A5076539221- Platelet Disorders and Treatments
- Autoimmune Bullous Skin Diseases
- Blood groups and transfusion
- Heparin-Induced Thrombocytopenia and Thrombosis
- Chronic Lymphocytic Leukemia Research
- Metabolism and Genetic Disorders
- Immunodeficiency and Autoimmune Disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Veterinary Equine Medical Research
- Muscle metabolism and nutrition
- Mitochondrial Function and Pathology
- Lymphoma Diagnosis and Treatment
- Blood properties and coagulation
- Biosimilars and Bioanalytical Methods
- Diphtheria, Corynebacterium, and Tetanus
- Animal Ecology and Behavior Studies
- Plant-Derived Bioactive Compounds
- Adipose Tissue and Metabolism
- Cardiovascular and exercise physiology
- Systemic Sclerosis and Related Diseases
- Genital Health and Disease
- Clinical Laboratory Practices and Quality Control
- Hormonal and reproductive studies
- Urticaria and Related Conditions
- Forensic Toxicology and Drug Analysis
University of Liège
2019-2025
Hospital of the University of Pennsylvania
2024-2025
ME Association
2018
Over the last decade, there have been numerous developments and changes in treatment practices for management of patients with immune thrombocytopenia (ITP). This article is an update International Consensus Report published 2010. A critical review was performed to identify all relevant articles between 2009 2018. An expert panel screened, reviewed, graded studies formulated updated consensus recommendations based on new data. The final document provides diagnosis ITP adults, during...
Immune thrombocytopenia (ITP) has a substantial, multifaceted impact on patients' health-related quality of life (HRQoL). Data describing which aspects ITP physicians and patients perceive as having the greatest are limited. The World Impact Survey (I-WISh) was cross-sectional survey, including 1507 472 physicians, to establish HRQoL productivity from patient physician perspectives. Patients reported that reduced their energy levels (85% patients), capacity exercise (77%), limited ability...
Abstract Immune thrombocytopenia (ITP) is now well‐known to reduce patients' health‐related quality of life. However, data describing which signs and symptoms patients physicians perceive as having the greatest impact are limited, understanding full effects ITP treatments. I‐WISh (ITP World Impact Survey) was an exploratory, cross‐sectional survey designed establish multifaceted ITP, its treatments, on lives. It focused perceptions 1507 472 from 13 countries regarding diagnostic pathway,...
Cases of de novo immune thrombocytopenia (ITP), including a fatality, following SARS-CoV-2 vaccination in previously healthy recipients led to studying its impact preexisting ITP. In this study, 4 data sources were analyzed: the Vaccine Adverse Events Reporting System (VAERS) for cases ITP; 10-center retrospective study adults with ITP receiving vaccination; and surveys distributed by Platelet Disorder Support Association (PDSA) United Kingdom (UK) Association. Seventy-seven identified...
Hypoglycin A and methylenecyclopropylglycine are protoxins responsible for atypical myopathy in equids. These converted into toxins that inhibit fatty acid β-oxidation, leading to blood accumulation of acylcarnitines toxin conjugates, such as methylenecyclopropylacetyl-carnitine. The enzymes involved this activation also present some prokaryotic cells, raising questions about the potential role intestinal microbiota development intoxication. Differences have been noted between faecal...
Equine atypical myopathy (AM) is a severe environmental intoxication linked to the ingestion of protoxins contained in seeds and seedlings sycamore maple (Acer pseudoplatanus) Europe. The toxic metabolites cause frequently fatal rhabdomyolysis syndrome grazing horses. Since these can also be present cograzing horses, it still unclear as why, similar context, some horses show signs AM, whereas others remain clinically healthy. Label-free proteomic analyses on serum 26 diseased 23 cograzers,...
In 2014, atypical myopathy (AM) was linked to Acer pseudoplatanus (sycamore maple) in Europe. The emergence of this seasonal intoxication caused by a native tree has raised many questions. This manuscript aims at answering the five most frequently asked questions (FAQs) regarding (1) identification toxic trees; reduction risk level (2) pastures and (3) equids; (4) associated with sycamores that have always been used without horses being poisoned (5) length periods. Answers were found...
Thrombopoietin receptor agonists (TPO-RAs) are used to treat primary immune thrombocytopenia (ITP). Some patients have discontinued treatment while maintaining a hemostatic platelet count.
Acer pseudoplatanus is a worldwide-distributed tree which contains toxins, among them hypoglycin A (HGA). This toxin known to be responsible for poisoning in various species, including humans, equids, Père David’s deer and two-humped camels. We hypothesized that any herbivore pasturing with A. their vicinity may at risk HGA poisoning. To test this hypothesis, we surveyed the exposure from species not yet described as being risk. Animals zoological parks were major focus, they are high...
Equine atypical myopathy is caused by hypoglycin A (HGA) and methylenecyclopropylglycine (MCPrG), the known protoxins of sycamore maple (Acer pseudoplatanus). Various tissues from five cases were analyzed but only HGA was found. Whether deamination MCPrG has already occurred in intestine as first stage metabolization not been investigated. Activation to methylenecyclopropylacetyl (MCPA)-CoA methylenecyclopropylformyl (MCPF)-CoA, respectively, mainly skeletal muscles, evidenced very high...
Equine atypical myopathy (AM) is seasonal intoxication resulting from the ingestion of seeds and seedlings sycamore maple (Acer pseudoplatanus) that contain toxins, among them, hypoglycin A (HGA). Literature mentions several cases AM gravid mares in unweaned foals. The objective this study was to determine whether HGA and/or its metabolite are present milk grazing exposed trees as confirmed by detection their blood. Four mare/foal couples were included study. Both detectable all but one...
Abstract: Immune thrombocytopenia (ITP) is a rare heterogeneous autoimmune bleeding disorder that causes lower than normal circulating platelet count resulting from impaired production and accelerated destruction. Patients with ITP face complex set of challenges. The multifaceted burden living impacts the overall health-related quality life (HRQoL) patients their families. Here, we review patients' perspective on unmet needs, physical emotional disease in an attempt to highlight areas where...
Thoroughbred (TB) racehorses undergo rigorous conditioning programs to optimize their physical and mental capabilities through varied exercise sessions. While conventional investigations focus on limited hematological biochemical parameters, this field study employed untargeted metabolomics comprehensively assess metabolic responses triggered by sessions routinely used in TB conditioning. Blood samples were collected pre- post-exercise from ten racehorses, divided into two groups based...
To characterize pediatric neurologists' prescribing habits for preventive treatment of post-traumatic headache (PTH) in children.
Abstract Anne‐Christine François, Benoît Renaud, Caroline‐Julia Kruse, Christel Marcillaud‐Pitel and Dominique‐Marie Votion of the Atypical Myopathy Alert Group discuss insights from 20 years research surveillance on equine atypical myopathy.