A5101903933- Lipid metabolism and disorders
- Chronic Kidney Disease and Diabetes
- Phytochemistry and Biological Activities
- Traditional Chinese Medicine Analysis
- Ovarian function and disorders
- Bioactive natural compounds
- Cancer-related molecular mechanisms research
- Pharmacological Effects of Medicinal Plants
- Polysaccharides and Plant Cell Walls
- Aquaculture Nutrition and Growth
- Microbial Community Ecology and Physiology
- Phytochemicals and Antioxidant Activities
- Reproductive Biology and Fertility
- Gastrointestinal motility and disorders
- Ferroptosis and cancer prognosis
- Crustacean biology and ecology
- Reproductive System and Pregnancy
- Marine and Coastal Ecosystems
- Invertebrate Immune Response Mechanisms
- TGF-β signaling in diseases
- Diet and metabolism studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Bone Metabolism and Diseases
- Drug-Induced Adverse Reactions
- Hops Chemistry and Applications
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2025
Nanjing University of Chinese Medicine
2019-2023
Zhejiang A & F University
2020
The spontaneous db/db mice were used to elucidate the biological effects and mechanisms of Rehmannia glutinosa leaves total glycoside (DHY) on kidney injury through biochemical indicators, pathological section analysis, metabolic profiling, intestinal flora analysis in vitro Human renal tubular epithelial (HK-2) cell model induced by high glucose. It was found that DHY can decrease blood sugar level (insulin, INS; fasting glucose, FBG), lipid (Total Cholesterol, T-CHO; Triglyceride, TG)...
Abstract In the process of planting and harvesting Rehmannia glutinosa , only underground part is used, a large number stems leaves that are considered non‐medicinal parts usually discarded. Recent studies have shown chemical components in similar to those identified roots. this study, we selected roots from at different growth stages cultivation regions investigate dynamic accumulation three kinds glycosides (catalpol, acteoside, ajugol), six carbohydrates (rhamnose, fructose, sucrose,...
This study was designed to investigate the protective effects and mechanisms of acteoside on DKD in diabetes male db/db mice high glucose‐induced HK‐2 cells. The were divided randomly into model group, metformin irbesartan group. We observed natural product exhibiting a significant effect renal protection through analyzing biochemical indicators endogenous metabolites, histopathological observations, western blotting. cells subjected glucose used invitro experiments. molecular them...
Although the Bushen Huoxue (BSHX) recipe is commonly used for effective treatment of prethrombotic state recurrent abortions, its mechanism action unclear. In this article, we investigated therapeutic effects BSHX on anti-cardiolipin antibody (ACA) positive miscarriage mice and molecular involved in ACA-positive miscarriages based PI3K-Akt signaling pathway, to provide a scientific basis clinical practice.An mouse model normal pregnancy were adopted experiment. Seventy CBA/J female induced...
The dissolved oxygen (DO) level is particularly important for marine benthic crustaceans. In Scylla paramamosain, the DO plays an role in regulating immune and metabolic responses. present study assessed whether effects of hypoxia on resistance S. paramamosain to Vibrio alginolyticus are related changes energy metabolism. hypoxic immune-related genes, Janus kinase, signal transducer activator transcription, Relish, Astakine were significantly downregulated hemocytes. contrast, inducible...
This study investigated the protective effects and mechanism of Tetrastigma hemsleyanum (T. hemsleyanum) in sarcoidosis mice. Through integrated analysis network pharmacology, molecular docking HPLC, oleanolic acid, procyanidin B1 β-sitosterol were considered to be major components T. against sarcoidosis. remarkably attenuated increase IL-6 IL-17A, percentage Th17 cells by 33. 85%-63.00% expression RORγt a dose-dependent manner (P < 0.01). Simultaneously, obviously elevated levels IL-35...
Diabetic kidney disease (DKD) is a common diabetic complication. Salvia miltiorrhiza has significant therapeutic effects on diabetes complications, although the mechanism remains unclear. Here, biochemical indicators and pathological changes were used to screen out optimal multi-bioactive compounds combination. Metabolomics, transcriptomics proteomics explore pathogenesis of DKD. RT-PCR parallel reaction monitoring targeted quantitative proteome analysis utilized investigate treatment...
Abstract Background : The frankincense and myrrh can be used in traditional Chinese medicine (TCM) clinic with the treatment of stroke, while its mechanism is still unclear. aim this study was to investigate effects boswellic acid (BA) sesquiterpene (MS) compositions on ischemic stroke rats. Methods rat model induced by ischemia-reperfusion (I/R) after transient middle cerebral artery occlusion (MCAO) adopted treated sesquiterpenes proportions compatibility (BA-MS) 10:1, 5:1 20:1....