A5045027912- Bipolar Disorder and Treatment
- Electroconvulsive Therapy Studies
- Schizophrenia research and treatment
- Dementia and Cognitive Impairment Research
- Treatment of Major Depression
- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Memory Processes and Influences
- Tryptophan and brain disorders
- Alzheimer's disease research and treatments
- Electrolyte and hormonal disorders
- Sleep and related disorders
- Intensive Care Unit Cognitive Disorders
- Suicide and Self-Harm Studies
- Visual and Cognitive Learning Processes
- Child and Animal Learning Development
- Reading and Literacy Development
- Neurological disorders and treatments
- Stress Responses and Cortisol
- Neurobiology of Language and Bilingualism
- Restless Legs Syndrome Research
- Child and Adolescent Psychosocial and Emotional Development
- Adolescent and Pediatric Healthcare
- Data Visualization and Analytics
- Maternal Mental Health During Pregnancy and Postpartum
University of Toronto
2024
University of California, Los Angeles
2010-2023
Neurobehavioral Systems
2012-2021
Weill Cornell Medicine
2021
Cornell University
2021
Stanford University
1996-2009
VA Palo Alto Health Care System
2006-2008
Veterans Health Administration
1993-2001
The University of Texas Health Science Center at Houston
1995
Palo Alto Veterans Institute for Research
1993
The Geriatric Depression Scale (GDS) is commonly used to measure depression in the elderly. However, there have been no reports of underlying structure GDS. To this end, GDS was administered 326 community-dwelling elderly subjects, and data were subjected a factor analysis. A five-factor solution selected and, after varimax rotation, factors that emerged could be described as: (1) sad mood, (2) lack energy, (3) positive (4) agitation, (5) social withdrawal. This accounted for 42.9% variance....
Article AbstractBackground: Many patients with bipolar disorder receive multi-drug treatment regimens, but the distinguishing profiles of who complex pharmacologies have not been established.Method: Prescribing patterns lithium, anticonvulsants, antidepressants, and antipsychotics were examined for 4035 subjects (DSM-IV) immediately prior to entering Systematic Treatment Enhancement Program Bipolar Disorder (STEP-BD). Subjects recruited participation across 22 centers in United States...
Objective To investigate the relations among initial perceived stress of Alzheimer patients' caregivers, rate change stress, sundowning behaviors, and cognitive decline. Design A longitudinal cohort study in which patients their caregivers were assessed at 6‐month intervals. Setting Hospital out‐patient clinic. Patients lived home. Subjects 35 (50–79 years) with Alzheimer's disease primary (24 males 11 females); all spouses. Methods At time entry into study, indicated seven behaviors...
ABSTRACT Autoimmune encephalitis is increasingly recognized as a neurologic cause of acute mental status changes with similar prevalence to infectious encephalitis. Despite rising awareness, approaches diagnosis remain inconsistent and evidence for optimal treatment limited. The following Canadian guidelines represent consensus (where available) based approach both the adult patients autoimmune were developed using modified RAND process included input from specialists in neurology,...
Abstract Inflammation plays a role in depression pathophysiology and treatment response, with effects varying by sex therapeutic modality. Lower levels of interleukin(IL)-8 predict response to antidepressant medication electroconvulsive therapy (ECT), although ECT are specific females. Whether IL-8 predicts ketamine sex-specific manner is not known. Here, depressed patients ( n = 46; female, 17) received open label infusion (0.5 mg/kg over 40 min; NCT02165449). Plasma were evaluated at...
Background There are many prognostic factors for treatment outcome in major depressive disorder (MDD). The predictive power of any single factor, however, is limited. We aimed to develop profiles antidepressant response and remission based upon hierarchical combinations baseline clinical demographic factors. Methods Using data from Level 1 the Sequenced Treatment Alternatives Relieve Depression trial (STAR*D), which 2,876 participants with MDD were treated citalopram, a signal-detection...
Background: Suicide prevention is a public health priority, but risk factors for suicide after medical hospitalization remain understudied. This problem critical women, whom rates in the United States are disproportionately increasing. Objective: To differentiate of attempt and self-harm following general among women with depression, bipolar disorder, chronic psychosis. Methods: We developed machine learning algorithm that identified using electronic record data from 1628 University...
Psychotropic medications are widely used in older adults and may cause neurocognitive deficits. Older at increased risk of developing adverse effects because age-related pharmacodynamic pharmacokinetic changes. This article provides a comprehensive review the undesirable, times beneficial, psychotropic medications. The covers wide range that impair executive function, memory, attention, as well much smaller group lead to improved function. Some most commonly adults, namely, antidepressants,...
To assess the longitudinal effects of acety-L-carnitine (ALC) on patients diagnosed with Alzheimer's disease.Longitudinal, double-blind, parallel-group, placebo-controlled.Twenty-four outpatient sites across United States.A total 334 subjects probable disease by NINCDS-ADRDA criteria. These data were originally reported Thal and colleagues (1996).Cognitive subscale Alzheimer Disease Assessment Scale (ADAS) given every 3 months for 1 year.The average rate change was estimated using trilinear...
The Mini-Mental State Examination (MMSE) is a commonly used instrument for assessing mental impairment. Previous proposals its underlying structure have focused on scores obtained from single administration of the test. Because MMSE widely in longitudinal studies, we examined pattern relations among rates chance items. Data were 63 subjects 1.5 years or more. change items described by five-factor solution that accounted 75% variance and comprised factors pertaining to orientation...
This study developed risk profiles of psychiatric hospitalization for veterans diagnosed as having bipolar disorder.This included 2,963 disorder (types I, II, or not otherwise specified) during the 2004 fiscal year. Data were derived from Veterans Affairs administrative database. Risk generated with an iterative application receiver operating characteristic.In this sample 20% patients hospitalized psychiatrically one-year period. Patients both alcohol use and polysubstance dependence who...
Brooks JO III, Bearden CE, Hoblyn JC, Woodard SA, Ketter TA. Prefrontal and paralimbic metabolic dysregulation related to sustained attention in euthymic older adults with bipolar disorder. Bipolar Disord 2010: 12: 866–874. © 2010 The Authors. Journal compilation John Wiley & Sons A/S. Objective: Reports of deficits the phase disorder have been variable, yet be cerebral metabolism. In present study, we evaluated relationships between cognitive performance resting metabolism Methods:...
Article AbstractContext: Practitioners often combine 2 or more second-generation antipsychotics (SGAs) in patients with bipolar disorder, despite an absence of data to support their safety, tolerability, efficacy. Objective: This study sought evaluate the safety and tolerability SGA polytherapy compared monotherapy disorder receiving open naturalistic treatment 22-site Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD). Method: A longitudinal cohort 1,958 who were...