A5083630742- Lysosomal Storage Disorders Research
- Cardiac Ischemia and Reperfusion
- Trypanosoma species research and implications
- Cardiovascular and exercise physiology
- Cardiac Fibrosis and Remodeling
- Redox biology and oxidative stress
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cardiovascular Disease and Adiposity
- Pulmonary Hypertension Research and Treatments
- Heart Rate Variability and Autonomic Control
- Adipokines, Inflammation, and Metabolic Diseases
- Protease and Inhibitor Mechanisms
- Nutrition and Health in Aging
- Adipose Tissue and Metabolism
- Agricultural and Food Sciences
- Antioxidant Activity and Oxidative Stress
- Mesenchymal stem cell research
- Nitric Oxide and Endothelin Effects
- Biochemical effects in animals
- Glycogen Storage Diseases and Myoclonus
- Cardiovascular Function and Risk Factors
- Science and Education Research
- Nutritional Studies and Diet
- Tissue Engineering and Regenerative Medicine
- Rural and Ethnic Education
Universidade Federal do Rio Grande do Sul
2013-2023
Hospital de Clínicas de Porto Alegre
2008-2020
Faculdade Redentor
2014
Hospital Israelita Albert Einstein
2010
Universidade Federal de Viçosa
1994
In this study, IgG fractions from sera of SLE patients with anti-Ro/SSA or and anti-La/SSB activity were tested in Langendorff preparations adult rabbit hearts, aiming to reproduce the cardiac manifestations observed neonatal lupus an experimental model. The hearts perfused normal Tyrode's solution for 30 min, followed by perfusion containing 0.3 mg/ml anti-Ro/SSA- (or anti-Ro/La-) positive (nine sera), anti-ribonucleoprotein (RNP)-positive (five donors sera). one third experiments done...
Bone marrow cell (BMC) therapy is thought to exert beneficial effects on the infarcted heart. We assessed cardiac function and its correlation with redox status inflammation in tissue early post-AMI rats treated BMC. Male Wistar (8-week-old) were randomized into four groups: Sham-operated (S); AMI; S + treatment (ST) AMI (AMIT). Therapy BMC was carried out immediately post-experimental left anterior coronary artery ligation induced-AMI, assessments made 48 h later. Cardiac morphometrics...
We investigated the myocardial thioredoxin-1 and hydrogen peroxide concentrations their association with some prosurvival pro-apoptotic proteins, during transition from infarction (MI) to heart failure in rats. Male Wistar rats were divided into following six groups: three sham-operated groups MI groups, each at 2, 7 28 days postsurgery. Cardiac function was analysed by echocardiography; concentration of H(2)O(2) ratio reduced oxidized glutathione measured spectrophotometrically, while...
Pulmonary arterial hypertension is characterized by progressive increases in resistance and pressure the pulmonary artery Cor pulmonale. The effect of exercise on hydrogen peroxide-dependent signaling right ventricle (RV) pulmonale rats was analyzed. Rats were divided into sedentary control (SC), monocrotaline (SM), trained (TC), (TM) groups. underwent training (60% VO2 max) for 5 weeks, with 3 weeks after injection (60 mg/kg intraperitoneally). enhanced SM (2.0-fold) compared SC. increased...
The aim of this study was to investigate the effect aging and timing left ventricular ischemic injury on availability functionality stem cells. We studied young aged male inbred Lewis rats that were used as donors bone marrow mononuclear cells (BM-MNCs), divided in four experimental groups: controls, sham operated, 48 h post-myocardial infarction (MI), 28 days post-MI. In vitro studies included flow cytometry analysis, hematopoietic colony-forming capacity, invasion assays migration...
Mucopolysaccharidosis type I (MPS I) is a progressive disorder caused by deficiency of α-L-iduronidase (IDUA), which leads to storage heparan and dermatan sulphate. It suggested that early enzyme replacement therapy (ERT) better outcomes, although many patients are diagnosed late don't receive immediate treatment. This study aims evaluate the effects onset ERT in MPS murine model. mice received treatment from 6 8 months age (ERT 6–8mo) with 1.2mg laronidase/kg every 2 weeks were compared...
The effects of purple grape juice (PGJ) pretreatment in signaling proteins involved cardiac remodeling rats with pulmonary arterial hypertension (PAH) induced by monocrotaline (MCT) were investigated. Male Wistar (control, MCT, PGJ, and MCT + PGJ groups) treated for 6 weeks water or (10 mL·kg(-1)·d(-1)) gavage. In the third week, they administered a single dose (60 mg/kg i.p.). Pulmonary vascular resistance was determined echocardiography, hemodynamic analysis performed right ventricle (RV)....
Copaiba oil comes from an Amazonian tree and has been used as alternative medicine in Brazil. However, it not investigated yet the treatment of cardiovascular diseases. This study was designed to test whether copaiba or nanocapsules containing this could modulate monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH). Male Wistar rats (170 ± 20 g) received (400 mg/kg) by gavage daily for 1 week. At end period, a single injection MCT (60 mg/kg i.p.) administered measurements were...