A5076390466- Synthesis and Biological Evaluation
- Chemical Synthesis and Reactions
- Nanomaterials for catalytic reactions
- Inorganic and Organometallic Chemistry
- Quinazolinone synthesis and applications
- Cystic Fibrosis Research Advances
- Carbohydrate Chemistry and Synthesis
- Synthesis and Biological Activity
- Enzyme Production and Characterization
- Synthesis and Characterization of Heterocyclic Compounds
- Neonatal Respiratory Health Research
- Phosphorus compounds and reactions
- Crystallization and Solubility Studies
- Enzyme Catalysis and Immobilization
- Advanced Glycation End Products research
- Organic Chemistry Cycloaddition Reactions
- Coenzyme Q10 studies and effects
- Organometallic Complex Synthesis and Catalysis
- Glycosylation and Glycoproteins Research
- Advanced battery technologies research
- Cancer therapeutics and mechanisms
- Inhalation and Respiratory Drug Delivery
- Legume Nitrogen Fixing Symbiosis
- Multicomponent Synthesis of Heterocycles
- Advanced biosensing and bioanalysis techniques
Italian Institute of Technology
2018-2020
Università di Camerino
2012-2016
Division of Chemistry
2015
University of North Carolina at Chapel Hill
2015
We identified a small molecule that, at picomolar concentrations, rescues mutant CFTR chloride channel from protein degradation.
The first CeCl<sub>3</sub>·7H<sub>2</sub>O–CuI catalyzed one-pot procedure for the synthesis of functionalized 2-substituted benzimidazoles as a valuable strategy in both industry and academia.
Abstract Amadoriases are a class of FAD-dependent enzymes that found in fungi, yeast and bacteria able to hydrolyze glycated amino acids, cleaving the sugar moiety from acidic portion. So far, engineered have mostly practical application measurement concentration albumin blood samples. However, these forms show relatively low absolute activity stability levels, which affect their conditions use. Therefore, enzyme stabilization is desirable prior function-altering molecular engineering. In...
Cystic fibrosis (CF) is a life-threatening autosomal recessive disease, caused by mutations in the CF transmembrane conductance regulator (CFTR) chloride channel. CFTR modulators have been reported to address basic defects associated with CF-causing mutations, partially restoring function terms of protein processing and/or channel gating. Small-molecule compounds, called potentiators, are known ameliorate gating defect. In this study, we describe identification...
The formation of a di-tert-alkyl nitroxide has been observed by Electron Spin Resonance during the exposure coenzyme CoQ(10), in both oxidized and reduced forms, to nitrogen dioxide (˙NO(2)) or nitric oxide (˙NO) presence oxygen. same kind also with CoQ(1), CoQ(3) 1-phenyl-3-methyl-2-butene, chosen as model compounds. In all cases, may be justified only admitting involvement isoprenic chain coenzymes particular addition ˙NO(2) double bond. A mechanism which accounts for well other compounds...
A Ce(III)/Cu(I)-catalytic system mediates the reaction of aryl- and alkylaldehydes (I) (IV) with o-phenylenediamine (II) to title compounds in good yields.