A5064403012- Peripheral Neuropathies and Disorders
- Myasthenia Gravis and Thymoma
- Inflammatory Myopathies and Dermatomyositis
- Parkinson's Disease and Spinal Disorders
- Autoimmune Neurological Disorders and Treatments
- Genetic Neurodegenerative Diseases
- Muscle Physiology and Disorders
- Peripheral Nerve Disorders
- Cardiomyopathy and Myosin Studies
- Antifungal resistance and susceptibility
- Hereditary Neurological Disorders
- Erythrocyte Function and Pathophysiology
- Caveolin-1 and cellular processes
- Respiratory Support and Mechanisms
- Spine and Intervertebral Disc Pathology
- Innovations in Medical Education
- Pituitary Gland Disorders and Treatments
- Ion channel regulation and function
- Musculoskeletal Disorders and Rehabilitation
- Alcoholism and Thiamine Deficiency
- Neurogenetic and Muscular Disorders Research
- Congenital Diaphragmatic Hernia Studies
- Chronic Lymphocytic Leukemia Research
- Cancer Immunotherapy and Biomarkers
- Hedgehog Signaling Pathway Studies
Mayo Clinic
2021-2025
University of Alberta
2016-2025
Women and Children’s Health Research Institute
2017-2025
WinnMed
2022-2025
National Institute of Arthritis and Musculoskeletal and Skin Diseases
2024
Johns Hopkins University
2024
Mayo Clinic in Florida
2020-2022
Mayo Clinic in Arizona
2021-2022
University of Tasmania
2021
Menzies School of Health Research
2021
Neuromuscular ultrasound (NMUS) is gaining prominence as a valuable tool for diagnosing neuromuscular disorders at the point of care. disorder diagnostic criteria guidelines have begun incorporating NMUS findings. As interest grows, fellowship programs must consider training into their curricula. This study evaluated current state training, potential barriers, and in across Canadian programs. A 23-question online survey was developed distributed via email to all 10 program directors Canada....
Rippling Muscle Disease (RMD) is a rare skeletal myopathy characterized by abnormal muscular excitability manifesting with wave-like muscle contractions and percussion-induced mounding. Hereditary RMD associated caveolin-3 or cavin-1 mutations. Recently, we identified cavin 4 autoantibodies as biomarker of immune-mediated (iRMD), though the underlying disease-mechanisms remain poorly understood. Transcriptomic studies were performed on biopsies 8 patients (5 males; 3 females; ages 26-to-80)...
ABSTRACT Introduction : Rituximab appears to be beneficial in treatment‐refractory myasthenia gravis (MG); however, prospective, long‐term durability data are lacking. Methods In this open‐label study of rituximab refractory MG, 22 patients (10 nicotinic acetylcholine receptor, 9 muscle‐specific tyrosine kinase, 3 seronegative) received at baseline, with repeat cycles driven by clinical worsening. Manual muscle testing (MMT) scores and CD19/CD20 + B‐cell counts were serially monitored....
ABSTRACT Autoimmune encephalitis is increasingly recognized as a neurologic cause of acute mental status changes with similar prevalence to infectious encephalitis. Despite rising awareness, approaches diagnosis remain inconsistent and evidence for optimal treatment limited. The following Canadian guidelines represent consensus (where available) based approach both the adult patients autoimmune were developed using modified RAND process included input from specialists in neurology,...
<h3>Objective:</h3> To investigate the efficacy, tolerability, and safety of subcutaneous immunoglobulin (SCIg) in patients with mild to moderate myasthenia gravis (MG) exacerbation. <h3>Methods:</h3> We performed a prospective, open-label, phase 3 trial MG aged 18 years or older worsening (transition from Myasthenia Gravis Foundation America class I II/III II III), treated SCIg (2 g/kg), self-administered over 4 weeks. The primary endpoint was change quantitative (QMG) score baseline study...
<h3>Importance</h3> Immune-mediated rippling muscle disease (iRMD) is a rare myopathy characterized by wavelike contractions (rippling) and percussion- or stretch-induced mounding. A serological biomarker of this lacking. <h3>Objective</h3> To describe novel autoantibody iRMD report associated clinicopathological characteristics. <h3>Design, Setting, Participants</h3> This retrospective cohort study evaluated archived sera from 10 adult patients at tertiary care centers the Mayo Clinic,...
ABSTRACT Background Idiopathic inflammatory myopathies, beyond inclusion body myositis ( IBM ), have demonstrated an increased risk of adverse cardiovascular outcomes, particularly myocardial infarction MI ). This study evaluated the disease in . Methods We conducted a non‐concurrent cohort utilizing expanded Rochester Epidemiologic Project, including 50 patients with , matched 1:6 to age‐, sex‐, and calendar year‐matched referents without Baseline factors were recorded. Differences baseline...
Abstract Mitochondrial myopathies are frequently recognized in childhood as part of a broader multisystem disorder and often overlooked adulthood. Herein, we describe the phenotypic genotypic spectrum long-term outcomes mitochondrial diagnosed adulthood, focusing on neuromuscular features, electrodiagnostic myopathological findings survival. We performed retrospective chart review adult patients with myopathy at Mayo Clinic (2005–21). identified 94 patients. Median time from symptom onset to...
Point-of-care neuromuscular ultrasound (NMUS) is increasingly used in the evaluation of peripheral nervous system disorders; however, there remains a gap education and training for neurology residents. We evaluated whether residents can feasibly be trained basic NMUS skills nerve cross-sectional area (CSA) measurement they value incorporation this into their curriculum.
Abstract Objectives To investigate immune-mediated necrotizing myopathy (IMNM) association with cancer and its clinical implications. Methods IMNM cases were identified 1 January 2000 to 31 December 2020 matching sex age controls (4:1). Results A total of 152 patients among serologically tested, 60% (83/140) HMGCR-IgG+, 14% (20/140) SRP-IgG+ 26% (37/140) seronegative. Cancer rates not significantly different between serological subgroups; 18.1% (15/83) 25% (5/20) 30% (11/37) seronegative (P...
Abstract Introduction/Aims Point‐of‐care ultrasound of the diaphragm is highly sensitive and specific in detection neuromuscular diaphragmatic dysfunction. In some patients with dysfunction, paradoxical thinning during inspiration observed on ultrasound; however, its frequency, electrodiagnostic associations, prognostic significance remain uncertain. Methods Medical records presenting to two laboratories (Mayo Clinic, Rochester, Minnesota University Alberta, Edmonton, Alberta) from January...
Serial dissection of porcine motion segments during robotic control vertebral kinematics.To identify which spinal tissues are loaded in response to manual therapy (manipulation and mobilization) what magnitude.Various theoretical constructs attempt explain how therapies load specific tissues. By using a parallel robot kinematics serial dissection, it is possible quantify the loads experienced by discrete undergoing common therapeutic procedures such as therapy.In 9 cadavers, was provided L3...
To investigate the pathophysiologic mechanisms underlying immune-mediated Rippling Muscle Disease (iRMD).
To characterize clinical, electrophysiological, radiologic, pathological, and treatment outcomes of monomelic presentations pathologically confirmed chronic inflammatory demyelinating neuropathies (CIDP).
To longitudinally investigate patients with multifocal acquired demyelinating sensory and motor neuropathy (MADSAM), quantifying timing location of involvements in onset patients, along clinicohistopathologic electrophysiologic findings to ascertain differences without monoclonal gammopathy uncertain significance (MGUS).Patients MADSAM seen at Mayo Clinic tested for ganglioside antibodies were retrospectively reviewed (January 1, 2007-December 31, 2018).Of 76 MADSAM, 53% had pure motor, 16%...