A5101610989- Drug Transport and Resistance Mechanisms
- Drug-Induced Hepatotoxicity and Protection
- Neonatal Health and Biochemistry
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Metabolism and Genetic Disorders
- Folate and B Vitamins Research
- Pharmacological Effects and Toxicity Studies
- Sulfur Compounds in Biology
- Heme Oxygenase-1 and Carbon Monoxide
- Alcohol Consumption and Health Effects
- Exercise and Physiological Responses
- Liver Diseases and Immunity
- Phytochemicals and Antioxidant Activities
- Rabbits: Nutrition, Reproduction, Health
- Antioxidant Activity and Oxidative Stress
- Amino Acid Enzymes and Metabolism
- Pharmacogenetics and Drug Metabolism
- Pediatric Hepatobiliary Diseases and Treatments
- Animal Nutrition and Physiology
- Biochemical effects in animals
- Neuroinflammation and Neurodegeneration Mechanisms
- Phytochemical Studies and Bioactivities
- Liver physiology and pathology
- Genomics, phytochemicals, and oxidative stress
Universidad de Salamanca
1995-2009
Universidad de Granada
2005
Hospital Clínico Universitario de Valladolid
2004
Gifu University
2001
University of Córdoba
2000
University of Concepción
1995
Service de la Santé Publique
1993
Hospital Universitario La Paz
1993
Universidad de León
1988
We studied the effect of cyclosporin A (CyA) on liver plasma membrane (LPM) composition, fluidity, and functions hepatic glutathione (GS) oxidative status. also evaluated ability S-adenosylmethionine (SAMe) to antagonize CyA-induced disturbances in rats. The animals were randomly divided into four groups treated daily with saline, CyA vehicle, CyA, SAMe plus respectively, for 1 week. Bile, blood, samples LPM vesicles obtained at end treatments. cholestasis was associated alterations...
SUMMARY 1. The effects of cyclosporine A (CyA) treatment on liver morphology, bile flow and biliary secretion acid, cholesterol phospholipid some plasma biochemical indicators function were examined. 2. Wistar rats treated i.p. with 10 or 20 mg CyA/kg per day for 1, 2, 3 4 weeks. 3. Treatment increased acid bilirubin concentration. Bile reduced in CyA‐treated animals. 4. All these effecs the drug appeared at 1 week after start enhanced during prolonged treatment. Cyclosporine A‐induced...
Abstract Free radicals and oxidative stress are involved in the pathogenic mechanisms of cardiovascular disease (CVD), diabetes cancer. Exercise is a useful strategy for preventing CVD but elderly persons it can enhance stress, which why some studies recommend antioxidant supplementation exercising subjects. This intervention study was performed on 320 subjects following Geriatric Revitalization Program (GEREPRO) to maintain physical health reduce risk. GEREPRO based regular exercise...
Summary Vitamin E, a topically administered antioxidant, reduces erythema, photoaging, photocarcinogenesis, edema, and skin hypersensitivity associated with exposure to ultraviolet B (UVB) radiation. Virgin olive oil, which also has antioxidant properties, the number of, delays onset of cancer induced by UVB radiation when used after sunbathing. Topical use sunbathing formulations that contain virgin oil vitamin E may therefore reduce delay UVB‐related in humans. We designed gels (lipogels)...
This study examines the ability of S-adenosyl-L-methionine to prevent or antagonize cyclosporine A-induced adverse effects on biliary secretion in rat. was administered as a single bolus 3, 5 and 8 hr before administering dose A, also concurrently with A for 1 2 wk. Acute preadministration attenuated cyclosporine-induced cholestasis inhibition bile acids, cholesterol phospholipid secretion. pretreatment wk simultaneous cotreatment not only maintained beneficial reported above but further...
1. The effect of high bilirubin loads (60 mumol/kg twice daily for 2 days) on glucuronosyltransferase activity and biliary excretion was studied in Wistar rats. 2. concentration serum increased from 1.1 mumol/l controls to 5.5 after pretreatment. 3. Bilirubin pretreatment led a 25% increase hepatic UDP-glucuronosyltransferase activity. Tm by 22% correlated positively with 4. output conjugated bile enhanced but no changes the proportion monoconjugates disconjugates were observed. 5. Our data...
An evaluation was made of the degree toughening asparagus during its storage through a study morphological and cellular differences xylem vascular bundles as function variety, thickness portion spear. Light microscopic examinations were carried out to determine cell wall quantify extent toughening. At same time fractions dietary fibre spear by means chemical extraction techniques. Statistically significant observed in both methods between varieties, thicknesses portions Different factors...
OBJETIVO: Verificar a influência da suplementação de vitaminas antioxidantes na dieta mulheres idosas que praticam exercícios físicos regulares, sobre o estresse oxidativo, indicadores saúde física e risco enfermidades cardiovasculares (ECV). MÉTODO: Foram observados dois grupos (S C) com idades entre 60 80 anos participantes um programa atividades físicas durante 58 semanas, freqüência três vezes por semana duração 50 55 minutos cada sessão. A habitual do Grupo S (n=36) foi suplementada...
Creatine kinase activity was measured in the seminal fluid of 70 males undergoing fertility studies. The average value obtained at 30 degrees C 333 +/- 197 IU/l (average SD). There no evidence a significant correlation between creatine enzymatic and density, active lineal motility, or number normal motile spermatozoa; nor there any seen concentration citric acid, (indicator prostatic function) fructose, vesicle function). Nonetheless, two cases excretory azoospermia, very high values (2510...
Abstract Background/Introduction Altough malnutrition has been associated with higher mortality in heart failure (HF), information about its impact on community-dwelling older patients advanced HF remains scarce. Purpose This study is aimed at determining the prevalence and of HF. Methods A prospective multicenter included a cohort New York Heart Association IV (NYHA) functional status, or those NYHA III who had needed hospitalisation least twice previous six months. total 22 primary...