A5033790465- Platelet Disorders and Treatments
- Blood groups and transfusion
- Obesity, Physical Activity, Diet
- Heparin-Induced Thrombocytopenia and Thrombosis
- Public Health in Brazil
- Healthcare Regulation
- Cardiovascular Health and Disease Prevention
- Health and Lifestyle Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Nutritional Studies and Diet
- Blood Pressure and Hypertension Studies
- Cardiovascular Disease and Adiposity
- Adipokines, Inflammation, and Metabolic Diseases
- Atherosclerosis and Cardiovascular Diseases
- Antioxidant Activity and Oxidative Stress
- Cardiovascular Health and Risk Factors
- Retinal Diseases and Treatments
- Immune Response and Inflammation
- Physical Education and Gymnastics
- Body Composition Measurement Techniques
- Peripheral Artery Disease Management
- Potassium and Related Disorders
- Heart Rate Variability and Autonomic Control
- Protease and Inhibitor Mechanisms
- Problem and Project Based Learning
The Ohio State University Wexner Medical Center
2024
New York Hospital Queens
2021-2022
NewYork–Presbyterian Hospital
2021-2022
Cornell University
2021-2022
Weill Cornell Medicine
2021-2022
Presbyterian Hospital
2021-2022
Center for Systems Biology
2016-2017
Brigham and Women's Hospital
2016-2017
Harvard University
2013-2017
Massachusetts General Hospital
2016-2017
Macrophages reside in the healthy myocardium, participate ischemic heart disease, and modulate myocardial infarction (MI) healing. Their origin roles post-MI remodeling of nonischemic remote however, remain unclear.This study investigated number, origin, phenotype, function cardiac macrophages residing myocardium mice with chronic failure after coronary ligation.Eight weeks post MI, fate mapping flow cytometry revealed that a 2.9-fold increase results from both increased local macrophage...
Superficial erosion currently causes up to a third of acute coronary syndromes; yet, we lack understanding its mechanisms. Thrombi because superficial intimal characteristically complicate matrix-rich atheromata in regions flow perturbation.This study tested vivo the involvement disturbed and neutrophils, hyaluronan, Toll-like receptor 2 ligation injury, process implicated erosion.In mouse carotid arteries with established lesions tailored resemble substrate human eroded plaques,...
HIV infection has been considered as one of the major global public health threats last century, increasing several times mortality rate in comparison to cholera epidemic that swept London nineteenth century. Unlike contamination caused by bacillus, prevention requires other interventions than basic sanitation, and antiretroviral agents currently remain touchstone transform disease from subacute into a chronic condition. The introduction highly active therapy (HAART) treatment HIV-infected...
Cases of de novo immune thrombocytopenia (ITP), including a fatality, following SARS-CoV-2 vaccination in previously healthy recipients led to studying its impact preexisting ITP. In this study, 4 data sources were analyzed: the Vaccine Adverse Events Reporting System (VAERS) for cases ITP; 10-center retrospective study adults with ITP receiving vaccination; and surveys distributed by Platelet Disorder Support Association (PDSA) United Kingdom (UK) Association. Seventy-seven identified...
The association between clustering of risk factors and self-reported cardiovascular disease among women was investigated in a cross-sectional study using multistage population-based sample. Participants were interviewed at home about diabetes mellitus, physical activity, diet pattern. Hypertension defined as blood pressure > 140/90mmHg or use anti-hypertensive medication. Cardiovascular included myocardial infarction, heart failure, coronary artery bypass surgery, stroke. A sample 1,007...
Aims Mice deficient in IL-1 receptor 1 (hence unresponsive to both isoforms α and β) have impaired expansive arterial remodeling due diminished expression of matrix-degrading enzymes, especially MMP-3. Emergence as a target cardiovascular disease prompted the investigation redundancy IL-1α IL-1β induction MMP-3 other matrix-remodeling enzymes human cells. Methods Results Human primary vascular smooth muscle cells (VSMCs) carotid endarterectomy specimens were stimulated with equimolar...
Abstract Background Increased body weight has been associated with an unhealthy diet, low consumption of fruits and vegetables. Our objective was to investigate whether adolescents had intake vegetables, gender, age education could affect the feeding patterns. Methods A population-based sample adolescents, aged 12–19 years, were randomly selected in southern Brazil included this cross-sectional study. The total daily fruits, rice beans investigated standardized household interviews, using a...
Abstract Background Blood pressure (BP) variability has been associated with cardiovascular outcomes, but there is no consensus about the more effective method to measure it by ambulatory blood monitoring (ABPM). We evaluated association between three different methods estimate BP ABPM and ankle brachial index (ABI). Methods Results In a cross-sectional study of patients hypertension, was estimated time rate (the first derivative SBP over time), standard deviation (SD) 24-hour SBP;...
To analyze the effect of diabetes on general and cardiovascular disease (CVD) mortality morbidity in southern Brazil.A population-based cohort study 1,091 individuals was conducted. Diabetes ascertained by medical history. The vital status 982 incidence events were during another visit through hospital records, death certificates, verbal necropsy with relatives.The mean +/- SD age participants 43.1 17 years, 55.7% women. prevalence 4.2%, follow-up time 5.3 0.07 years. Mortality 36.3% 6.6% or...
Background Retinal arterial narrowing is associated with higher office blood pressure (BP) and ambulatory monitoring, increased incidence of cardiovascular disease, but it still unknown if the vessel caliber BP measured at time retinography acquisition. Methods arteriolar venular calibers were by microdensitometric method in 448 patients hypertension. Participants underwent 24-hours (24-h ABP) monitoring simultaneously Association between increase 10 mmHg mean 24-hours, daily, nightly BP,...
Hypertension is a complex chronic condition characterized by elevated arterial blood pressure. Management of hypertension includes non-pharmacologic strategies, which may include techniques that effectively reduce autonomic sympathetic activity. Respiratory exercises improve control over cardiovascular system and attenuate muscle metaboreflex. Because these effects, respiratory be useful to lower pressure in subjects with hypertension. This randomized, double-blind clinical trial will test...