In a marine environment, specific proteins are secreted by mussels and used as bioglue to stick surface. These mussel present an unusual amino acid 3,4‐dihydroxyphenylalanine (known DOPA). The outstanding adhesive properties of these materials in the sea harsh conditions have been attributed presence catechol groups DOPA. Inspired structure composition proteins, dopamine‐modified hyaluronic (HA‐DN) prepared carbodiimide chemistry is form thin surface‐adherent dopamine films. This conjugate...

We suggest the use of biomimetic superhydrophobic patterned chips produced by a benchtop methodology as low-cost and waste-free platforms for production arrays cell spheroids/microtissues hanging drop methodology. Cell spheroids have wide range applications in biotechnology fields. For drug screening, they allow studying 3D models structures resembling real living tissues/tumors. In tissue engineering, are suggested building blocks bottom-up fabricated tissues. used wettability contrast to...

High-throughput fabrication of freestanding hydrogel particles with defined geometry and size for 3D cell culture, screenings, modular tissue engineering is reported. The method employs discontinuous dewetting using superhydrophobic-hydrophilic micropatterns.

We present a simple and economical method to produce potential open microfluidic polymeric device. Biomimetic superhydrophobic surfaces were prepared on polystyrene using phase separation methodology. Patterned two-dimensional channels imprinted the substrates by exposing surface plasma or UV–ozone radiation. The wettability of could be precisely controlled between superhydrophilic states changing exposure time. ability paths drive liquid flows in horizontal position was found significantly...

We propose a new low cost platform for high-throughput analysis that permits screening the biological performance of independent combinations biomaterials, cells and culture media. Patterned superhydrophobic flat substrates with controlled wettable spots are used to produce microarray chips accelerated multiplexing evaluation.

A novel hanging spherical drop system based on the use of biomimetic superhydrophobic flat substrates allows one to generate arrays independent spheroid bodies in a high throughput manner, order mimic<italic>in vivo</italic>tumour models lab-on-chip scale.

Medical adhesives and sealants often require that long-term adhesiveness is achieved. In this work, nanostructured coatings consisting of chitosan the adhesive bacterial exopolysaccharide levan are fabricated using layer-by-layer (LbL) assembly. Taking advantage electrostatic self-assembly mechanism LbL, charges both a phosphonate-derivatized (Ph-levan) measured feasibility constructing hybrid films monitored confirmed quartz crystal microbalance with dissipation monitoring (QCM-D). The...

The development of high‐throughput and combinatorial technologies is helping to speed up research that applicable in many areas chemistry, engineering, biology. A new model proposed for flat devices the screening accelerated evaluations multiplexed processes reactions taking place aqueous‐based environments. Superhydrophobic (SH) biomimetic surfaces based on so‐called lotus effect are produced, onto which arrays micro‐indentations allow fixing liquid droplets, rose‐petal effect. developed...

Bioinspired and adhesive multilayer membranes are produced using the layer-by-layer (LbL) assembly of chitosan (CHT), alginate (ALG) hyaluronic acid modified with dopamine (HA-DN). Freestanding without DN also as a control. The success synthesis HA-DN was confirmed UV-visible spectroscopy. Scanning electron microscopy images indicate that surface DN-containing is more porous than control ones; they present higher average thickness value for same number CHT/ALG/CHT/HA(-DN) tetralayers (n =...

Microarrays are a technological breakthrough for high-throughput screening of large numbers assays.

A high‐content screening method to characterize multifunctional multilayer films that combine mechanical adhesion and favorable biological response is reported. Distinct combinations of nanostructured are produced using layer‐by‐layer methodology their morphological, physicochemical, properties analyzed in a single microarray chip. Inspired by the composition adhesive proteins mussels, thin containing dopamine‐modified hyaluronic acid studied. Flat biomimetic superhydrophobic patterned chips...

The design and production of structures with nanometer‐sized polymer films based on layer‐by‐layer (LbL) are particular interest for tissue engineering since they allow the precise control physical biochemical cues implantable devices. In this work, a method is developed preparation nanostructured hollow multilayers tubes combining LbL template leaching. aim to produce polyelectrolyte multilayer tuned physical‐chemical properties study their effects cell behavior. final tubular characterized...

Lotus leaves are well known for their extremely water repellent surfaces. Marine mussels also a popular research topic when considering biological adhesives. Both organisms have inspired the development of several biomimetic materials. Herein we describe two-sided film made almost entirely from polystyrene onto which properties both lotus and mussel adhesive incorporated. On one side film, imparting micrometer nanometer scale hierarchical roughness yields superhydrophobicity repellency,...

The transformation of an oil shale sample from the Autun Basin in Massif Central, France, was studied using two different heating strategies: microwave irradiation and conventional heating. Microwave performed a single-mode cavity operating at frequency 2.45 GHz under inert atmosphere. Heating generated liquid products similar composition either or yields were cases, while overall energy requirements much lower irradiation. influence water vapor on decomposition also energy. In order to...

While developing tissue engineering strategies, inflammatory response caused by biomaterials is an unavoidable aspect to be taken into consideration, as it may early limiting step of regeneration approaches. We demonstrate the application flat and flexible films exhibiting patterned high-contrast wettability regions implantable platforms for high-content in vivo study biomaterials. Screening using high-throughput a powerful method detect hit spots with promising properties exclude...

The inside front cover shows an array of microdroplets on a superhydrophobic–superhydrophilic pattern. Fluorescence microscopy images hydrogel microparticles incorporating live cells expressing green fluorescent protein are visible in the background. These particles produced using effect discontinuous dewetting allowing for rapid pipetting-free fabrication thousands arrayed and with complex geometries sizes, as reported by P. Levkin co-workers page 7613.