A5039326225- Nitric Oxide and Endothelin Effects
- Cardiac Ischemia and Reperfusion
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Heart Rate Variability and Autonomic Control
- Adipose Tissue and Metabolism
- Blood Pressure and Hypertension Studies
- Hormonal Regulation and Hypertension
- Cardiac electrophysiology and arrhythmias
- Receptor Mechanisms and Signaling
- Renin-Angiotensin System Studies
- Cardiomyopathy and Myosin Studies
- COVID-19 and Mental Health
- Thyroid Disorders and Treatments
- Cardiovascular Health and Disease Prevention
- Cardiac Arrest and Resuscitation
- Cardiovascular Function and Risk Factors
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiac Fibrosis and Remodeling
- Calpain Protease Function and Regulation
- Biochemical effects in animals
- Lipoproteins and Cardiovascular Health
- Vitamin C and Antioxidants Research
- Cholinesterase and Neurodegenerative Diseases
- Chemotherapy-induced cardiotoxicity and mitigation
- Spectroscopy Techniques in Biomedical and Chemical Research
Universidade Federal do Espírito Santo
2005-2024
Universidade Vila Velha
2024
Istituti di Ricovero e Cura a Carattere Scientifico
2022
Vita-Salute San Raffaele University
2016-2022
Universidade Federal do Rio Grande do Sul
2012-2015
Universitat Autònoma de Barcelona
2014
Vall d'Hebron Hospital Universitari
2010
University of Würzburg
2007
Universitätsklinikum Würzburg
2007
Mineralocorticoid receptor blockade improves mortality early after myocardial infarction (MI). This study investigated the vascular effects of mineralocorticoid in phase postinfarction rats. Starting immediately coronary ligation, male Wistar rats were treated with placebo or eplerenone (100 mg/kg/d). After 7 days, hemodynamic assessment was performed and endothelial function determined. Maximum acetylcholine-induced relaxation significantly attenuated aortic rings from heart failure MI,...
Summary Reperfusion injury may cause myocardial cell death and limit the benefit achieved by restoration of coronary artery patency in patients with acute infarction. The mechanism includes altered Ca2+ handling cytosolic mitochondrial overload, Ca2+- ATP-dependent hypercontraction, cytoskeletal fragility, permeability transition gap junction-mediated propagation death, as well alterations non-cardiomyocyte cells, particular platelets endothelial cells. cGMP modulates favorably all these...
Breast cancer is a heterogeneous disease, and its spread involves succession of clinical pathological stages. Screening predominantly based on mammography, which has critical limitations related to the effectiveness production false-positive or false-negative results, generating discomfort low adherence. In this context, infrared with attenuated total reflection Fourier transform (ATR FT-IR) spectroscopy emerges as non-destructive sample tool, non-invasive, label-free, operating-cost,...
It has been shown that sarcoplasmic reticulum calcium ATPase (SERCA) plays a critical role in reperfusion injury. Moreover, ischaemic post-conditioning (PoCo) results protein kinase G (PKG) activation which proposed to modulate phospholamban (PLB) and SERCA. We assessed whether PLB phosphorylation contributes the cardioprotective effects of PoCo. Isolated Sprague–Dawley rat hearts were submitted 40 min ischaemia with without PoCo protocol reduced infarct size by 48%. Reperfusion caused rapid...
Abstract Diminazene aceturate (DIZE) has been described as an angiotensin‐converting enzyme 2 (ACE2) activator. We aimed to investigate DIZE effects on blood pressure (BP) of spontaneously hypertensive rats (SHR) and Wistar Kyoto (WKY) rats. BP was recorded in awake unrestrained 24 hours after femoral artery catheterization. (15 mg/kg, s.c.) produced a fast decrease only SHR ( P < .01). Pre‐treatment with L‐NAME (10 iv) did not change the hypotensive effect systolic whereas mitigated...
Myocardial infarction (MI) was induced in rats by coronary ligation to compare changes vascular reactivity from animals that developed heart failure (InfHF) with those did not (Inf). Infarct size similar both groups. In vitro preparations of tail bed were used investigate the responses acetylcholine, sodium nitroprusside, and phenylephrine. Acetylcholine-induced relaxation impaired Inf group (53 ± 2%, <i>n</i> = 6) when compared Sham (80 6, <i>P</i> < 0.05). The maximal response...
This study was conducted to test the hypothesis that 17β-estradiol therapy improves redox balance by decreasing reactive oxygen species production and increasing nitric oxide (NO) bioavailability, favoring Akt pathway activation resulting in a better autonomic vascular control. Ovariectomized female Wistar rats were divided into 4 groups: (1) vehicle (VL) animals treated with pellet of for 21 days; (2) low dose (LE; 0.05 mg); (3) medium (ME; 0.2 (4) high (HE; 0.5 mg). Arterial pressure its...
