenuated vaccines. Live-attenuated (IBD) vaccine candidates classified as “mild,” “intermediate,” “intermediate-plus” or “hot” based on their residual properties. The immunosuppression protocol described European Pharmacopoeia (Ph. Eur.) uses lethal Newcastle (NDV) infectious...
This study was designed to improve the hatching performance, chick robustness and poultry health in event of long-term egg storage suboptimal age reproductive flock. A total 9,600 eggs from one young breeder flock (28 weeks age, batch B) an older (59 E) were used (ROSS 308). Each separated into three sub-groups stored for 14 days. The first sub-group (Cool, group C) at 11.6°C. second (Warm, W) 18.3°C with two pre-incubation on days 6 10 period. final (Control, Ct) throughout Eggs similarly...
Anorexigenic substances released during infection may hinder the therapeutic efficacy of in-feed antibiotics. Paracetamol (acetaminophen; PARA) inhibits anorexia and seems to improve clinical doxycycline (DOX) against bacterial respiratory disease in swine herds. In order verify whether PARA selectively stimulates intake DOX-medicated feed diseased pigs, we documented pharmacokinetics (PK) DOX when coadministered with examined effect on interindividual variability plasma concentrations after...
Avian pathogenic Escherichia coli (APEC) cause extra-intestinal infections called colibacillosis, which is the dominant bacterial disease in broilers. To date, given diversity of APEC strains and need for an acceptable level protection day-old chicks, no satisfactory commercial vaccine available. As part a French nationwide project, we selected three representative among several hundred that colibacillosis disease. We first performed experiments to develop vivo models, using inoculum 3 × 107...
Campylobacter infections, traced to poultry products, are major bacterial foodborne zoonoses, and vaccination is a potential solution reduce these infections. In previous experimental trial using plasmid DNA prime/recombinant protein boost vaccine regimen, two candidates (YP437 YP9817) induced partially protective immune response against in broilers, an impact of the batch on efficacy was suspected. This new study designed evaluate different batches previously studied recombinant proteins...
The antigenic characterization of IBDV, a virus that causes an immunosuppressive disease in young chickens, has been historically addressed using cross neutralization (VN) assay and antigen-capture enzyme-linked immunosorbent (AC-ELISA). However, VN usually carried out either specific antibody negative embryonated eggs, for non-cell culture adapted strains, which is tedious, or on chicken embryo fibroblasts (CEF), requires adaptation to cell culture. AC-ELISA provided crucial information...
Beak trimming in laying hens limits the negative consequences of injurious pecking, but could be prohibited by future regulations. This study assessed a combination management strategies during rearing period (objects, perches, music, human presence) and (scratching mats, objects, feed fiber supplementation) to raise non-beak-trimmed animals. The welfare performances beak-trimmed (T) (NT) ISA Brown birds were compared between groups with (E) or without (NE) these strategies, supplementation...
Abstract Infectious Bursal Disease Virus (IBDV), a member of the Birnaviridae family, causes an immunosuppressive disease in young chickens. Although several reverse genetics systems are available for IBDV, isolation most field-derived strains, such as very virulent IBDV (vvIBDV) and their subsequent rescue, has remained challenging due to lack replication those viruses vitro. Such rescue required either inoculation animals, embryonated eggs, or introduction mutations capsid protein (VP2)...