A5103139568- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Acute Myocardial Infarction Research
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Disease and Adiposity
- Lipoproteins and Cardiovascular Health
- Cardiovascular Health and Disease Prevention
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Function and Risk Factors
- Aortic aneurysm repair treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac Valve Diseases and Treatments
- Cardiac tumors and thrombi
- Protease and Inhibitor Mechanisms
- Cardiac Arrhythmias and Treatments
- Heart rate and cardiovascular health
- Heart Rate Variability and Autonomic Control
- Coronary Artery Anomalies
- Cardiac pacing and defibrillation studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Structural Anomalies and Repair
- Heart Failure Treatment and Management
- Kawasaki Disease and Coronary Complications
- Venous Thromboembolism Diagnosis and Management
University of Miami
2023-2025
University of Miami Health System
2024
University of Nebraska Medical Center
2015-2023
Scripps Clinic
2021
Brigham and Women's Hospital
2008-2017
Harvard University
2008-2017
Massachusetts General Hospital
2014-2017
Gazi Hastanesi
2017
Center for Systems Biology
2017
Nova Southeastern University
2017
Low endothelial shear stress (ESS) promotes the development of atherosclerosis; however, its role in progression atherosclerotic plaques and evolution to inflamed high-risk has not been studied. Our hypothesis was that lowest values ESS are responsible for coronary associated with excessive expansive remodeling.Twenty-four swine, treated streptozotocin induce diabetes fed a high-fat diet, were allocated into early (n=12) late atherosclerosis groups. Intima-media thickness assessed by...
Background— The natural history of heterogeneous atherosclerotic plaques and the role local hemodynamic factors throughout their development are unknown. We performed a serial study to assess endothelial shear stress (ESS) vascular remodeling in coronary atherosclerosis. Methods Results— Intravascular ultrasound-based 3-dimensional reconstruction all major arteries (n=15) was serially vivo 5 swine 4, 11, 16, 23, 36 weeks after induction diabetes mellitus hyperlipidemia. reconstructed were...
Superficial erosion currently causes up to a third of acute coronary syndromes; yet, we lack understanding its mechanisms. Thrombi because superficial intimal characteristically complicate matrix-rich atheromata in regions flow perturbation.This study tested vivo the involvement disturbed and neutrophils, hyaluronan, Toll-like receptor 2 ligation injury, process implicated erosion.In mouse carotid arteries with established lesions tailored resemble substrate human eroded plaques,...
Background- The molecular mechanisms that determine the localized formation of thin-capped atheromata in coronary arteries remain unknown. This study tested hypothesis low endothelial shear stress augments expression matrix-degrading proteases and thereby promotes atheromata. Methods Results- Intravascular ultrasound-based, geometrically correct 3-dimensional reconstruction 12 swine was performed vivo 23 weeks after initiation diabetes mellitus a hyperlipidemic diet. Local calculated...
The mechanisms promoting the focal formation of rupture-prone coronary plaques in vivo remain incompletely understood. This study tested hypothesis that regions exposed to low endothelial shear stress (ESS) favor subsequent development collagen-poor, thin-capped plaques.Coronary angiography and 3-vessel intravascular ultrasound were serially performed at 5 consecutive time points diabetic, hypercholesterolemic pigs. ESS was calculated along course each artery with computational fluid...
The authors estimated noninvasively the wall stress distribution for actual abdominal aortic aneurysms (AAAs) in vivo on a patient-to-patient basis and correlated peak (PWS) with various geometrical parameters. They studied 39 patients (37 men, mean age 73.7 +/- 8.2 years) an intact AAA (mean diameter 6.3 1.7 cm) undergoing preoperative evaluation spiral computed tomography (CT). Real 3-dimensional geometry was obtained from image processing. Wall determined by using finite-element analysis....
To investigate the wall shear stress oscillation in a normal human left coronary artery bifurcation computational model by applying non-Newtonian blood properties and phasic flow.The three-dimensional geometry of investigated included main along with its two branches, namely anterior descending circumflex artery. For analyses pulsatile flow was applied. evaluate cyclic variations stress, six characteristic time-points cardiac cycle were selected. The variation compared Newtonian one.The...