A5046374875- Medical Imaging Techniques and Applications
- Advanced X-ray and CT Imaging
- Advanced MRI Techniques and Applications
- Ear Surgery and Otitis Media
- Radiation Dose and Imaging
- Blockchain Technology Applications and Security
- Scientific Computing and Data Management
- Research Data Management Practices
- MRI in cancer diagnosis
- Head and Neck Surgical Oncology
- Meningioma and schwannoma management
- Hearing Loss and Rehabilitation
- Angiogenesis and VEGF in Cancer
- Bone health and treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Orthopedic Surgery and Rehabilitation
- Oral and Maxillofacial Pathology
- Cystic Fibrosis Research Advances
- Cell Adhesion Molecules Research
- Sinusitis and nasal conditions
- Cerebral Venous Sinus Thrombosis
- Facial Trauma and Fracture Management
- Inhalation and Respiratory Drug Delivery
- Neonatal Respiratory Health Research
- Cardiac Imaging and Diagnostics
Heidelberg University
2007-2023
University Hospital Heidelberg
2010-2023
University Medical Centre Mannheim
2012-2023
Robert Bosch (Germany)
2023
Alexander von Humboldt Institute for Internet and Society
2016-2018
German Cancer Research Center
2008-2016
Klinik und Poliklinik für Nuklearmedizin
2010-2014
University Medical Center
2013
Heidelberger Institut für Radioonkologie
2008-2012
Medizinische Hochschule Hannover
2002-2009
Angiogenesis is not only dependent on endothelial cell invasion and proliferation, it also requires pericyte coverage of vascular sprouts for stabilization walls. Clinical efficacy angiogenesis inhibitors targeting the growth factor (VEGF) signaling pathway still limited to date. We hypothesized that level vessel maturation critically involved in response antiangiogenic therapies. To test this hypothesis, we evaluated network spontaneously developing melanomas MT/ret transgenic mice after...
Angiogenesis is not only dependent on endothelial cell invasion and proliferation, it also requires pericyte coverage of vascular sprouts for stabilization walls. Clinical efficacy angiogenesis inhibitors targeting the growth factor (VEGF) signaling pathway still limited to date. We hypothesized that level vessel maturation critically involved in response antiangiogenic therapies. To test this hypothesis, we evaluated network spontaneously developing melanomas MT/ret transgenic mice after...
Antibody-conjugated gold nanoparticles have been applied as a biologically targeted contrast agent in live mice for one of the most widely used medical imaging methods, X-ray computed tomography. Such nanoprobes directed toward CD4 receptor lead to distinctly enhanced peripheral lymph nodes. This study demonstrates general feasibility specific living animals and discusses basic requirements use agent.
The objective of this publication is to provide guidance on radiological protection in the new technology cone beam computed tomography (CBCT). Publications 87 and 102 dealt with patient dose management (CT) multi-detector CT. applications CBCT associated issues are substantially different from those conventional perception that involves lower doses was only true initial applications. now used widely by specialists who have little or no training protection. This provides recommendations...
In the muscle-specific tyrosine kinase receptor gene MUSK, a heteroallelic missense and null mutation were identified in patient suffering from congenital myasthenic syndrome (CMS). We generated one mouse line carrying homozygous V789M musk (muskV789M/V789M mice) second hemizygous line, resembling genotype, with on allele an lacking domain (muskV789M/− mice). report here that muskV789M/V789M mice present no obvious abnormal phenotype regarding weight, muscle function viability. contrast,...
The aim of this study was to evaluate the effect an antiangiogenic treatment with vascular endothelial growth factor antibody bevacizumab in experimental model breast cancer bone metastasis and monitor osteolysis, soft tissue tumor, angiogenesis noninvasively by volumetric computed tomography (VCT) magnetic resonance imaging (MRI). After inoculation MDA-MB-231 human cells into nude rats, monitored contrast-enhanced VCT MRI from day 30 70 after tumor cell inoculation, respectively. Thereby,...
<b>BACKGROUND AND PURPOSE:</b> A recent development in radiology is the use of flat panel detectors CT to obtain higher-resolution images. This technique known as volume (fpVCT). We sought compare image quality and diagnostic value 2 different detector–equipped scanners: one a prototype fpVCT scanner, other so-called digital tomography (fpDVT) which routinely used clinical setup with current state-of-the-art multisection (MSCT) scanners. <b>MATERIALS METHODS:</b> Five explanted temporal...
The onset and spontaneous development of cystic fibrosis (CF) lung disease remain poorly understood. In the present study, we used volumetric computed tomography (VCT) as a new method for longitudinal in vivo monitoring early lesions progression CF-like β-epithelial Na + channel (ENaC)-transgenic (TG) mice. Using VCT scanner prototype (80 kV, 50 mA·s, scan time 19 s spatial resolution 200 μm), βENaC-TG mice wild-type (WT) littermates were examined longitudinally at 10 time-points from...
To determine impedance values and charge consumption following cochlear implantation post-meningitic deaf children depending on the grade of ossification obliteration.
Since its launch just over a decade ago by the cryptocurrency Bitcoin, distributed ledger technology (DLT) blockchain has followed breathtaking trajectory into manifold application spaces. This study aper analyses how key factors underpinning success of this ground-breaking “Internet value” technology, such as staking collateral (“skin in game”), competitive crowdsourcing, crowdfunding, and prediction markets, can be applied to substantially innovate legacy organization science, research,...
The goal of this study is to demonstrate the performance radiomics and CNN-based classifiers in determining primary origin gastrointestinal liver metastases for visually indistinguishable lesions.In retrospective, IRB-approved study, 31 pancreatic cancer patients with 861 lesions (median age [IQR]: 65.39 [56.87, 75.08], 48.4% male) 47 colorectal 435 65.79 [56.99, 74.62], 63.8% were enrolled. A pretrained nnU-Net performed automated segmentation 1296 lesions. Radiomics features each lesion...
Image-guided interventions are an increasingly important part of clinical minimally invasive procedures. However, up to now they cannot be performed under 4D (3D + time) guidance due the exceedingly high x-ray dose. In this work we investigate applicability compressed sensing reconstructions for highly undersampled CT datasets combined with incorporation prior images in order yield low dose intervention guidance. We present a new reconstruction scheme image dynamic interventional (PrIDICT)...
An overwhelming majority of experts has been flagging for decades that "Saving the Planet" requires immediate, persistent and drastic action to curb a variety catastrophic risks over 21st century. However, despite compelling evidence range suggested solutions, transnational coordination effective measures protect our biosphere continues fall short. To remedy, we propose novel platform addressing central issue affording trust, transparency truth while minimizing administrative overheads. This...
To evaluate the incremental value of low endothelial shear stress (ESS) combined with high-resolution magnetic resonance imaging (MRI)- and computed tomography angiography (CTA)-based for prediction inflamed plaque. Twelve hereditary hyperlipidaemic rabbits underwent quantitative analysis plaque in thoracic aorta 256-slice CTA USPIO-enhanced (ultra-small superparamagnetic nanoparticles, P904) 1.5-T MRI at baseline 6-month follow-up. Computational fluid dynamics using CTA-based 3D...