The aim of this study was to evaluate the potential influence endogenous ovarian hormones on cardiac oxidative stress in renovascular hypertension. Female Wistar rats (N = 10 per group) were divided among 4 groups: (i) normotensive control; (ii) hypertensive (iii) ovariectomized; and (iv) ovariectomized rats. To induce hypertension, 2-kidney 1-clip (2K1C) Goldblatt’s method followed. Blood pressure (BP) enhanced (25%) 2K1C it not further altered animals. Lipid peroxidation (measured by...
Abstract Background Symptoms and signs of myocardial ischemia in the absence obstructive coronary disease are common hypertensive patients. This can be explained by CMD due to adverse remodeling arterioles which have also been reported SHR . Objective The aim this study was compare effects ramipril, perindopril, candesartan, atenolol, amlodipine, indapamide, HMR 1766 on Methods Eight groups 24‐wk‐old were treated for 8 wk. BP measured invasively at end treatment. After sacrifice, hearts...
Myocardial infarction (MI) induces a progressive ventricular remodelling leading to contractility depression. During the acute phase of MI inducible nitric oxide synthase (iNOS) expression and (NO) production increases in heart. The aim this study was investigate role iNOS left at 3 days after MI.Wistar rats were divided into: sham operated (SHAM, n = 23), (INF, 18); plus inhibitor, S-methylisothiourea (SMT) 5 mg kg(-1) day(-1), i.p. treatment (SHAM-SMT, 26) SMT (INF-SMT, 22)....
Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiomyopathy. The molecular mechanisms determining HCM phenotypes are incompletely understood. Myocardial biopsies were obtained from a group of patients with obstructive (n = 23) selected for surgical myectomy and 9 unused donor hearts (controls). A subset tissue-abundant samples 10) controls 6) was submitted to laser-capture microdissection isolate cardiomyocytes. We investigated relationship among clinical phenotype, cardiac...
This study aimed to verify vitamin D concentration in children and adolescents during the seasons of year compare between engaged outdoor activities those indoor activities.This is a cross-sectional with sample 708 (aged 6-18 years), excluding 109 (16 were over 19 years old; 39 had disease that required continuous treatment; 20 on medication; 34 no data), ending 599. The plasma 25-hydroxyvitamin D2 was measured commercial kits following manufacturer instructions.Participants who activities,...
The acute phase of myocardial infarction promotes an inflammatory response that stimulates inducible nitric oxide synthase (iNOS). We investigated the iNOS role on rat tail vascular bed reactivity 3 days after infarction. Vasodilator and vasoconstrictor responses were determined in isolated caudal beds from Wistar rats coronary artery ligation (CAL) sham-operated animals (SHAM). Rats treated with inhibitor S-methylisothiourea sulfate (SMT), 5 mg Kg day, i.p. or placebo. Concentration plasma...
Angola is a sub-Saharan African country where the population has scarce access to lipidlowering medication. We sought determine frequency of lipid disorders among Angolan nonusers lipid-lowering medication.A cross-sectional descriptive study was carried out in sample 604 workers from public sector. Blood pressure and anthropometric data were measured along with biochemical parameters including total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL-C) high-density (HDL-C)....
Oral mucositis is a painful condition that occurs in patients who undergo chemotherapy. Due to the worsening of oral mucositis, patient may progress worse clinical and interrupt antineoplastic treatment. There little literature on low-power laser therapy chemotherapy for other solid tumors. The purpose this study was investigate whether low-level (LLLT) applied before could prevent with tumors.Laser at frequency 630nm, dose 2J / cm2, prevention induced by specifically non-hematological...
Summary Non‐invasive assessment of central arterial pulse wave augmentation has been proved to be useful in predicting cardiovascular adverse events. Previous studies have shown that pre‐pubescent girls had greater pressure compared with height‐matched boys. This study sought investigate which factors contribute the body height‐independent sexual differences reflection observed childhood. cross‐sectional involved 819 children and adolescents (6‐18 years age) both sexes. Phenotypes...
The effects of exercise training on oxidative stress in gastrocnemius rats with pulmonary hypertension were studied. Four groups established: sedentary control (SC), monocrotaline (SM), trained (TC), (TM). Exercise was applied for 4 weeks, 5 days/week, 50-60 min/session, at 60% VO2 max. Right ventricular (RV) pressures measured, heart and removed morphometric/biochemical analysis. Lipid peroxidation (LPO), H2O2, GSH/GSSG, activity/expression antioxidant enzymes evaluated. Increased RV...